Hydroxyurea
Mostrando 37-48 de 447 artigos, teses e dissertações.
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37. Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-02
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38. Patients with sickle cell disease taking hydroxyurea in the Hemocentro Regional de Montes Claros
BACKGROUND: The development of therapies for sickle cell disease has received special attention, particularly those that reduce the polymerization of hemoglobin S. Hydroxyurea is a commonly used medication because it has the ability to raise levels of fetal hemoglobin, decrease the frequency of vaso-occlusive episodes and thus improve the clinical course of
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011
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39. AvaliaÃÃo dos NÃveis SÃricos de MalonaldeÃdo (MDA), Ãxido NÃtrico (NO) e Lactato Desidrogenase LÃctica (LDH) na Anemia Falciforme e suas CorrelaÃÃes Com o uso de HidroxiurÃia / Evaluation of serum levels of malonaldehyde (MDA), nitric oxide (NO) and lactate dehydrogenase (LDH) in sickle cell disease and their correlation with the use of hydroxyurea.
A anemia falciforme (AF) se caracteriza por anemia hemolÃtica crÃnica e com fenÃmenos vaso-oclusivos, seguidos de lesÃes a ÃrgÃos alvos, responsÃveis pela mortalidade associada a esta doenÃa. O fenÃmeno vaso-oclusivo està associado ao processo inflamatÃrio desencadeado pela polimerizaÃÃo da HbS desoxigenada, favorecendo a impactaÃÃo das hemÃc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2009
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40. Role of nitric oxide and the cyclic guanosine monophosphate dependent patway on the adhesive properties leucocytes of sickle cell disease patients / Ação do oxido nitrico e da via dependente de guanosina monofosfato ciclico nas propriedades adesivas de leucocitos de pacientes com anemia falciforme
Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell disease (SCD). Since nitric oxide (NO) bioavailability is decreased in SCD and NO may inhibit leukocyte adhesion, we determined whether stimulation of NO-signalling pathways can decrease the adhesive properties of neutrophils from SCD individuals (SCDneu). SCDne
Publicado em: 2008
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41. SÃntese e AvaliaÃÃo das Atividades Anti-Toxoplasma gondii e Antimicrobiana de BenzaldeÃdo 4-Fenil-3-tiossemicarbazonas e Derivados 2[(Fenilmetileno)hidrazono]-3-fenil-4-tiazolidinona-5-substituÃdos
Parasitic diseases, as toxoplasmosis, affect millions of people, and they are responsible for some of the most important and prevalent diseases of humans and domestic animals. These diseases result in considerable morbidity and mortality worldwide, especially in developing countries. The toxoplasmosis is caused by an intracellular parasite, Toxoplasma gondii
Publicado em: 2007
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42. The effect of tyrosine-kinase inhibitors on the apoptosis machinery in chronic myeloid leukemia / Efeitos dos inibidores de tirosina-quinase sobre a maquinaria apoptótica na leucemia mielóide crônica
Chronic myeloid leukemia (CML) is a myeloproliferative disease resultant of a clonal expansion of pluripotent hematopoietic stem cells. The CML physiopathology is associated with a translocation between chromosomes 9 and 22 long arms, promoting the formation of a bcr-abl neogene, which codifies the Bcr-Abl protein. The Bcr-Abl oncoprotein presents tyrosine-k
Publicado em: 2007
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43. Acidification of the parasitophorous vacuole containing Toxoplasma gondii in the presence of hydroxyurea
Toxoplasma gondii se multiplica dentro do vacúolo parasitóforo que não é reconhecido pela defesa primária não oxidativa de células hospedeiras: a fusão com organelas ácidas. Estudos anteriores mostraram que hidroxiuréia interrompeu a multiplicação dos parasitos intracelulares causando sua eliminação. No presente trabalho nós investigamos o mec
Anais da Academia Brasileira de Ciências. Publicado em: 2006-09
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44. Effect of hydroxyurea and nitric oxide donors in the expression and function of adhesion molecules in red blood cells of sickle cell disease / Efeito da hidroxiureia e de doadores de oxido nitrico na expressão e função das moleculas de adesão em celulas vermelhas de pacientes com anemia falciforme
A anemia falciforme é um distúrbio genético da hemoglobina causado por uma mutação de ponto produzindo hemoglobina S (HbS) que quando desoxigenada causa, entre outros sintomas, eventos vaso-oclusivos. Um dos mecanismos indicados como causador da vaso-oclusão é a adesão de hemácias falciformes ao endotélio dos vasos. Eritrócitos falciformes e norma
Publicado em: 2006
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45. Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal / Characterization of cGMP-specific phosphodiesterases (PDE) in erythroid cells and effects PDE inhibitors on the production of fetal hemoglobin
Sickle cell disease (SCD) is a systemic disease with a multifaceted pathophysiology; the polymerisation of the sickle haemoglobin molecule (HbS), when deoxygenated, has many consequences that include haemolysis, inflammation, dysregulated nitric oxide (NO) homeostasis and oxidative abnormalities. Agents, such as hydroxyurea (HU), that increase levels of feta
Publicado em: 2006
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46. Mutagenicity of hydroxyurea in lymphocytes from patients with sickle cell disease
Hydroxyurea is commonly used in the treatment of myeloproliferative diseases and in patients with sickle cell disease (SCD). The use of this antineoplastic agent in patients with SCD is justified because of the drug's ability to increase fetal hemoglobin levels, thereby decreasing the severity of SCD. However, high doses or prolonged treatment with hydroxyur
Genetics and Molecular Biology. Publicado em: 2004
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47. Effect of hydroxyurea on G gamma chain fetal hemoglobin synthesis by sickle-cell disease patients
Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis and consequently decrease the severity of pain episodes. Fetal hemoglobin, which is formed by gamma-globin chains A and G, is present in a constant composition throughout fetal development: about 75% of Ggamma and 25% of Agamma. In contrast, adult red cells c
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-10
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48. Effect of hydroxyurea on the intracellular multiplication of Toxoplasma gondii, Leishmania amazonensis and Trypanosoma cruzi
Toxoplasma gondii, Leishmania amazonensis and Trypanosoma cruzi are obligate intracellular parasites that multiply until lysis of host cells. The present study was undertaken to evaluate the effect of hydroxyurea (an inhibitor of cell division at the G1/S phase) on the multiplication of L. amazonensis, T. gondii, and T. cruzi in infected host cells. Infected
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-01