Receptors Cxcr4
Mostrando 1-12 de 167 artigos, teses e dissertações.
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1. Relationships Between Phenotype and Function of Blood CD4+ T-Cells and Ascending Thoracic Aortic Aneurysm: an Experimental Study
Abstract Introduction: Non-familial ascending thoracic aorta dilation and aneurysms (TAAs) are silent diseases in elderly patients. Histopathology revealed that functionally polarized infiltrating CD4+ T-cells play a key role in aortic wall weakening. Objective: To evaluate the possible associations between phenotype and cytokine production of circulating
Braz. J. Cardiovasc. Surg.. Publicado em: 2019-02
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2. Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Abstract INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. METHODS: The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-09
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3. High degree of concordance between flow cytometry and geno2pheno methods for HIV-1 tropism determination in proviral DNA
Use of CCR5 antagonists requires previous viral tropism determination. The available methods have high cost, are time-consuming, or require highly trained personnel, and sophisticated equipment. We compared a flow cytometry-based tropism assay with geno2pheno method to determine HIV-1 tropism in AIDS patients, in Bahia, Brazil. We tested peripheral blood mo
Braz J Infect Dis. Publicado em: 2015-04
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4. Evaluation of Toll-like, chemokine, and integrin receptors on monocytes and neutrophils from peripheral blood of septic patients and their correlation with clinical outcomes
Recognition of pathogens is performed by specific receptors in cells of the innate immune system, which may undergo modulation during the continuum of clinical manifestations of sepsis. Monocytes and neutrophils play a key role in host defense by sensing and destroying microorganisms. This study aimed to evaluate the expression of CD14 receptors on monocytes
Braz J Med Biol Res. Publicado em: 11/04/2014
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5. Chemokines and chemokine receptors expression in the lesions of patients with American cutaneous leishmaniasis
American cutaneous leishmaniasis (ACL) presents distinct active clinical forms with different grades of severity, known as localised (LCL), intermediate (ICL) and diffuse (DCL) cutaneous leishmaniasis. LCL and DCL are associated with a polarised T-helper (Th)1 and Th2 immune response, respectively, whereas ICL, or chronic cutaneous leishmaniasis, is associat
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-06
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6. Expressão e função de CXCR7 em sídromes mielodisplásicas e leucemias / Expression and function of CXCR7 in myelodysplastic syndromes and leukemias
A medula óssea é constituída por microambientes específicos denominados "nichos". O fator SDF-1 (Stromal derived factor-1) foi identificado como um importante fator quimioatrativo produzido por células estromais da medula óssea. Sua ação sobre seu receptor CXCR4 desempenha função primordial na migração, retenção e desenvolvimento dos progenitor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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7. Avaliação da expressão de receptores de reconhecimentos e sinalização celular de células do sangue periférico de pacientes séticos e sua relação com desfecho clínico / Evaluation of recognition and signaling receptors in the peripheral blood cells of septic patients and its correlation with clinical outcome
A sepse pode ser definida como a síndrome da resposta inflamatória sistêmica desencadeada por infecção comprovada ou suspeita, sendo a sepse grave e o choque séptico as manifestações mais graves. O reconhecimento destes patógenos é feito por receptores específicos presentes nas células do sistema imune inato, que podem sofrer modulação durante
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/05/2011
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8. Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients
Leprosy is caused by Mycobacterium leprae, which induces chronic granulomatous infection of the skin and peripheral nerves. The disease ranges from the tuberculoid to the lepromatous forms, depending on the cellular immune response of the host. Chemokines are thought to be involved in the immunopathogenesis of leprosy, but few studies have investigated the e
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12
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9. In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production. We have expanded such observations evaluating the profile and kinetics of cytokines (IFN-γ, IL-12p70, IL-10, IL-13), chemokines (CCL
Brazilian Journal of Infectious Diseases. Publicado em: 2010-10
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10. Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood
Lipopolysaccharide (LPS) activates neutrophils and monocytes, inducing a wide array of biological activities. LPS rough (R) and smooth (S) forms signal through Toll-like receptor 4 (TLR4), but differ in their requirement for CD14. Since the R-form LPS can interact with TLR4 independent of CD14 and the differential expression of CD14 on neutrophils and monocy
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-09
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11. Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistoso
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-07
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12. Resposta de neutrófilos e monócitos do sangue periférico ao LPS de bactérias lisas e rugosas / Neutrophils and monocytes response to LPS from smooth and rough bacteria
Objective: To compare the biological action of R form and S form LPS in human peripheral blood neutrophils and monocytes. Methods: Cell surface receptors modulation, ROS and NO production were evaluated on monocytes and neutrophils in whole blood, and NF-êB activation was evaluated in isolated neutrophils by flow cytometry after incubation with R and S-LPS.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2008