Citotoxic
Mostrando 13-24 de 43 artigos, teses e dissertações.
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13. Avaliação das linhagens Vero e MDCK na sinalização celular e como alternativas para estudo da nefrotoxicidade utilizando Anfotericina B
Due to intense pressure from society and scientific communities to reduce, refine and replace (3R´s) the use of animals in toxicity tests, alternative methods (in vitro) have been developed and recognized by various institutions worldwide. Cell lines are now widely available in cell banks and cellular cultivating techniques have become the most used in vitr
Publicado em: 2008
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14. Purificação e caracterização de uma toxina enterotóxica, citotóxina e letal produzida por amostras de Plesiomonas shigelloides isoladas de água de rio. / Purification and caracterization of an enterotoxic, cytotoxic and lethal toxin produced by Plesiomonas shigelloides isolated from river water.
Plesiomonas shigelloides is a ubiquous microorganism recognized as putative human and animal enteropathogen. Production of toxins has been related to their role in pathogenicity. At previous studies we detected a cytotoxin, named LCF (Lethal Citotoxic Factor) active on a variety of cells, causing intensive intracellular vacuolation and nuclear condensation,
Publicado em: 2008
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15. Chemical characterization and antioxidant and citotoxic activities from alecrim propolis / Análise química e atividades antioxidante e citotóxica de amostras de própolis de alecrim
Propolis is a complex mixture of substances derived from bee products and plant resins. Propolis color and texture vary widely and chemical composition is dependent on the hive locality. Bees use propolis to seal openings in the hive and to line it internally, which help keeping the environment aseptic. Propolis properties in medicine has been known since an
Publicado em: 2008
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16. Contribuição ao Conhecimento Químico de Esponjas do Litoral Cearense: Monanchora arbuscula / Contribution to Knowledge of Chemical Sponges Coastal Ceará: Monanchora arbuscula
Monanchora arbuscula (DUCHASSAING &MICHELOTTI, 1864) (Crambeidae) is an incrustant sponge, massive or branched with 15 cm high. Its color ranges from salmon to bright red or light pink with white conspicuous channels. Previous studies of M. arbuscula led to the isolation of some polycyclic guanidine alkaloids; ptilocaulin, 8bhydroxyptilocaulin, dehydrobatzel
Publicado em: 2008
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17. Estudo microbiológico fecal de linhagens de camundongos, de estirpes de E. coli e do meio ambiente em biotérios / Fecal microbiologic study of mice lineages, E. coli strains and the environment in laboratory animal facilities
Mice have been largely used at experiences since 17o century, so their microbiological quality should be investigated and kept safety in order to avoid they become ill or die during an investigation and dont transmit zoonosis to those who handle them; this is important in order to make the results presented in the experience be reliable. The Escherichia coli
Publicado em: 2008
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18. Synthesis and biological evaluation of thiazolidinic derivatives targeting new Antimicrobials / SÃntese e avaliaÃÃo biolÃgica de derivados TiazolidÃnicos visando novos Antimicrobianos
As doenÃas infecciosas sÃo responsÃveis por nÃmero apreciÃvel de Ãbitos da populaÃÃo mundial. A resistÃncia de microrganismos a antibiÃticos existentes tem aumentado dramaticamente nos Ãltimos anos. Neoplasias tambÃm sÃo fonte de grande preocupaÃÃo, visto que o cÃncer permanece como a segunda causa de morte, depois das desordens do coraÃÃo,
Publicado em: 2008
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19. Avaliação in vivo e in vitro da citotoxicidade, genotoxicidade e dos efeitos protetores de extratos de plantas do cerrado brasileiro
The use of plants for healing purposes is becoming increasingly popular, as soon as they are believed to be beneficial and free of side effects. However, most of information available on several medicinal herbs does not have any scientific supporting data and their use as medicaments is based simply on traditional folk. Among the plants used by the humanity
Publicado em: 2008
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20. Avaliação pré-clínica de lipossomas pH-sensíveis de longa circulação contendo cisplatina
cis-Diamminedichloroplatinum (II) or cisplatin (CDDP) is one of the anticancer agents most widely used in the treatment of solid tumors. However, the effectiveness of its clinical use is hampered by the induction of severe side effects and its tendency to provoke chemoresistance. To circumvent these inconveniences, drug delivery systems, such as long-circula
Publicado em: 2008
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21. Mecanismo de defesa e recuperação da fotossintese em Centrolobium tomentosum sob condições de estresse induzido por SO2 / Mechanism of defense and recovery of photosynthesis in Centrolobium tomentosum under conditions of stress induced by SO2
Large quantities of gaseous pollutants emited by urban-industrial areas emit contribute to the degradation of ecosystems with subsequent declines in vegetation. The photosynthesis is one of the first processes altered by the action of these pollutants and sulphur dioxide (SO2), as one of the most common and harmful air pollutants, drastically affect the phot
Publicado em: 2008
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22. Indigofera suffruticosa Mill: Um meio TerapÃutico Alternativo Anti-CÃncer
Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. To explore the potential of this plant and show a scientific basis to its utilization, this experimental work was developed investigating the presence of majority molecules in aqueous extr
Publicado em: 2007
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23. Avaliação de rotas metabólicas como mecanismo de ação da atividade tripanocida de Lignano-Lactonas / Evaluation of metabolic route as trypanocidal action mechanism of Lignan-Lactones
Neste trabalho o metilpluviatolido (1), o matairesinol (7), a hinoquinina (11), a cubebina (17) e seus respectivos derivados, providos de algumas modificações estruturais foram submetidos a testes in vitro para a determinação da atividade citotoxica e tripanocida. As substâncias não apresentaram atividade citotoxica significativa para a linhagem celula
Publicado em: 2007
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24. Análise da atividade linfoproliferativa de células esplênicas murinas frente a extrato de seis plantas medicinais da flora catarinense / Analysis of the citotoxic and lymphoproliferative activity of methanolic exctracts of medicinal plants on murine spleen cells
Some compounds have been used as immunomodulatory agents, enabling the function of the immune system to be modified, stimulating or suppressing it. There has been increasing interest in the study of therapeutic activities of plant extracts in recent years, including their immunomodulatory activity. The aim of the present work is to identify and evaluate the
Publicado em: 2007