AssociaÃÃo do Polimorfismo - 174 G/C da regiÃo promotora do gene IL-6 com fatores de risco cardiovascular em idosas brasileiras

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Interleukin-6 (IL-6) is a pleiotropic cytokine implicated with age-related disturbances by studies worldwide. The aim of this report was to verify an association of the IL-6 -174 C/G promoter polymorphism with the cytokine released in the serum as well as with presence of selected features representative of cardiovascular risk in aged women from the Brazilian population. A sample of 193 non-disabled subjects was genotyped by direct sequencing of PCR products. Each subject was investigated for impaired glucose regulation, diabetes, hypertension and dyslipidaemia. Laboratory tests were performed to assist clinical examination and definition of cardiovascular risk. Interleukin-6 and C-reactive protein were quantified by high sensitivity assays. General linear regression models or t Student tests were used to compare continuous variables among genotypes, followed by adjustments for confounding variables. The chi-square test was used to compare categorical variables. The genotypes were consistent with Hardy-Weinberg equilibrium proportions. In a recessive model, mean waist-to-hip ratio, serum glycated hemoglobin and serum glucose were markedly lower in C homozigotes (p = 0.001, 0.028 and 0.047, respectively). In a dominant hypothesis, G homozygotes displayed a trend for higher levels of circulating IL-6 (p = 0.092). Non-parametric analysis revealed that unbalanced glucose homeostasis and hypertension were findings approximately twofold more frequent among G homozygous subjects (p = 0.042 and p = 0.043, respectively). All together, our results implicate the IL-6 -174 G-allele with a greater cardiovascular risk. To our knowledge, this is the first investigation on IL-6 promoter variants and age-related disturbances in the Brazilian elderly population.

ASSUNTO(S)

genÃtipo brazil cytokine genÃtica interleukin-6 imunosenescence doenÃa cardiovascular genotype polymorphism interleucina-6 imunossenescÃncia polimorfismo citocinas cardiovascular disease genetics elderly brasil saude coletiva

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