Assessment of mutagenic, antimutagenic and genotoxicity effects of Mimosa tenuiflora

AUTOR(ES)

Silva, Viviane A., Gonçalves, Gregório F., Pereira, Maria S. V., Gomes, Isis F., Freitas, Andréa F. R., Diniz, Margareth F. F. M., Pessôa, Hilzeth L. F.

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

01/02/2013

RESUMO

Genotoxic effects of Mimosa tenuiflora (Willd.) Poir, Fabaceae, were investigated by using both micronucleus test and bacterial reverse mutation assay in Salmonella typhimurium TA97, TA98, TA100, TA102 respectively. In respect of Ames test results show that the extract does not induce mutations in any strains of Salmonella typhimurium tested since the mutagenicity index is less than 2. In the antimutagenic effect was observed that the extract at the concentrations tested significantly decreased the mutagenicity index of all strains tested which characterized the extract as antimutagenic in these conditions. In the micronucleus test in vivo, we observed that the concentrations used did not induce an increase in the frequency of micronucleus in normochromatic erythrocytes of mice. Therefore, we concluded that the extract of M. tenuiflora is not mutagenic in the absence of exogenous metabolizing system and does not induce an increase in the frequency of the micronucleus characterized as an agent not mutagenic in these conditions. Further studies of toxicity need to be made to the use of this plant in the treatment of diseases to be stimulated.

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