Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
AUTOR(ES)
Miranda, Matheus Barbosa de, Melo, Adriene Siqueira de, Almeida, Mariana Silva, Marinho, Silvia Martins, Oliveira Junior, Wilson, Gomes, Yara de Miranda
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
2017-09
RESUMO
Abstract INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets. METHODS: The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry. RESULTS: Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease. CONCLUSIONS: These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.
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