AssociaÃÃo de polimorfismos nos genes MBL e β-defensina com a infecÃÃo pelo HPV eou HIV em regiÃo anal e perianal

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Papillomavirus human (HPV) is one of the most important involved ethiologics agents in the development of the cervical cancer. Two of the main involved factors of risk in the development of these malignant neoplasic are infection for the HPV and co-infection with sexually transmissible illnesses. The imunologic system is responsible for the recognition and elimination of strange substances. The protein binder of manose (MBL) is a protein synthecized in the liver, being one of the ways of activation of the system complement. Polymorphism inside of promotional the genic region of the MBL affects the amount of this protein inside of the serum, being associated with an important element in the appearance of some infectious illnesses. The gene hBD-1 is a candidate to a gene tumoral suppresor found modified in 90% of renal cancer and 82% of prostate cancer and polimorphism inside of the promotional region have been associates to the susceptibility to some infections capsize. Being thus, the present study it had as objective to verify the existence of correlation between polimorphism of the gene of the MBL-2 and the gene of à - defensin-1 with the susceptibility to the infections for HPV, HIV and HPV/HIV through the methodology of the real time PCR. The gotten results had not demonstrated association of the polymorphisms of MBL-2 gene in the studied groups (positive HIV, positive HPV, positive HPV/HIV). In relation to the polymorphisms of region -44 of gene HBD-1, association with the susceptibility only to the infection for the HIV between the analyzed groups was analised.

ASSUNTO(S)

mbl mbl hpv ciencias biologicas hiv hiv hpv coinfecÃÃo hbd and co-infecction hbd

ACESSO AO ARTIGO

Documentos Relacionados