Dna Fragmentation
Mostrando 1-12 de 630 artigos, teses e dissertações.
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1. The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study
ABSTRACT Purpose: Sperm DNA fragmentation (SDF) and seminal oxidative stress are emerging measurable factors in male factor infertility, which interventions could potentially reduce. We evaluated (i) the impact of lifestyle changes combined with oral antioxidant intake on sperm DNA fragmentation index (DFI) and static oxidation-reduction potential (sORP), a
International braz j urol. Publicado em: 2022
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2. Oxidative origin of sperm DNA fragmentation in the adult varicocele
ABSTRACT Purpose: Sperm DNA fragmentation is a major cellular mechanism underlying varicocele-related male infertility. However, the type of DNA fragmentation - whether oxidative or of another nature - remains unknown. Thus, the aim of this study was to evaluate single- and double-stranded sperm DNA fragmentation, and oxidative-induced sperm DNA damage in m
Int. braz j urol.. Publicado em: 2021-03
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3. Diosmin induces caspase-dependent apoptosis in human glioblastoma cells
Abstract: Diosmin is a flavone glycoside clinically used as the main component of Daflon for the treatment of venous diseases. Several studies demonstrated that this natural compound can induce apoptosis in different tumors. However, isolated diosmin has not been studied regarding its effects on glioblastoma so far. Since glioblastoma is a highly lethal and
An. Acad. Bras. Ciênc.. Publicado em: 02/12/2019
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4. Assessment of heavy metals and its impact on DNA fragmentation in different fish species
Resumo Este estudo foi conduzido para avaliar a poluição da água examinando a fragmentação do DNA em órgãos de peixes selecionados (rim, fígado, brânquias e tecido muscular) de Wallago attu, Sperata sarwari, Vulgaris vulgaris e Labeo rohita coletados de uma conhecida área poluída do rio Chenab, Paquistão e de um local de controle. Os peixes foram
Braz. J. Biol.. Publicado em: 25/11/2019
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5. In situ DNA fragmentation during the re-establishment of desiccation tolerance in germinated seeds of Cedrela fissilis Vell.
Resumo: A desidratação é um procedimento necessário antes de expor as sementes ao armazenamento a longo prazo, mas isso está associado à lesão ligada ao metabolismo mediada por lesão celular. A fim de avaliar as alterações celulares durante o restabelecimento da tolerância à dessecação (TD) em sementes germinadas de C. fissilis e sua relação
J. Seed Sci.. Publicado em: 01/07/2019
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6. Efeito da adição de plasma seminal oriundo de animais de alta e baixa fertilidade na criopreservação de espermatozoides da cauda do epidídimo e do ejaculado de garanhões subférteis
RESUMO O objetivo do presente estudo foi avaliar o efeito da adição de plasma seminal de garanhões de alta e baixa fertilidade sobre a congelabilidade e a viabilidade de espermatozoides do ejaculado (EJ) e do epidídimo (EP) de garanhões subférteis. Foram utilizados seis garanhões com histórico de subfertilidade. Após coleta, espermatozoides do ejacu
Arq. Bras. Med. Vet. Zootec.. Publicado em: 14/06/2019
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7. Analysis of radioprotection and antimutagenic effects of Ilex paraguariensis infusion and its component rutin
DNA repair pathways, cell cycle checkpoints, and redox protection systems are essential factors for securing genomic stability. The aim of the present study was to analyze the effect of Ilex paraguariensis (Ip) infusion and one of its polyphenolic components rutin on cellular and molecular damage induced by ionizing radiation. Ip is a beverage drank by most
Braz J Med Biol Res. Publicado em: 16/07/2018
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8. Circulating cell-free DNA as a biomarker in the diagnosis and prognosis of colorectal cancer
Abstract Colorectal cancer (CRC) is a disease without evident clinical symptoms in early stages, leading to late diagnosis and disease management. Current diagnostic and prognostic tools require invasive procedures and circulating molecular biomarkers fail to have optimal sensitivity and specificity. Circulating biomarkers with high clinical performance may
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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9. Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes
ABSTRACT Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. The current study is aimed to investigate the possible prophylactic effect of star anise extracts (SAE) on the t
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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10. Mycobacterium tuberculosis promotes genomic instability in macrophages
BACKGROUND Mycobacterium tuberculosis is an intracellular pathogen, which may either block cellular defensive mechanisms and survive inside the host cell or induce cell death. Several studies are still exploring the mechanisms involved in these processes. OBJECTIVES To evaluate the genomic instability of M. tuberculosis-infected macrophages and compare it
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-03
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11. Phenolic Content and Biomolecule Oxidation Protective Activity of Globularia alypum Extracts
ABSTRACT The protective activity of methanolic (Met E) and aqueous (Aq E) extracts of Globularia alypum L. (G. alypum) against DNA, lipid and protein oxidative damage was investigated. Moreover, the scavenging, chelating, and reducing power activities of the extracts were also evaluated. Phytochemical analysis was performed to determine phenolic compounds. R
Braz. arch. biol. technol.. Publicado em: 17/08/2017
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12. Evaluation of cytotoxic activity of protein extracts from the leaves of Morinda pubescens on human cancer cell lines
ABSTRACT Biologically active proteins isolated from plant species can be used in traditional medicine as prolific resources for new drugs Morinda pubescens Sm., Rubiaceae, is a promising medicinal plant which is widely used in folk medicine to treat fever due to primary complex, ulcer and glandular swellings. In this study, proteins were extracted from the l
Rev. bras. farmacogn.. Publicado em: 2017-02