Protein Structure Prediction
Mostrando 25-36 de 281 artigos, teses e dissertações.
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25. Use of artificial neural networks with Monte Carlo simulation applied to the protein folding problem / Uso de redes neurais artificiais na simulação Monte Carlo aplicado ao problema de dobramento de proteínas
This work proposes a new strategy to optimize the Monte Carlo method (MC) applied to the protein folding problem. This strategy is based on the information obtained from Artificial Neural Networks (ANNs), trained to predict the protein secondary structure. The work presents, initially, background knowledge about proteins and their structure. Follows an intro
Publicado em: 2006
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26. Prediction of the amount of secondary structure of proteins using unassigned NMR spectra: a tool for target selection in structural proteomics
With the advent of structural genomics, the need for fast structural information about unknown proteins has increased. We describe a new methodology, based on 13C, 15N and ¹H chemical shift dispersion to predict the amount of secondary structure of unassigned proteins from their 15N- and/or 13C-edited heteronuclear single quantum coherence (HSQC) spectra. T
Genetics and Molecular Biology. Publicado em: 2006
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27. Evolutionary algorithms, to proteins structures prediction / Algoritmos evolutivos para predição de estruturas de proteínas
A Determinação da Estrutura tridimensional de Proteínas (DEP) a partir da sua seqüência de aminoácidos é importante para a engenharia de proteínas e o desenvolvimento de novos fármacos. Uma alternativa para este problema tem sido a aplicação de técnicas de computação evolutiva. As abordagens utilizando Algoritmos Evolutivos (AEs) tem obtido res
Publicado em: 2006
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28. Caracterização Molecular e Expressão Heteróloga de um cDNA Codificante para Tiorredoxina do fungo patogênico humano Paracoccidioides brasiliensis / Cloning expression and insulin reduction activity analysis of a thioredoxin homalogue of human pathologe Paracoccidioides brasiliensis
The temperature-dependent dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of Paracoccidioidomycosis (PCM), a human systemic mycosis highly prevalent in countries of Latin America. P. brasiliensis is subjected to different insults from human host, such as oxidative stress caused by reactive oxygen species produced by the host during th
Publicado em: 2006
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29. Rule extraction from artificial neural networks applied to the problem of protein secondary structure prediction / Extração de regras de redes neurais artificiais aplicadas ao problema da determinação da estrutura secundária de proteínas
Extração de Regras de Redes Neurais Artificiais Aplicadas ao Problema da Previsão da Estrutura Secundária de Proteínas apresenta o estudo feito sobre a extração de conhecimento de Redes Neurais na forma de regras difusas. Na aplicação desta técnica, foi utilizado o problema da classificação da estrutura secundária de proteínas, em alfa, beta e
Publicado em: 2004
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30. Estudo QSAR de inibidores da secreção gastrica e simulação molecular da inibição
O estudo QSAR de inibidores da secreção gástrica e simulação molecular da inibição consiste em quatro fases. Na fase um busca-se validação dos métodos de simulação de solvatação. Na fase dois, a elaboração de modelos de relações quantitativas entre estrutura química e atividade biológica (QSAR) para compostos moduladores da secreção gá
Publicado em: 2004
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31. BLOOM BLAST Object Oriented Management: uma solução integrada para gerenciamento dos resultados do BLAST por meio de um paradigma orientado a objetos
Considered a special subject since the beginning of the 80s, bioinformatics can be defined as a way that covers all aspects of acquisition, processing, storage, distribution, analysis and interpretation of biological information. All this happens in a narrow sinergy with the molecular biology fundamental paradigm, which postulates that the genetic informatio
Publicado em: 2003
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32. Filmes de Langmuir e vesículas multilamelares de fosfolipídios e suas interações com um peptídeo oriundo da proteína p24 do HIV-1 / Langmuir films and multilamellar vesicles of phospholipids and its interactions with peptide from p24 protein from HIV-1
The investigation of the interaction mechanisms between the viruses and the host cells brings relevant information for the identification of targets on the development of drugs to prevent the penetration and/or development of the viruses. Peptides designed from viral proteins have been developed and tested on its capacities of inhibiting the merging process
Publicado em: 2003
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33. Protein structure prediction and analysis using the Robetta server
The Robetta server (http://robetta.bakerlab.org) provides automated tools for protein structure prediction and analysis. For structure prediction, sequences submitted to the server are parsed into putative domains and structural models are generated using either comparative modeling or de novo structure prediction methods. If a confident match to a protein o
Oxford University Press.
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34. EVA: evaluation of protein structure prediction servers
EVA (http://cubic.bioc.columbia.edu/eva/) is a web server for evaluation of the accuracy of automated protein structure prediction methods. The evaluation is updated automatically each week, to cope with the large number of existing prediction servers and the constant changes in the prediction methods. EVA currently assesses servers for secondary structure p
Oxford University Press.
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35. Coupled prediction of protein secondary and tertiary structure
The strong coupling between secondary and tertiary structure formation in protein folding is neglected in most structure prediction methods. In this work we investigate the extent to which nonlocal interactions in predicted tertiary structures can be used to improve secondary structure prediction. The architecture of a neural network for secondary structure
National Academy of Sciences.
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36. PROSPECT-PSPP: an automatic computational pipeline for protein structure prediction
Knowledge of the detailed structure of a protein is crucial to our understanding of the biological functions of that protein. The gap between the number of solved protein structures and the number of protein sequences continues to widen rapidly in the post-genomics era due to long and expensive processes for solving structures experimentally. Computational p
Oxford University Press.