BLOOM BLAST Object Oriented Management: uma solução integrada para gerenciamento dos resultados do BLAST por meio de um paradigma orientado a objetos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

Considered a special subject since the beginning of the 80s, bioinformatics can be defined as a way that covers all aspects of acquisition, processing, storage, distribution, analysis and interpretation of biological information. All this happens in a narrow sinergy with the molecular biology fundamental paradigm, which postulates that the genetic information is stored in the DNA sequences. After the public initiative of Human Genome Project, started in 1990 and its dead-line to be completed in 2005, there has been a great deal of growth in the volume of the nucletide sequences and aminoacids available in databases. In order to be converted into an effective benefit in medicine, agronomy and many other areas, all this genetic information needs to be processed, compared and analysed, which are the new challenges of bioinformatics, mathematics and statistics: to integrate and to make these data available through tools that allow specialists to look into such information, even those who are not into computer and molecular biology. The purpouse of this research is to integrate the largest possible number of services of sequence analysis, condensing them in one aplication of interative graphic interface. Initially four services are to be considerate: pairwise alignment, multiple alignment, protein secondary structure prediction and phylogenetic tree derivation. Through this study, it is supposed to make the genomic analysis more accessible, efficient and simplified, allowing researchers to concentrate mainly on the results of the biological interpretation. As far as bioinformatics is concerned, the results obtained in this research leads to the conclusion that the developing application software has made possible for the Biofoco researchers: better management, organization and availability of the genomic information; and the use of this software as a datamining tool, helping the visualization and exploration of the information that travels in and out through the many integrated tools. Concerning informatics, some of its main achievements are: validation and use of object-oriented technologies, CORBA, UML and RUP in the development of a scientific purpouse tool; integration with external utilities and with the Annotation and Genoma Systems; and integral reuse of the architecture used in the Genoma System.

ASSUNTO(S)

fast pam dna rna árvore filogenética blast protein programação dinâmica phylogenetic tree projeto genoma rna sequence alignment methods estrutura secundária de proteína blosum proteína fast genome project comparação de seqüências métodos de alinhamento de seqüências sequence comparison ciencia da computacao biologia molecular computacional bioinformatics dynamic programming blast blosum computational molecular biology protein secondary structure pam dna bioinformática

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