Anemia falciforme: desafios e avanços na busca de novos fármacos
AUTOR(ES)
Santos, Jean Leandro dos, Chin, Chung Man
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG - GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid by a valine in the β chain of hemoglobin. Despite the huge progress on the molecular knowledge of the disease in recent years, few therapeutic resources were developed. Currently, the treatment is mainly done with the anticancer agent hydroxyurea. This review summarizes current knowledge about possible targets and new approaches to the discovery new compounds to treat the symptoms of SCD.
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