Indigofera suffruticosa Mill: Um meio TerapÃutico Alternativo Anti-CÃncer
AUTOR(ES)
Jeymesson Raphael Cardoso Vieira
DATA DE PUBLICAÇÃO
2007
RESUMO
Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. To explore the potential of this plant and show a scientific basis to its utilization, this experimental work was developed investigating the presence of majority molecules in aqueous extracts of leaves of I. suffruticosa obtained by infusion and the cytotoxic and antitumoral effects of the extracts of I. suffruticosa leaves obtained by infusion and maceration. The material was obtained by a phytochemical screening of leaves where extractive protocols of identification of majority molecules present in the species. The majority identified molecules were: alkaloids, polyphenols, terpenes, sugars, and indigo. The aqueous extracts did not exhibit cytotoxicity against HEp-2 (Human Larynx Epidermoid Carcinoma Cells) cell lines by MTT method. The antitumor activity of aqueous extracts by infusion (64.53%) and maceration (62.62%) against Sarcoma 180 in mice at a dose of 50 mg/kg (i.p.), based on low order of toxicity was comparable to the control group, which showed a tumoral development of 100%. The extracts showed reaction effects in central and peripherical nervous systems and no alteration in muscle mass. Considering the low order of toxicity and the highly effective in inhibiting growth of solid tumor, the aqueous extracts of leaves of I. suffruticosa may be used as anti-cancer agent as an alternative therapeutic mean
ASSUNTO(S)
atividade antitumoral indigofera suffruticosa indigofera suffruticosa phytochemical assay extrato aquoso ensaio fitoquÃmico citotoxic activity antitumoral activity aqueous extract anatomia patologica e patologia clinica atividade citotÃxica
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