Controlled Drug Delivery
Mostrando 25-36 de 97 artigos, teses e dissertações.
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25. Mechanism of controlled release kinetics from medical devices
Utilization of biodegradable polymers for controlled drug delivery has gained immense attention in the pharmaceutical and medical device industry to administer various drugs, proteins and other bio-molecules both systematically and locally to cure several diseases. The efficacy and toxicity of this local therapeutics depends upon drug release kinetics, which
Brazilian Journal of Chemical Engineering. Publicado em: 2010-06
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26. Metronidazole release using natural rubber latex as matrix
Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically
Materials Research. Publicado em: 2010-03
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27. An effective device for generating alginate microcapsules
An alternative approach to somatic gene therapy is to deliver the therapeutic protein by implanting genetically modified cells that could overexpress the gene of interest. Microencapsulation devices were designed to protect cells from host rejection and prevent the foreign cells from spreading while allowing protein secretion. Alginate microcapsules form a s
Publicado em: 2010
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28. Copolímeros biodegradáveis com potencial uso como biomateriais / Biodegradable Copolymers with Potential use as Biomaterials
With the goal of obtaining a new class of biodegradable copolyesters with improved properties isosorbide succinate (IS) moieties were incorporated into the poly(L-lactide), PLLA, backbone. Three miscible block copolymers and one miscible random copolymer with both hydrophobic character and final degradation temperature higher than PLLA and possessing low ave
Publicado em: 2009
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29. IMMOBILIZATION AND RELEASE STUDY OF A RED ALGA EXTRACT IN HYDROGEL MEMBRANES / Estudo da incorporação e liberação de um extrato de algas vermelhas em membranas de hidrogel
In pharmaceutical technology hydrogel is the most used among the polymeric matrices due to its wide application and functionality, primarily in drug delivery system. In view of the large advance innovations in cosmetic products, both through the introduction of new active agents as the matrices used for its controlled release, the objective of this study was
Publicado em: 2009
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30. Protein decorated Nanoparticules : Small Unilamellar Lipid Vesicules and Block Copolymers Micelles. / Nanoparticules Décorées par des Protéines : Vésicules Lipidiques Unilamellaires et Micelies à Base de Copolymères à Blocs
The formation of protein Annexin-A5 decorated (bio-functionalized) nanoparticles is of particular interest in micelle-mediated target drug delivery, in vivo magnetic resonance imaging, or controlled fabrication of biochips. This work describes an easy access to the synthesis and manipulation of block copolymer nano-objects exhibiting binding ability for the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/07/2008
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31. Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SE
Brazilian Journal of Chemical Engineering. Publicado em: 2008-06
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32. Filmes nanoestruturados contendo lipossomos para liberação controlada do Ibuprofeno / Nanostructured films containing liposomes for controlled release of ibuprofen
Controlled drug delivery is a key issue in a number of nanotechnology endeavors owing to the large impact on society that may achieved if improved systems are created which allows for delivery at a specific target and with a controlled rate. Among the various paradigms employed in drug delivery, the use of liposomes is prominent because a variety of drug mol
Publicado em: 2008
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33. Polymeric coating and pharmacokinetic of chitosan granules containing ddI incorporated in microparticles / Revestimento polimerico e farmacocinetica de granulos gastrorresistentes contendo didanosina incorporada em microparticulas de quitosana
This work studied the production and pharmacokinetic of a new pharmaceutical formulation of the didanosine (ddI) drug ,composed by chitosan granules containing ddI incorporated in microparticles, for oral administration in the AIDS therapy. The advantages of this new pharmaceutical formulation compared to the conventional one are: to assure ddI stability in
Publicado em: 2008
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34. Phase equilibrium and structural characterizarion of systems composed by polyanions and cationic surfactants / Equilibrio de fases e caracterização estrutural de sistemas contendo polianions e surfatantes cationicos
Polieletrólitos associam-se fortemente com surfatantes de carga oposta em meio aquoso, levando a uma separação de fases que resulta em uma fase concentrada, rica em polieletrólito e surfatante, em equilíbrio com uma fase diluída constituída pelos contra-íons. A fase concentrada pode ser constituída de interessantes estruturas supramoleculares advind
Publicado em: 2008
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35. Aspectos químicos e fotoquímicos de liberação controlada de óxido nítrico a partir de complexos nitrosilos de rutênio: ensaios farmacológicos e de citotoxicidade. / Chemical and photochemical aspects of control nitric oxide release from nitrosyl ruthenium complexes: pharmacological and cytotoxic assays.
Nitric oxide (NO) is a multipurpose biological agent that shows important role in brain, arteries, immunological system, liver and lungs. The NO basal level alterations have correlation with several diseases as hypertension, cancer, Raymonds disease and platelet aggregation. Aiming supply this deficient NO level, it was necessary propose new compounds that c
Publicado em: 2008
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36. Desenvolvimento, caracterizaÃÃo e estudo de permeaÃÃo cutÃnea de diclofenaco de dietilamÃnio em sistemas tÃpicos nanoemulsionados
The nanoemulsions (NE) are transparent, isotropic and thermodynamically stable systems, formed spontaneously under a specific set of experimental conditions from mixtures of water and oil phases stabilized by a surfactant or a mixture of surfactant and cosufactant. Because of their properties, especially the ability to carry lipophilic and hydrophilic drugs
Publicado em: 2008