Desenvolvimento e caracterizaÃÃo de gel de biopolÃmero produzido pela fermentaÃÃo de melaÃo da cana-de-aÃÃcar pelo microorganismo Zoogloea sp. Contendo Ãcido Ãsnico

AUTOR(ES)

Mozart de AraÃjo NÃris

DATA DE PUBLICAÇÃO

2007

RESUMO

An exopolysaccharide produced by Zoogloea sp. from sugar cane molasses as a fibrous membrane was used to prepare a gel containing usnic acid, which presents antimicrobial activity. A method of drug extraction from the biopolymer gel was validated. The usnic acid, pure and drug-loaded biopolymer gel were characterized through differential scanning calorimetry (DSC) and thermogravimetric analyses (TGA). The content of usnic acid in the biopolymer gel was 100.7 %. DSC scans of dried films of pure and drug-loaded biopolymer showed comparable thermal patterns. In contrast, TGA curves shows that the presence of usnic acid improves the thermal stability of the biopolymer. In fact, a weight loss of 86.1 % was found for the biopolymer, whereas for the biopolymer containing usnic acid a weight loss of 69.6 % was achieved. Therefore the incorporation of usnic acid in a biopolymer gel offers a new economic feasible and biocompatible system for drug delivery

ASSUNTO(S)

farmacia gel Ãcido Ãsnico biopolÃmero anÃlises termicas zoogloea sp. gel biopolymer polysaccharides zoogloea sp. polissacarÃdeos usnic acid thermal analysis

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