Influencia do polimorfismo da haptoglobina na retinopatia diabetica em uma amostra da população brasileira / Haptoglobin polymorphism and diabetic retinoplasthy in a Brazilian population

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influence the development of retinopathy, an important microvascular complication in DM. In order to investigate this association in a Brazilian population, we determined the Hp genotypes of 317 diabetic patients with at least 10 years of disease. The patients were classified as DM-type 1 and DM-type 2, with and without diabetic retinopathy (DR). The Hp genotype frequencies of the different patient groups and of a control group consisting of 142 healthy individuals who had previously been studied were compared. No significant differences were observed for the three Hp genotypes. Hemoglobin A1c levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) and duration of diabetes, which are potential risk factors for DR, were also compared. Again no significant differences were observed for the three Hp genotypes. Thus, we conclude that this polymorphism is not associated with the presence of DR in the Brazilian population studied here

ASSUNTO(S)

haptoglobinas retinopatia diabetica diabetic retinopathy diabetes mellitus genetic polymorphism polimorfismo (genetica) haptoglobins

ACESSO AO ARTIGO

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