Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
AUTOR(ES)
Silveira-Lemos, Denise, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Souza-Soares, Adriano Luiz, Castro-Silva, Pollyanna, Costa-Silva, Matheus Fernandes, Guimarães, Pedro Henrique Gazzinelli, Ferraz, Helena Barbosa, Oliveira-Fraga, Lúcia Alves, Teixeira, Mauro Martins, Corrêa-Oliveira, Rodrigo
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2010-07
RESUMO
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.
Documentos Relacionados
- The role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions
- Cytokine profile associated with chronic and acute human schistosomiasis mansoni
- Acute schistosomiasis mansoni: revisited and reconsidered
- Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis
- Chemokines and chemokine receptors expression in the lesions of patients with American cutaneous leishmaniasis