Hydroxyurea
Mostrando 13-24 de 447 artigos, teses e dissertações.
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13. Clinical, hematological and genetic data of a cohort of children with hemoglobin SD
ABSTRACT INTRODUCTION: The hemoglobin FSD is very uncommon in newborn screening programs for sickle cell disease. In the program of Minas Gerais, Brazil, the clinical course of children with hemoglobin SD was observed to be heterogeneous. The objective of this study was to estimate the incidence (1999-2012) and to describe the natural history of a cohort o
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-09
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14. Left ventricular hypertrophy in children, adolescents and young adults with sickle cell anemia
OBJECTIVE: The aims of this study were to estimate the frequency of left ventricular hypertrophy and to identify variables associated with this condition in under 25-year-old patients with sickle cell anemia.METHODS: A cross-sectional study was performed of children, adolescents and young adults with sickle cell anemia submitted to a transthoracic Doppler ec
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-10
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15. Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state
Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study. All patients were taking hydroxyurea for at least six months and were followed at the outpatient clinic of a hospital in Fortaleza, Ceará, Braz
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-06
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16. Socioeconomic and demographic characteristics of sickle cell disease patients from a low-income region of northeastern Brazil
Objective: To characterize the socioeconomic and demographic aspects of sickle cell disease patients from the state of Rio Grande do Norte (RN), Northeast Brazil, and their adherence to the recommended treatment. Methods: This cross-sectional descriptive study was performed at referral centers for the treatment of hematological diseases. One hundred and fi
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-06
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17. Standardization method for measurement of hydroxyurea by Ultra High Efficiency Liquid Chromatography in plasma of patients with sickle cell disease
A anemia falciforme (AF) é uma doença hereditária recessiva caracterizada por anemia hemolítica crônica, inflamação crônica e episódios agudos de hemólise. Hidroxiureia (HU) é amplamente utilizada para aumentar os níveis de hemoglobina fetal (Hb F). O objetivo consiste em padronizar e validar um método para a quantificação de HU no plasma huma
Braz. J. Pharm. Sci.. Publicado em: 2014-09
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18. Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia
Background: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-04
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19. Comment on "Influence of βS-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia"
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-04
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20. Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea
A hidroxiuréia (HU) constitui o avanço mais importante no tratamento da anemia falciforme (AF) por prevenir complicações e aumentar a qualidade de vida dos pacientes. Entretanto, alguns aspectos do tratamento com HU permanecem obscuros, incluindo a sua ação e potencial toxicidade em outras células sanguíneas, tais como neutrófilos. Este estudo utili
Braz. J. Pharm. Sci.. Publicado em: 2014-04
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21. Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease
BACKGROUND: Mastocytosis is a clonal disorder characterized by the accumulation of abnormal mast cells in the skin and/or in extracutaneous organs. OBJECTIVES: To present all cases of mastocytosis seen in the Porto Hospital Center and evaluate the performance of World Health Organization diagnostic criteria for systemic disease. METHODS: The cases o
An. Bras. Dermatol.. Publicado em: 2014-01
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22. Protective effect of flavonoids against reactive oxygen species production in sickle cell anemia patients treated with hydroxyurea
OBJECTIVE: The aim of this study was to evaluate the protective effects of quercetin, rutin, hesperidin and myricetin against reactive oxygen species production with the oxidizing action of tert-butylhydroperoxide in erythrocytes from normal subjects and sickle cell anemia carriers treated with hydroxyurea. METHODS: Detection of intracellular reactive oxygen
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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23. Evaluation of renal function in sickle cell disease patients in Brazil
The objective of this study was to investigate renal function in a cohort of 98 patients with sickle cell disease (SCD) followed up at a tertiary hospital in Brazil. Clinical and laboratory characteristics at the time of the most recent medical examination were analyzed. Renal function was evaluated by the estimation of glomerular filtration rate (GFR) by th
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-07
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24. Comment on "The burden and quality of life of caregivers of sickle cell anemia patients taking hydroxyurea versus those not taking hydroxyurea"
Rev. Bras. Hematol. Hemoter.. Publicado em: 2012