Usnic Acid
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Interaction study between vancomycin and liposomes containing natural compounds against methicillin-resistant Staphylococcus aureus clinical isolates
ABSTRACT The treatment of infections caused by resistant microorganisms is limited, and vancomycin (VAN) treatment failures for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia are not uncommon, even when MRSA clinical isolates are susceptible to VAN. Thus, this study proposed the association of VAN with usnic acid and β-lapachone encapsulated
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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2. Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats
ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= 6) that received 25 mg/kg of encapsulated usnic acid by
An. Acad. Bras. Ciênc.. Publicado em: 2017-06
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3. Larvicidal activity of Ramalina usnea lichen against Aedes aegypti
ABSTRACT The larvicidal activity of the methanol extract, fractions and compounds 2-hydroxy-4-methoxy-6-propyl-methyl benzoate and (+)-usnic acid identified from the lichen Ramalina usnea (L.) R. Howe, Ramalinaceae, was tested against the third instar larvae of the Aedes aegypti mosquito. The methanol extract and three fractions showed activity, killing 100%
Rev. bras. farmacogn.. Publicado em: 2016-08
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4. Effects of the encapsulation of usnic acid into liposomes and interactions with antituberculous agents against multidrug-resistant tuberculosis clinical isolates
Mycobacterium tuberculosis (Mtb) has acquired resistance and consequently the antibiotic therapeutic options available against this microorganism are limited. In this scenario, the use of usnic acid (UA), a natural compound, encapsulated into liposomes is proposed as a new approach in multidrug-resistant tuberculosis (MDR-TB) therapy. Thus the aim of this st
Mem. Inst. Oswaldo Cruz. Publicado em: 29/04/2016
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5. Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation
The aim of this study was to develop a theoretical model using Anopheles gambiae GSTE2 structure as template for Aedes aegypti GSTE2 by homology modeling Docking simulations were performed for both the enzymes against usnic acid in neutral and anionic forms. Ramachandran plot revealed that 93.9% of the GSTE2 model residues were located on most favored region
Braz. arch. biol. technol.. Publicado em: 2014-10
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6. Biossíntese de vitamina E nos estágios intraeritrocitários de P. falciparum. / Vitamin E biosynthesis in intraerythrocytic stages of Plasmodium falciparum.
The study of isoprenoid biosynthesis in Plasmodium falciparum by 2C-methyl-D-erythritol-4-phosphate pathway (MEP) it is presented as a therapeutic target once that it is absent in humans. It was found in intraerythrocytic stages of P. falciparum the biosynthesis of isoprenoids by the MEP pathway. The shikimate and MEP pathways are the precursors of biosynthe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2011
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7. Chemical composition and antioxidant activity of lichen Toninia candida
In the present investigation, methanol, chloroform and petrol ether extracts from the lichen Toninia candida (Weber) Th. Fr, Catillariaceae, were assayed for their antioxidant activity. The phenolic composition of the extracts was determined by HPLC-UV analysis. The predominant phenolic compound in all the extracts was depsidone, norstictic acid. All the tes
Revista Brasileira de Farmacognosia. Publicado em: 07/10/2011
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8. Avaliação do potencial antileishmania dos compostos naturais isolados ácido úsnico, cumarin, quercetina e reserpina sobre as formas promastigotas e amastigotas de Leishmania Chagasi
As leishmanioses constituem-se por um complexo de doenças infectoparasitárias, causadas por parasitas do gênero Leishmania, e apresentam um espectro de sintomas variando de simples lesões cutâneas de cicatrização espontânea a lesões viscerais letais. A leishmaniose visceral, causada pela espécie Leishmania chagasi, no Brasil infecta cerca de duas m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/08/2008
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9. AvaliaÃÃo da toxidade oral do Ãcido Ãsnico microencapsulado
O objetivo do presente estudo à avaliar a toxicidade subcrÃnica oral do Ãcido Ãsnico encapsulado em microesferas de copolÃmero de Ãcido lÃctico e glicÃlico em comparaÃÃo com sua forma em suspensÃo. As microesferas contendo Ãcido Ãsnico foram preparadas utilizando a tÃcnica de emulsÃo (A/O/A) seguida de evaporaÃÃo do solvente e caracterizadas
Publicado em: 2008
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10. Desenvolvimento e caracterizaÃÃo de gel de biopolÃmero produzido pela fermentaÃÃo de melaÃo da cana-de-aÃÃcar pelo microorganismo Zoogloea sp. Contendo Ãcido Ãsnico
An exopolysaccharide produced by Zoogloea sp. from sugar cane molasses as a fibrous membrane was used to prepare a gel containing usnic acid, which presents antimicrobial activity. A method of drug extraction from the biopolymer gel was validated. The usnic acid, pure and drug-loaded biopolymer gel were characterized through differential scanning calorimetry
Publicado em: 2007
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11. AvaliaÃÃo da atividade antimicrobiana de sistema nanoparticulado contendo Ãcido Ãsnico
O presente trabalho avalia a caracterizaÃÃo fÃsico-quÃmica e a atividade antimicobacteriana in vitro do Ãcido Ãsnico (AU) encapsulado em nanocÃpsulas (NC-AU) de copolÃmero de Ãcido D,L-(lÃctico-glicÃlico) (PLGA) (50:50). O espectro de infravermelho da NC-AU mostrou uma banda de absorÃÃo em 1750 cm-1 atribuÃdo aos grupos Ãsteres do PLGA. As ban
Publicado em: 2007
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12. Estudo da relaÃÃo entre a atividade anti-tumoral in vitro do Ãcido Ãsnico e a ativaÃÃo da via metabÃlica p53
Usnic acid is a metabolite of lichen that exerts a wide variety of biological activities including cytotoxicity against cells derived from human malignant tumours. Although cytotoxicity of usnic acid has been extensively reviewed, its mechanism of action is still unclear. There are no data in the literature about the involvement of the tumour suppressor p53
Publicado em: 2006