Methacholine
Mostrando 1-12 de 263 artigos, teses e dissertações.
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1. Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes
Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Therefore, we investigated the association between vitamin D levels and asthma outcomes in a murine model of obese asthma. We also evaluated NLRP3 inflammas
Braz J Med Biol Res. Publicado em: 13/11/2017
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2. Accuracy of spirometry for detection of asthma: a cross-sectional study
ABSTRACT BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this study was to analyze the accuracy of spirometry for detecting asthma in the general population.
Sao Paulo Med. J.. Publicado em: 2017-10
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3. Pituitary Adenylate Cyclase Activating Peptide (1-38) and its analog (Acetyl-[Ala15, Ala20] PACAP 38-polyamide) reverse methacholine airway hyperresponsiveness in rats
O objetivo deste estudo foi investigar funcionalmente e estruturalmente efeito broncodilatador do peptídeo ativador da adenilato ciclase pituitária (PACAP1-38) e da acetil-[Ala15, Ala20]PACAP 38-poliamida, potente análogo do PACAP-38, nos ratos desafiados pelo metacolina (MeCh). Ratos Wistar machos foram aleatoriamente divididos em cinco grupos. Grupos 1
Braz. J. Pharm. Sci.. Publicado em: 2015-09
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4. Assessment of the mechanics of a tissue-engineered rat trachea in an image-processing environment
OBJECTIVES:Despite the recent success regarding the transplantation of tissue-engineered airways, the mechanical properties of these grafts are not well understood. Mechanical assessment of a tissue-engineered airway graft before implantation may be used in the future as a predictor of function. The aim of this preliminary work was to develop a noninvasive i
Clinics. Publicado em: 2014-07
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5. The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin
OBJECTIVE: Formaldehyde exposure during the menstrual cycle is known to affect the course of allergic lung inflammation. Because our previous data demonstrated that formaldehyde combined with an ovariectomy reduced allergic lung inflammation, we investigated the putative role of ovary removal and progesterone treatment when considering the effect of formald
Clinics. Publicado em: 2013-12
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6. Proposição de um modelo matemático para o estudo da alteração mecânica do músculo liso da traquéia de ratos Wistar exposto à solução de formaldeído e submetido a doses crescentes de um agente contrátil / Proposition of a mathematical model to study the mechanical change of the smooth muscle of the trachea of Wistar rats exposed to formaldehyde solution and subjected to increasing doses of a contractile agent
The viscoelastic properties of the mammalian lung is mainly determined by the mechanical properties, structure and regulation of the airways smooth muscle. The exposure to polluted air may deteriorate these properties with harmful consequences to individual health. Formaldehyde is an important indoor pollutant that permeate through the smooth muscle tissue f
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/07/2012
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7. The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs
OBJECTIVE: To examine the preventive effect of a hydro-ethanolic extract of Nigella sativa on the tracheal responsiveness and white blood cell count in the lung lavage fluid of sensitized guinea pigs. METHODS: Three groups of guinea pigs sensitized to intraperitoneally injected and inhaled ovalbumin were given drinking water alone (group S), drinking water c
Clinics. Publicado em: 2011
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8. Avaliação espirométrica e da hiper-responsividade brônquica de crianças e adolescentes com asma atópica persistente moderada submetidos a natação
OBJETIVO: Investigar os benefícios a médio prazo de um programa de natação em escolares e adolescentes com asma atópica persistente moderada (AAPM). MÉTODOS: Realizou-se um estudo randomizado e prospectivo com crianças e adolescentes (7-18 anos de idade) com AAPM no Hospital de Clínicas da Universidade Estadual de Campinas (UNICAMP), Campinas (SP). A
Jornal de Pediatria. Publicado em: 2010-10
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9. Capnografia volumétrica na avaliação de crianças e adolescentes com asma persistente / Volumetric capnography for the avaliation of children and adolescents with persistent asthma
Objective: To study changes in the variables of volumetric capnography in children and adolescents with persistent asthma compared with controls, and investigate their changes with the use of bronchodilators and in response to bronchial provocation test. Methods: Hundred-three asthmatics and 40 healthy volunteers (aged 6-15 years) were serially enrolled. Spi
Publicado em: 2010
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10. Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission
Our objective was to determine the effect of arachidonylethanolamide (anandamide, AEA) injected intracerebroventricularly (icv) into the lateral ventricle of the rat brain on submandibular gland (SMG) salivary secretion. Parasympathetic decentralization (PSD) produced by cutting the chorda tympani nerve strongly inhibited methacholine (MC)-induced salivary s
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-06
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11. Efeito do condicionamento físico aeróbico de moderada intensidade na inflamação pulmonar alérgica crônica e na hiperresponsividade brônquica à metacolina em cobaias sensibilizadas / Effects of aerobic physical training with moderate intensity on chronic airway inflammation and bronchial hyperresponsivity to a methacoline in sensitized guinea pig
O treinamento físico (TF) melhora a resposta imune de indivíduos saudáveis e traz benefícios para o paciente asmático, mas seu papel na resposta alérgica é desconhecido. Objetivo: Avaliar o papel do TF de moderada intensidade na inflamação pulmonar alérgica crônica. Métodos: 54 cobaias, divididas em 4 grupos: grupo controle (C) (não sensibilizad
Publicado em: 2009
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12. Structural studies of acetylcholine agonists by NMR spectroscopy and theoretical calculations / Estudos estruturais de agonistas de acetilcolina pela espectroscopia de RMN e calculos teoricos
This work describes the conformational analysis of muscarine agonists of acetylcholine (ACh+): carbachol, metacholine and pilocarpine. It was performed from the analysis of 3JHH coupling constants and from ab initio theoretical calculations. Their conformational behavior is discussed taking into account the most important dihedral angles. Both the results fr
Publicado em: 2008