Citotoxic Activity
Mostrando 13-24 de 27 artigos, teses e dissertações.
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13. Synthesis and biological evaluation of thiazolidinic derivatives targeting new Antimicrobials / SÃntese e avaliaÃÃo biolÃgica de derivados TiazolidÃnicos visando novos Antimicrobianos
As doenÃas infecciosas sÃo responsÃveis por nÃmero apreciÃvel de Ãbitos da populaÃÃo mundial. A resistÃncia de microrganismos a antibiÃticos existentes tem aumentado dramaticamente nos Ãltimos anos. Neoplasias tambÃm sÃo fonte de grande preocupaÃÃo, visto que o cÃncer permanece como a segunda causa de morte, depois das desordens do coraÃÃo,
Publicado em: 2008
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14. Avaliação in vivo e in vitro da citotoxicidade, genotoxicidade e dos efeitos protetores de extratos de plantas do cerrado brasileiro
The use of plants for healing purposes is becoming increasingly popular, as soon as they are believed to be beneficial and free of side effects. However, most of information available on several medicinal herbs does not have any scientific supporting data and their use as medicaments is based simply on traditional folk. Among the plants used by the humanity
Publicado em: 2008
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15. Avaliação pré-clínica de lipossomas pH-sensíveis de longa circulação contendo cisplatina
cis-Diamminedichloroplatinum (II) or cisplatin (CDDP) is one of the anticancer agents most widely used in the treatment of solid tumors. However, the effectiveness of its clinical use is hampered by the induction of severe side effects and its tendency to provoke chemoresistance. To circumvent these inconveniences, drug delivery systems, such as long-circula
Publicado em: 2008
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16. Mecanismo de defesa e recuperação da fotossintese em Centrolobium tomentosum sob condições de estresse induzido por SO2 / Mechanism of defense and recovery of photosynthesis in Centrolobium tomentosum under conditions of stress induced by SO2
Large quantities of gaseous pollutants emited by urban-industrial areas emit contribute to the degradation of ecosystems with subsequent declines in vegetation. The photosynthesis is one of the first processes altered by the action of these pollutants and sulphur dioxide (SO2), as one of the most common and harmful air pollutants, drastically affect the phot
Publicado em: 2008
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17. Indigofera suffruticosa Mill: Um meio TerapÃutico Alternativo Anti-CÃncer
Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. To explore the potential of this plant and show a scientific basis to its utilization, this experimental work was developed investigating the presence of majority molecules in aqueous extr
Publicado em: 2007
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18. Análise da atividade linfoproliferativa de células esplênicas murinas frente a extrato de seis plantas medicinais da flora catarinense / Analysis of the citotoxic and lymphoproliferative activity of methanolic exctracts of medicinal plants on murine spleen cells
Some compounds have been used as immunomodulatory agents, enabling the function of the immune system to be modified, stimulating or suppressing it. There has been increasing interest in the study of therapeutic activities of plant extracts in recent years, including their immunomodulatory activity. The aim of the present work is to identify and evaluate the
Publicado em: 2007
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19. Estudos dos efeitos citotoxicos e de estresse oxidativo induzido pelo cloreto de cadmio associado ou não ao sulfato de zinco em celulas musculares esqueleticas e neoplasicas / Study of citotoxic effects and oxidative stress induced by cadmium chloride associated or not to zinc sulfate in skeletal muscle and neoplasic cells
The heavy metals as cadmium are a toxic agent since it is extensively utilized in industry and can be amply distributed in environment. The cadmium is research focused as its pathological consequences in human exposure as it has been classified as carcinogenic agent. This fact is evident since the cadmium inhalation can be related to lung tumour and many stu
Publicado em: 2006
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20. Comparative study of the aminopeptidases purified from liver of patients with normal and altered serum aminotransferases levels. / Estudo comparativo entre as aminopeptidases purificadas de fígado de pacientes com as aminotransferases séricas normais e alteradas.
Enzymes like aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are released by the liver during several pathologies and have been used in laboratory tests to evaluate hepatic damage. Aminopeptidases, enzymes that hydrolyze peptide bonds in N-terminal amino acids of proteins, are important in protein metabolism and might have altered activit
Publicado em: 2006
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21. Atividades antimicrobiana, citotÃxica, antitumoral e antiinflamatÃria de extratos brutos de Lippia alba (Mill.) N. E. Brown
Lippia alba (Mill.) N. E. Brown (Verbenaceae), amplamente distribuÃda em todo o territÃrio brasileiro, Ã conhecida popularmente como erva cidreira e utilizada na medicina popular como analgÃsica, febrÃfuga, antiinflamatÃria, antigripal e nas afecÃÃes hepÃticas. Plantas cultivadas na horta medicinal do LaboratÃrio de Fitoterapia da Empresa Pernambuc
Publicado em: 2006
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22. Chemical study and evaluation of cytotoxic activity from ascidians Didemnum psammatodes (Sluiter, 1895) and Eudistoma vannamei Millar, 1977 (Tunicata: Ascidiacea) / Estudo químico e avaliação da atividade citotóxica das ascídias Didemnum psammatodes(Sluiter, 1885) e Eudistoma vannameiMillar, 1977 (Tunicata: Ascidiacea)
Samples of Didemnum psammatodes were collected in Icapui (Ceara State) and Trairi (Ceara State). The methanolic extract from D. psammatodes, acquired from Icapui, was submitted to fractionation and purification through several chromatographic techniques and were obtained four nucleosides (2?-deoxyuridine, 2- deoxyinosine, thyimidine, and 2?-deoxyguanosine),
Publicado em: 2006
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23. Estudo fitoquÃmico e biolÃgico de Laguncularia racemosa (L.) Gaertn. f. (Mangue branco)
The family Combretaceae possesses species used in the popular medicine in the treatment of several diseases. The genius Laguncularia presents as only species the Laguncularia racemosa and it is typical of mangroves communities. The stem bark of Laguncularia racemosa, known popularly as white mangrove, they are used in the popular medicine to combat dysentery
Publicado em: 2003
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24. Terpenos de Wunderlichia crulsiana e Mikania sp. nov. / Terpenes from Wunderlichia crulsiana and Mikania sp. nov.
This work describes the chemical study of two plants which belong to the family Asteraceae: Mikania sp. nov. and Wunderlichia crulsiana. The dichlorometane extracts from leaves and stems of Mikania sp. nov. we studied and seven diterpenic acids were isolated and identified. The volatile oil from leaves and stems of this plant were also studied and twenty sub
Publicado em: 2000