Micronucleus Test
Mostrando 25-36 de 90 artigos, teses e dissertações.
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25. Genotoxicity of Nicotiana tabacum leaves on Helix aspersa
Tobacco farmers are routinely exposed to complex mixtures of inorganic and organic chemicals present in tobacco leaves. In this study, we examined the genotoxicity of tobacco leaves in the snail Helix aspersa as a measure of the risk to human health. DNA damage was evaluated using the micronucleus test and the Comet assay and the concentration of cytochrome
Genet. Mol. Biol.. Publicado em: 17/05/2013
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26. Evaluation of (anti)genotoxic activities of Phyllanthus niruri L. in rat bone marrow using the micronucleus test
Phyllanthus niruri L. (Euphorbiaceae), conhecida como "quebra-pedra", é uma planta medicinal utilizada frequentemente pela população no tratamento de problemas renais. Foram avaliadas as atividades genotóxicas, antigenotóxicas e citotóxicas de um extrato padronizado dessa espécie em ratos. Três grupos de doze animais foram tratados durante trinta dia
Braz. J. Pharm. Sci.. Publicado em: 2013-03
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27. Assessment of mutagenic, antimutagenic and genotoxicity effects of Mimosa tenuiflora
Genotoxic effects of Mimosa tenuiflora (Willd.) Poir, Fabaceae, were investigated by using both micronucleus test and bacterial reverse mutation assay in Salmonella typhimurium TA97, TA98, TA100, TA102 respectively. In respect of Ames test results show that the extract does not induce mutations in any strains of Salmonella typhimurium tested since the mutage
Rev. bras. farmacogn.. Publicado em: 01/02/2013
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28. Assessment of methyl methacrylate genotoxicity by the micronucleus test
The aim of this study was to evaluate the genotoxic potential of methyl methacrylate (MMA) vapor by simulating standard occupational exposure of 8 hours per day and using the micronucleus test. We used 32 adult male Wistar rats divided into three groups: A - 16 rats exposed to MMA for 8 hours a day, B - Eight rats receiving single subcutaneous doses of cyclo
Braz. oral res.. Publicado em: 2013-02
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29. Avaliação do potencial genotóxico do 51Cr2O3, marcador de digestibilidade, por meio da frequência de anormalidades nucleares em tilápias do Nilo (Oreochromis niloticus L.) / The evaluation of genotoxic potential of 51Cr2O3, a digestibility marker, by the frequency of nuclear abnormalities in Nile tilapia (Oreochromis niloticus L.)
Tilapia is the common name of a large number of species of cichlid fish. In aquaculture, this is one of the most profitable fish, since it presents lower feed conversion than other fish. The chromium oxide has been used as a marker for digestibility because it is inert and not alter the biological process of dietary intake. The use of radioactive form of chr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/09/2012
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30. Frequência de micronúcleos em células esfoliadas da mucosa bucal de pacientes obesos / Micronuclei frequency in exfoliated buccal cells of obese patients
A crescente incidência da obesidade e suas comorbidades constituem-se em um grande desafio para a saúde no mundo. Além da doença cardiovascular e do diabetes, dados epidemiológicos demonstraram ligação entre a obesidade e diversos tipos de câncer. As alterações citogenéticas tem sido utilizadas como biomarcadores para identificação de danos celu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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31. Avaliação morfofisiológica, fitoquímica e mutagênica de Passiflora edulis Sims f. flavicarpa Deg exposta a diferentes concentrações de alumínio
The influence of aluminum (Al) in two cultivars of Passiflora edulis is presented in two chapters: first a discussion on the experiment with the cultivar (cv.) FB 100 and second with the cultivar (cv.) FB 200. The study with cv. FB100 in greenhouse aimed to verify morphophysiological changes after 15 days of treatment with Al. For cv. FB 200 plants was evalu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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32. Genotoxicity assessment of Copaiba oil and its fractions in Swiss mice
Copaiba oil-resin, extracted from the trunk of Copaifera, and traditionally used in folk medicine in the treatment of various disorders, has been shown to be an effective antiinflamatory, antitumor, antitetanus, antiseptic and antiblenorrhagea agent. As, there are few studies evaluating its genotoxicity, this aspect of the commercial oil-resin, and its volat
Genetics and Molecular Biology. Publicado em: 02/08/2012
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33. Influência da variabilidade genética sobre biomarcadores de dano oxidativo e não oxidativo em pacientes com doença pulmonar obstrutiva crônica (DPOC)
Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive condition of poor reversibility that is characterized by airflow limitation associated with an abnormal inflammatory response of the lungs. Its development and progression are related to increased oxidative stress, which is an important pathogenic component of airway inflammation in this di
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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34. Relação do hábito alimentar e polimorfismos da MTHFR C677T com a instabilidade genômica em fumicultores gaúchos
Genetic damage can occur spontaneously under normal metabolic circumstances and can also be present in situations of dietary deficiency or inadequate intake of nutrients and excessive exposure to environmental mutagens. The purpose of this study was to evaluate the influence of the intake of micronutrients B12, B6 and folate and of polymorphism MTHFR C677T i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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35. Analysis of antimicrobial, cytotoxic and mutagenic potencial of extracts and substances obteined of diferente species of Piper / Análise do potencial antimicrobiano, citotóxico e mutagênico de extratos e substâncias obtidas de diferentes espécies de Piper
The infectious diseases are now one of the major causes of death in all over the world. The appearance of emerging infectious diseases and the problem of microbial resistance has driven the research for new antimicrobial agents. A thousand of years the medicinal plants has been used by your properties of healing. From this utilization scientific studies has
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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36. Mutagênese ambiental: estabelecimento de valores de referência para manguezais da Baía de Ilha Grande / Environmental mutagenesis: establishment of reference valves for mangroves of Ilha Grande Bay
Environmental studies have shown that substances generated by anthropogenic processes can cause adverse effects by interfering with the ecosystem natural balance. Mangroves perform essential functions in biological cycles and are Permanent Protection Area in Brazil. Unfortunately, they are being degraded above its support limit, leading to a reduction of the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011