Hydroxyurea
Mostrando 25-36 de 447 artigos, teses e dissertações.
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25. The burden and quality of life of caregivers of sickle cell anemia patients taking hydroxyurea versus those not taking hydroxyurea
OBJECTIVE: To assess the burden and quality of life of caregivers of patients with sickle cell anemia taking hydroxyurea versus those of patients not taking hydroxyurea. METHODS: A cross-sectional study was performed of caregivers of outpatients with sickle cell anemia in two public hospitals in Campo Grande, MS, from January through June 2010. The World Hea
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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26. The influence of hydroxyurea on oxidative stress in sickle cell anemia
OBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capa
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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27. Hematological differences between patients with different subtypes of sickle cell disease on hydroxyurea treatment
OBJECTIVE: Sickle cell anemia and the interaction S/Beta thalassemia differ in hematological values due to microcytosis and hypochromia caused by the thalassemic mutation. The clinical benefit of long-term hydroxyurea treatment is undeniable in sickle cell disease with monitoring of the biological action of the drug being by the complete blood count. The obj
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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28. Comment on "The influence of hydroxyurea on oxidative stress in sickle cell anemia"
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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29. Anemia falciforme: desafios e avanços na busca de novos fármacos
Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the
Química Nova. Publicado em: 2012
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30. Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012
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31. Identificação dos haplótipos do gene S e aspectos hematológicos em indivíduos com anemia falciforme em Campo Grande, MS / Identification of S gene haplotypes and hematological features in individuals with sickle-cell anemia in Campo Grande, MS, Brazil
A anemia falciforme é uma doença genética determinada pela homozigose da hemoglobina S (HbS). Essa doença é marcada por variabilidade clínica dependente de fatores hereditários e adquiridos. Três características têm importância na gravidade da evolução clínica: os níveis de hemoglobina fetal (HbF), a concomitância de talassemia alfa e os hapl
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/12/2011
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32. Caracterização do gene LmHUS1 e de sua participação no fenômeno de amplificação gênica em Leishmania spp. / LmHUS1 gene characterization and its participation in the gene amplification in Leishmania spp.
The protozoan parasite Leishmania presents a dynamic and plastic genome in which gene amplification and chromosome translocations are common phenomena. Such plasticity hints at the necessity of dependable genome maintenance pathways. Eukaryotic cells have evolved checkpoint control systems that recognize altered DNA structures and halt cell cycle progression
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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33. Novos híbridos derivados de hidroxiureia e talidomida induzem a produção de hemoglobina fetal e apresentam atividade anti-inflamatória / New hybrid derivates of hydroxyurea and thalidomide induce the production of fetal hemoglobin and have anti-inflammatory activity
A anemia falciforme (AF) é um distúrbio genético da hemoglobina causado por uma mutação de ponto no gene da beta-globina com consequente produção de hemoglobina S (HbS). A polimerização de HbS causa a deformação, enrijecimento e diminuição da flexibilidade das hemácias, resultando em uma série de eventos que levam a redução da sua vida médi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/09/2011
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34. Avaliação funcional dos eosinófilos na anemia falciforme e o efeito do tratamento com hidroxiureia / Altered functional properties of eosinophils in sickle cell anemia and effects of hydroxyurea therapy
Sickle cell anemia is the homozygous state for hemoglobin S. Inflammation plays an important role in the vaso-occlusive process of the disease, where leukocytes, proinflammatory cytokines and adhesion molecules are increased in the peripheral blood of patients with sickle cell anemia. Leukocytosis is associated with morbidity and mortality in these patients.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2011
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35. Duffy Genotype and Clinical Manifestations Severity in Sickle Cell Anemia / Genótipo Duffy e Gravidade das Manifestações Clínicas na Anemia Falciforme
INTRODUCTION: Sickle cell anemia (SCA) presents with large clinical variability and previous studies suggest that genetic polymorphisms may act as complications predictors. The Duffy antigen appears to play an important role in the removal of inflammatory chemokines from the circulation, suggesting that Duffy-Negative individuals have lower clearance of cyto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/03/2011
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36. Analysis of oxidative status and biochemical parameters in adult patients with sickle cell anemia treated with hydroxyurea, Ceará, Brazil
BACKGROUND: Sickle cell anemia is a hemoglobinopathy caused by a mutation that results in the production of an abnormal hemoglobin molecule, hemoglobin S (Hb S). This is responsible for profound physiological changes, such as the sickling of red blood cells. Several studies have shown that hydroxyurea protects against vaso-occlusive crises. OBJECTIVE: The ai
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06