Receptors Cxcr4
Mostrando 13-24 de 167 artigos, teses e dissertações.
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13. Análise de células CD4+CD25+FoxP3+ no timo de camundongos infectados pelo Trypanosoma cruzi. / Analysis of cells CD4 CD25 FoxP3 in the thymus of mice infected for the Trypanosoma cruzi.
Natural regulatory T cells arise in the thymus during the normal process of differentiation and participate in the control of auto and alloimmune responses. Specifically in parasite infections, these cells may have antagonist roles, in favor of the microorganism or the host. Previous studies from our Laboratory revealed that acute Trypanosoma cruzi (T. cruzi
Publicado em: 2008
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14. Análise da atividade imunomodulatória da interleucina 27 (IL-27) na replicação do HIV-1 em células primárias humanas in vitro. / The immunomodulatory properties of the interleukin IL-27 on the HIV-1 replication in primary human cells.
A IL-27, novo membro da família da IL-12/IL-6, é uma citocina heterdimérica, crítica para a regulação do sistema imune. A IL-27 é produzida por células apresentadoras de antígenos, em resposta a diferentes estímulos como patógenos, LPS e ligantes de receptores do tipo Toll. Recentemente, foi demonstrado que a IL-27 inibe a replicação do HIV-1 in
Publicado em: 2008
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15. Correlation of chemokine ligands and its receptors with lymph node metastasis in Head and Neck Squamous Cell Carcinoma / Proteínas ósseas envolvidas na calcificação vascular de ratos urêmicos, paratireoidectomizados, alimentados com dieta rica e pobre em fósforo associada à infusão fixa de paratormônio
Local invasion and lymph nodal spread impact in the outcome of Head and Neck squamous cell carcinoma (HNSCC) patients (pts). We determined CXCR1-5, CCR7 and CX3CR1 mRNA expression by means of RNAse protection assay in 98 HNSCC primary tumors and 91 adjacent mucosa and 26 metastatic lymph nodes, correlating this data with outcome. CXCL12 and CCL19/CCL21, liga
Publicado em: 2007
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16. Correlação dos ligantes de quimiocinas e de seus respectivos receptores em relação à invasão de linfonodos nos carcinomas epidermóides em cabeça e pescoço / Correlation of chemokine ligands and its receptors with lymph node metastasis in Head and Neck Squamous Cell Carcinoma
Tanto a invasão local como o comprometimento de linfonodos cervicais tem grande impacto na sobrevida de pacientes portadores de carcinomas epidermóides de cabeça e pescoço. Em nosso trabalho nós primeiramente determinamos a expressão dos receptores de quimiocinas de CXCR1 a CXCR5, além de CCR7 e CX3CR1 pelo método do ensaio de proteção à ribonucle
Publicado em: 2007
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17. "Avaliação da expressão dos receptores de interleucina-8, CXCR1 e CXCR2, e da atividade proliferativa em fibroblastos de quelóide e de pele normal" / Determination of the interleukin-8 receptors CXCR1 and CXCR2, and proliferative activity in keloids and normal skin fibroblasts
O quelóide é um tumor fibroso benigno que ocorre durante a cicatrização da pele em indivíduos geneticamente predispostos. A cicatrização é um processo biológico complexo e depende da interação de diferentes estruturas teciduais e de um grande número de tipos celulares residentes e infiltrativos, que produzem citocinas. A interleucina 8 (IL-8), ci
Publicado em: 2006
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18. Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population
Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemok
Brazilian Journal of Infectious Diseases. Publicado em: 2003-08
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19. Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.
The CC chemokine receptors CCR5, CCR2, and CCR3 and the CXC chemokine receptor CXCR4 have been implicated as CD4-associated cofactors in the entry of primary and cell line-adapted human immunodeficiency virus type 1 (HIV-1) strains. CXCR4 is also a receptor for T-cell-line-adapted, CD4-independent strains of HIV-2. With the exception of this latter example,
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20. Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding
CD4 and the chemokine receptors, CXCR4 and CCR5, serve as receptors for human immunodeficiency virus type 1 (HIV-1). Binding of the HIV-1 gp120 envelope glycoprotein to the chemokine receptors normally requires prior interaction with CD4. Mapping the determinants on gp120 for the low-affinity interaction with CXCR4 has been difficult due to the nonspecific b
American Society for Microbiology.
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21. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells
In addition to their role as regulators of leukocyte migration and activation, chemokines and their receptors also function in angiogenesis, growth regulation, and HIV-1 pathogenesis — effects that involve the action of chemokines on nonhematopoietic cells.To determine whether chemokine receptors are expressed in human colonic epithelium, HT-29 cells were
American Society for Clinical Investigation.
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22. Distinct Mechanisms of Agonist-induced Endocytosis for Human Chemokine Receptors CCR5 and CXCR4
Desensitization of the chemokine receptors, a large class of G protein–coupled receptors, is mediated in part by agonist-driven receptor endocytosis. However, the exact pathways have not been fully defined. Here we demonstrate that the rate of ligand-induced endocytosis of CCR5 in leukocytes and expression systems is significantly slower than that of C
The American Society for Cell Biology.
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23. Antigenically Distinct Conformations of CXCR4
The major human immunodeficiency virus type 1 (HIV-1) coreceptors are the chemokine receptors CCR5 and CXCR4. The patterns of expression of the major coreceptors and their use by HIV-1 strains largely explain viral tropism at the level of entry. However, while virus infection is dependent upon the presence of CD4 and an appropriate coreceptor, it can be infl
American Society for Microbiology.
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24. Feline Immunodeficiency Virus Xenoinfection: the Role of Chemokine Receptors and Envelope Diversity
The use of chemokine receptors as cell recognition signals is a property common to several lentiviruses, including feline, human, and simian immunodeficiency viruses. Previously, two feline immunodeficiency virus (FIV) isolates, V1CSF and Petaluma, were shown to use chemokine receptors in a strain-dependent manner to infect human peripheral blood mononuclear
American Society for Microbiology.