Toxic Metabolites
Mostrando 25-36 de 165 artigos, teses e dissertações.
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25. Ameliorative effect of exogenous nitric oxide on oxidative metabolism in NaCl treated chickpea plants
Accumulation of salts in irrigated soils is one of the primary factors limiting yield in South Asia. We investigated whether exogenous nitric oxide (NO) supplementation as sodium nitroprusside has any ameliorating effect against NaCl induced oxidative damage in chickpea leaves. NaCl treatment (250 mM) alone and in combination with two concentrations of SNP (
Brazilian Journal of Plant Physiology. Publicado em: 2010
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26. Polimorfismos em CYP2E1, GSTM1 e GSTT1 e hepatotoxicidade no tratamento da tuberculose
Patients under treatment for tuberculosis (TB) frequently suffer adverse drug reactions. The most severe, hepatotoxicity is often related to toxic metabolites produced during the main drug metabolism, isoniazid (INH). INH is metabolized by N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1) and glutathione S-transferase (GSTM1 and GSTT1) enzymes. Poly
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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27. Estudo biomonitorado para avaliação das atividades antiinflamatória e analgésica da folhas da espécie Protium spruceanum (Benth) Engler. (Burseraceae)
The aim of this work was to perform the bioactivity study of analgesic and antiinflammatory activities in vivo and antioxidant property in vitro of crude ethanolic extract (EEB) from Protium spruceanum leaves. Were used for phytochemical screening tests to detect the main classes of secondary metabolites presents in the EEB and chromatographic techniques for
Publicado em: 2010
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28. Avaliação histopatológica e bioquímica da ínjúria hepática experimental induzida pelo tratamento crônico de ratos com o D-Limoneno.
This study aimed to evaluate the hepatotoxic potential of d-limonene - a component of volatile oils extracted from citrus plants. The preclinical research was conducted in an animal model (rats) with emphasis on histopathological and immunopathological studies for determination of tissue lesions and understanding of their pathogenic mechanisms. Sixty-three W
Publicado em: 2010
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29. Evaluation of the Polycyclic Aromatic Hydrocarbons (PAHs) bioavailability in Santos Bay through the biliary metabolites / Avaliação da biodisponibilidade de hidrocarbonetos policíclicos aromáticos (PAHs) na Baía de Santos através de metabólitos biliares
Marine environments near urban areas, such as Santos Bay, are subjected to toxic contaminants input, as polycyclic aromatic hydrocarbons (PAHs). The PAHs bioavailability can be evaluated through biomarkers, such as biliary metabolites and 7-ethoxyresorufin-O-deethylase activity (EROD). The goal of the present study was to evaluate the PAH bioavailability in
Publicado em: 2009
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30. Avaliação comparativa de cascas e folhas de Ziziphus joazeiro Mart (RHAMNACEAE) em relação aos perfis fitoquimico e toxicológico e as atividades antioxidante e antimicrobiana / Comparative evaluation of barks and leaves Ziziphus joazeiro Mart. (Rhamnaceae) in relation to the profiles phytochemistry and toxicological and antioxidant and antimicrobial activities
The presence of free radicals have been correlated with a great number of illnesses, such as cancer, renais, hepáticas, pulmonary, intestinais, cerebral illnesses, to articulate and oftamológicas. The methodologies most common to determine the antirust activity in practical way, fast sensible e are the ones that involve a radical cromóforo, simulating the
Publicado em: 2009
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31. CHARACTERIZATION, TOXICITY AND PATHOGENICITY OF Fusarium spp. IN SOYBEAN GENOTYPES UNDER NO TILLAGE / CARACTERIZAÇÃO, TOXICIDADE E PATOGENICIDADE DE Fusarium spp. EM GENÓTIPOS DE SOJA EM SISTEMA PLANTIO DIRETO
The sudden death syndrome (SDS), caused by species of Fusarium, is a disease difficult to control and there are no management techniques and resistant cultivars that give long-term positive results. This study aimed to assess populations of Fusarium spp. and Trichoderma spp. associated to eight soybean genotypes, cultivated under no tillage; to determine if
Publicado em: 2009
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32. Identificação de genes associados a produção de ocratoxina A em Aspergillus westerdijkiae
Mycotoxins, secondary metabolites of fungi, are toxic compounds found in great variety of foods, and when ingested can be very hazardous to animal and human health. Among the diverse mycotoxins, special interest has been given to the ochratoxin A (OA), produced by some species of Aspergillus and Penicillium. This mycotoxin is frequently found mainly in food
Publicado em: 2009
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33. CEFALOSPORINAS E SURFACTANTE NÃO-IÔNICO EM EFLUENTE HOSPITALAR: DETERMINAÇÃO, DEGRADAÇÃO POR MEIO DE FOTÓLISE E ELETROCOAGULAÇÃO E IDENTIFICAÇÃO DE SUBPRODUTOS E METABÓLITOS / CEFALOSPORINS AND NON IONIC SURFACTANTS IN HOSPITAL WASTEWATER: DETERMINATION, DEGRADATION BY MEANS OF PHOTOLYSIS AND ELECTROCOAGULATION AND IDENTIFICATION OF BYPRODUCTS AND METABOLITES
The currently incorrect and excessive consumption of pharmaceuticals and surfactants, mainly domestic usage, has become a concern to the scientific community around the world, due to the environmental consequences with regard to the bacterial resistance (characteristic of antibiotics), and alteration of hormonal systems (provoked by the degradation products
Publicado em: 2009
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34. SubstÃncias OrgÃnicas para o Controle de NematÃides em Cafeeiros. / Organic Substances for Nematode Control in Coffee Plants.
Two projects were carried out in order to contribute to the development of new methods to control the nematode Meloidogyne exigua Goeldi, 1887, which is widespread through Brazilian coffee plantations. In the first one, the bacteria Acinetobacter jonhsonii and Staphylococcus aureus, previously isolated from tomato (Lycopersicon esculentum Mill.) and pepper (
Publicado em: 2008
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35. Estudo dos mecanismos de ação da hidroquinona e fenol sobre o recrutamento leucocitário em respostas inflamatórias / Study of mechanisms of action of hydroquinone and phenol on leukocyte recruitment in inflammatory response
Hydroquinone (HQ) is one of the metabolites of benzene responsible for the toxic effects of exposure to solvent, as well as being part of the diet, medicines, tobacco and polluting the environment. Considering the immunotoxicity of this substance, our laboratory has investigated the role of exposure to HQ by prolonged period of time on acute inflammatory res
Publicado em: 2008
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36. Study of the toxicity induced by the anti-inflammatory sulindac and its metabolites, sulindac sulfone and sulindac sulfide / Estudo da toxicidade induzida pelo antiinflamatório sulindaco e seus metabólitos sulfona e sulfeto
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) known to inhibit non-selectively ciclooxygenases (COX) 1 and 2. Sulindac is therapeutically used as anti-inflammatory and analgesic in the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylits. In addition to this property, a role in the prevention/
Publicado em: 2006