Diterpenes
Mostrando 25-36 de 116 artigos, teses e dissertações.
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25. New Terpenoids from Croton limae (Euphorbiaceae)
An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of
Croton limae , along with kaempferol-3-O -glucoside, ombuin- 3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-11J. Braz. Chem. Soc.. Publicado em: 2015-08
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26. DADOS ESPECTROSCÓPICOS DE DITERPENOS LABDÂNICOS: UMA ANÁLISE TEÓRICA VIA RMN E DFT
Labdane diterpenes exhibit important bioactivities such as cardiovascular effects in rats as well as effects in the treatment of autoimmune diseases and Alzheimer syndrome. Recently, the labdane diterpenes
ent -13-epi -manoil oxide, ribenone and ribenol were isolated fromCroton palanostigma . The computatioQuím. Nova. Publicado em: 2015-06
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27. Biotransformation of the Diterpene Ent-18,19-dihydroxytrachylobane by Rhizopus stolonifer
The diterpene ent-18,19-dihydroxytrachylobane was biotransformed for the first time by Rhizopus stolonifer, and yielded the new ent-11β,18,19-trihydroxytrachylobane derivative besides the new ent-kaur-11-ene diterpenes ent-16α,18,19-trihydroxykaur-11-ene and ent-18,19-dihydroxy-16α-methoxykaur-11-ene. Their structures were determined by spectrometric meth
J. Braz. Chem. Soc.. Publicado em: 2015-05
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28. Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance. Semisynthet
Mem. Inst. Oswaldo Cruz. Publicado em: 2015-04
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29. Abietane Diterpenes from Hyptis crassifolia Mart. ex Benth. (Lamiaceae)
O estudo fitoquímico do extrato etanólico das raízes de Hyptis crassifolia Mart. ex Benth.(Lamiaceae) levou ao isolamento e elucidação estrutural de nove diterpenos identificados como 11,12,15-tri-hidroxi-8,11,13-abietatrien-7-ona, 6α,11,12,15-tetra-hidroxi-8,11,13-abietatrien-7‑ona,
J. Braz. Chem. Soc.. Publicado em: 2015-01
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30. Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium
Hedychium coronarium J. Koenig, Zingiberaceae, is a medicinal plant popularly used to treat inflammatory conditions in different countries. Three labdane diterpenes [isocoronarin D (1), methoxycoronarin D (2), ethoxycoronarin D (3)] and benzoyl eugenol (4) were isolated from rhizomes and their chemopreventive potential was evaluated using in vitro assays, n
Rev. bras. farmacogn.. Publicado em: 2014-08
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31. Estudo químico das folhas de Trichilia silvatica (Meliaceae)
From the leaves of a specimen of Trichilia silvatica Meliaceae, eight known compounds were isolated, namely, two pregnanes, 2α,3β,4β-trihydroxypregnan-16-one (1) and 2β,3β,4β-trihydroxypregnan-16-one (2), three diterpenes, cneorubine X (3), kolavelool (4) and kolavenol (5), in addition to γ-tocopherol, 3-O-β-D-glucopyranosyl-β-sitosterol and 3-O-β-
Quím. Nova. Publicado em: 2014
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32. Terpenos em cupins do gênero Nasutitermes (Isoptera, Termitidae, Nasutitermitinae)
The chemical composition of the front gland of termites has been studied for over 40 years. The genus Nasutitermes, considered the most evolved of the Termitidae family, has a peculiarity that sets it apart from the others: a caste of soldiers that carry a terpenic mixture used in defense. This secretion is formed by mono, sesqui and diterpenes from trinervi
Quím. Nova. Publicado em: 2014
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33. Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
Several species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dich
Rev. bras. farmacogn.. Publicado em: 20/08/2013
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34. Changes in the essential oil composition of leaves of Echinodorus macrophyllus exposed to
Leaves of Echinodorus macrophyllus (Kunth) Micheli, Alismataceae, were exposed to different doses of γ-radiation (0.00, 1.00, 3.00, 5.00, 10.00, and 20.00 kGy) and the chemical composition of their essential oils was investigated. The extractive process of the essential oil was more favored when the leaves were irradiated. The essential oil components were
Rev. bras. farmacogn.. Publicado em: 02/08/2013
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35. Pyrrolizidine alkaloids and diterpenes from Villasenoria orcuttii
O estudo químico da Villasenoria orcuttii, a única espécie do gênero Villasenoria, levou ao isolamento de três diterpenos acíclicos, dois deles descritos pela primeira vez. Dois alcaloides pirrolizidínicos, florosenina e floridanina, entre outros compostos já conhecidos, também foram isolados. A configuração absoluta da floridanina foi determinada
J. Braz. Chem. Soc.. Publicado em: 2013-07
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36. Isolation and HPLC quantitation of kaurane-type diterpenes and cinnamic acid derivatives of long-term stored leaves of Mikania laevigata and Mikania glomerata
As folhas de Mikania laevigata e Mikania glomerata são usadas no Brasil para tratar afecções respiratórias, sendo diterpernos caur ânicos e cumarina considerados os constituintes bioativos. O presente estudo relata a investigação dos perfis por CLAE-DAD e os teores de cumarina (1), ácidos trans-o-coumárico (2), caurenóico (3), benzoilgrandiflórico
An. Acad. Bras. Ciênc.. Publicado em: 10/05/2013