Diterpenes
Mostrando 13-24 de 116 artigos, teses e dissertações.
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13. SAPONIFICAÇÃO ASSISTIDA POR MICRO-ONDAS NA EXTRAÇÃO DE DITERPENOS EM CAFÉ ARÁBICA TORRADO
The extraction of kahweol and cafestol involves saponification reaction. This step is important for the efficiency of the extraction as the diterpenes are susceptible to structural changes during hydrolysis. The microwave-assisted saponification has been successfully used in different matrices, but there is no previous report of the use of this technique in
Quím. Nova. Publicado em: 2017-09
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14. STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF DITERPENES FOR TREATMENT OF ALZHEIMER'S DISEASE
Alzheimer's disease is an irreversible, degenerative and age-related disease which is growing more and more with the increase in life expectancy. Kaurane diterpenes are a class of natural products available in large amounts in nature and isolated from plants grown worldwide. In the present work¸ twenty-seven kaurane diterpenes of natural origin and some rea
Quím. Nova. Publicado em: 2017-09
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15. Anti-inflammatory action of ethanolic extract and clerodane diterpenes from Casearia sylvestris
ABSTRACT The present study aimed to investigate the anti-inflammatory activity of ethanolic extract from Casearia sylvestris Sw., Salicaceae, leaves and to identify the compounds responsible for this activity. The ethanolic extract from C. sylvestris leaves was fractionated by solid phase extraction and the chemical composition of extract and fractions were
Rev. bras. farmacogn.. Publicado em: 2017-08
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16. Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd
Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry
J. Braz. Chem. Soc.. Publicado em: 2017-06
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17. Cytotoxic activity of the chloroform extract and four diterpenes isolated from Salvia ballotiflora
Abstract New compounds with chemotherapeutic activity are sought after, and plants are an important source of these compounds. Four diterpenes, 19-deoxyicetexone, 7,20-dihydroanastomosine, icetexone and 19-deoxyisoicetexone, were isolated from the hexane-washed chloroform extract of Salvia ballotiflora. The cytotoxic activity of the hexane-washed chloroform
Rev. bras. farmacogn.. Publicado em: 2017-06
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18. Antitubercular Activity Increase in Labdane Diterpenes from Copaifera Oleoresin through Structural Modification
The labdane diterpenes copalic acid, 3β-acetoxy-copalic acid, 3β-hydroxy-copalic acid and ent-agathic acid were isolated from Copaifera langsdorffii oleoresin. These four compounds were submitted to structural modifications by reduction with hydrogen/palladium, esterification with diazomethane, esterification with methanol/sulfuric acid and conversion into
J. Braz. Chem. Soc.. Publicado em: 2017-06
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19. Use of GC/MS to identify chemical constituents and cytotoxic activity of the leaves of Phoradendron mucronatum and Phoradendron microphyllum (Viscaceae)
ABSTRACT Phoradendron mucronatum and P. microphyllum are plants that found in tropical and subtropical areas, used in traditional medicine and popularly known as mistle-thrush. The aim of this study was to identify the chemical constituents of different leaf extracts from P. mucronatum and P. microphyllum and assess cytotoxic activity against strains from a
An. Acad. Bras. Ciênc.. Publicado em: 2017-06
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20. Utilization of dynamic light scattering to evaluate Pterodon emarginatus oleoresin-based nanoemulsion formation by non-heating and solvent-free method
Abstract Pterodon emarginatus Vogel, Fabaceae, is a great source of bioactive compounds. The most known and studied herbal derivative from this species is an ambar-colored oleoresin that contains vouacapane diterpenes and volatile terpenoids, such as β-caryophyllene. Some recent papers aimed to generate nanoemulsions using this oleoresin for biological appl
Rev. bras. farmacogn.. Publicado em: 2017-06
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21. Diterpenes and a new benzaldehyde from the mangrove plant Rhizophora mangle
ABSTRACT This work describes the isolation, by high-speed counter-current chromatography, of the diterpenes manool, jhanol and steviol and the benzaldehyde p-oxy-2-ethylhexyl benzaldehyde from the stilt roots hexane extract of the mangrove plant Rhizophora mangle L., Rhizophoraceae. For this, a non-aqueous biphasic solvent system composed of hexane–acetoni
Rev. bras. farmacogn.. Publicado em: 2017-04
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22. Euphorbia umbellata bark extracts – an in vitro cytotoxic study
ABSTRACT Euphorbia umbellata (Pax) Bruyns, Euphorbiaceae, is commonly used in folk medicine of southern Brazil to treat several kinds of cancer. The latex (part of the plant used for this purpose) is mixed with water and taken as treatment; but this matrix contains toxic potential related to the presence of some phorbol type diterpenes. So the aim of this st
Rev. bras. farmacogn.. Publicado em: 2017-04
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23. RECUPERAÇÃO DE SESQUITERPENOS DO ÓLEO-RESINA DE COPAÍBA A PARTIR DA DESTILAÇÃO MOLECULAR
Copaiba oil-resin has aromatic characteristics and pharmacological activities attributed to sesquiterpenes compounds. These purified compounds present application in perfume, pharmaceutical and cosmetic industries. Therefore, the objective of this work was to use molecular distillation to recover and purify sesquiterpenes of the copaiba oil-resin with purity
Quím. Nova. Publicado em: 2016-08
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24. Synthesis, in vitro Antimalarial Activity and in silico Studies of Hybrid Kauranoid 1,2,3-Triazoles Derived from Naturally Occurring Diterpenes
We herein report the synthesis of hybrid kauranoid molecules of type 1,2,3-triazole-1,4-disubstituted aiming to improve the antimalarial activity of kaurenoic and xylopic acids. The CuI-catalyzed cycloaddition of azides and kauranoid terminal alkynes was explored as a hybridization strategy. Kauranoid terminal alkynes were prepared from kaurenoic and xylopic
J. Braz. Chem. Soc.. Publicado em: 2016-03