Haptoglobins
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Haptoglobin genotypes in sickle cell disease / Genotipos da haptoglobina nas doenças falciformes
Oxidative stress, particularly in the endothelium, exerts a strong influence on the genesis of sickle cell disease (SCD) vasoocclusion and, consequently, on patients clinical evolution and survival. The pathophysiology of SCD is centered on the polymerization property of the desoxy-hemoglobin (Hb) S, but genetic factors can act as modulators of its clinical
Publicado em: 2009
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2. Influencia do polimorfismo da haptoglobina na retinopatia diabetica em uma amostra da população brasileira / Haptoglobin polymorphism and diabetic retinoplasthy in a Brazilian population
Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influen
Publicado em: 2007
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3. Influencia do polimorfismo da haptoglobina na retinopatia diabetica em uma amostra da população brasileira / Haptoglobin polymorphism and diabetic retinoplasthy in a Brazilian population
A haptoglobina (Hp) é uma proteína de fase aguda que possui propriedades antioxidantes e imunomodulatórias. Três principais genótipos/fenótipos (Hp1-1, Hp2-1, Hp2-2) demonstram eficiências distintas em suas atividades e estão associados com a suscetibilidade e evolução de várias doenças, inclusive o diabetes mellitus (DM). Alguns estudos sugerem
Publicado em: 2007
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4. The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxa
Memórias do Instituto Oswaldo Cruz. Publicado em: 2003-06
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5. Immunogenetics of human haptoglobins: I. The antigenic structure of normal Hp phenotypes
The various antigenic determinants of serum haptoglobins (Hp) may be studied semiquantitatively in a radioimmunoassay system. Using three antisera of overlapping specificities, we constructed an antigenic model of the various Hp phenotypes comprising four distinct determinants. This adds a new determinant, situated near the hemoglobin binding site, to the th
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6. A SIMPLE METHOD FOR THE DETERMINATION OF SERUM HAPTOGLOBINS
Changes in the serum haptoglobin level have been reported in certain forms of anaemia (Allison and ap Rees, 1957; Allison, 1958; Nosslin and Nyman, 1958; Nyman, Gydell, and Nosslin, 1959), in hepatobiliary disease (Owen, Mackay, and Got, 1959) and in various inflammatory and chronic diseases (Jayle and Boussier, 1955; Allison and Blumberg, 1958). A simple co
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7. Genetic Control of Three Haptoglobins in Pigs
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8. Quantitative Variations of Haptoglobins in a Caucasian Family
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9. SERUM HAPTOGLOBINS IN HAEMOLYTIC STATES
Serum haptoglobin levels have been studied in patients with a number of haemolytic disorders.
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10. Chronic haemolysis after Lillehei-Kaster valve replacement. Comparison with the findings after Björk-shiley and Starr-Edwards mitral valve replacement.
Nineteen female and sixteen male patients who have had their heart valves replaced with Lillehei-Kaster valves were investigated for haemolysis four to 18 months after operation. Investigation included serum lactic dehydrogenase, serum haptoglobins, and urine haemosiderin. Red cells survival, using autologous red cells labelled with 51Cr, was measured in 12
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11. Haptoglobins in chronic lymphatic leukaemia
Haptoglobin phenotypes have been determined in 30 chronic lymphatic leukaemia patients and concentrations determined in 21 of these. The number of Hp1 phenotypes is slightly raised but not significantly so compared with a control population and is the same as that in first-degree relatives. Haptoglobin concentrations show higher concentrations in Hp1 than Hp
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12. Immunogenetics of human haptoglobins: II. Hp Bellevue, a cross-reacting mutant
Using a radioimmunoassay method in conjunction with double diffusion studies, we characterized the antigenic determinants of the three Hp Bellevue phenotypes. An antigenic model based on these data indicates that each phenotype comprises a heterogeneous group of proteins with properties depending on their content of normal (hpβ) and of mutant (hpβ-Bellevue