Controlled Drug Delivery
Mostrando 13-24 de 97 artigos, teses e dissertações.
-
13. Antifungal efficacy of amphotericin B encapsulated fibrin microsphere for treating Cryptococcus neoformans infection in Swiss albino mice
Abstract A natural and biocompatible fibrin microsphere is one of the most promising dual delivery vehicle as compared to other traditionally designed delivery modalities. It represents sustained delivery of encapsulated drug and is easily biodegradable in the blood circulation. In the present study, we evaluated the systemic augmentation of the antifungal a
Braz J Infect Dis. Publicado em: 2016-08
-
14. Functionalized Multi Walled Carbon Nanotubes as a Carrier for Doxorubicin: Drug Adsorption Study and Statistical Optimization of Drug Loading by Factorial Design Methodology
Multi walled carbon nanotubes (MWNTs) have been identified as an efficient drug carrier. Here a controlled drug delivery system based on modified MWNTs with polyethylene glycol (PEG) was developed (MWNTs-PEG). Then doxorubicin (DOX) as an anticancer drug loaded to nanocarrier. All the parameters affecting the DOX adsorption such as: dose of adsorbent, pH, in
J. Braz. Chem. Soc.. Publicado em: 2016-04
-
15. Microporous Nano-hydroxyapatite/collagen/phosphatidylserine Scaffolds Embedding Collagen Microparticles for Controlled Drug Delivery in Bone Tissue Engineering
AbstractScaffolds featuring spatiotemporal control of drug release is highly desirable for bone tissue regeneration. The objective of this study was to construct a scaffold with gradient porosity and drug distribution and evaluate the effect of scaffold structure on drug release kinetics and cell bioactivity. Nano-hydroxyapatite/collagen/phosphatidylserine s
Mat. Res.. Publicado em: 2015-10
-
16. Antifungal effect of electrospun nanofibers containing cetylpyridinium chloride against Candida albicans
It is known that cetylpyridinium chloride (CPC) has in vitro and in vivo antifungal action against Candida albicans, with advantages over other common antiseptics. A CPC delivery-controlled system, transported in polymer nanofibers (PVP/PMMA), was developed to increase the bioavailability of the drug in contact with the oral mucosa. The objectives of this st
Braz. oral res.. Publicado em: 15/09/2014
-
17. Effect of tamoxifen in RAFT miniemulsion polymerization during the synthesis of polymer nanoparticles
Tamoxifen (TXF) is currently the only hormonal agent used for treatment of breast cancer. Although very effective, TXF presents low solubility in water, which affects its absorption and bioavailability. A common strategy to overcome this barrier is the formulation of a drug delivery system (DDS) in order to increase the drug stability and improve the treatme
Polímeros. Publicado em: 27/05/2014
-
18. Biodegradable sodium alginate and lignosulphonic acid blends: characterization and swelling studies
In this article, Sodium alginate and Lignosulphonic acid blends were prepared in different weight ratios by solution casting method. Swelling experiments were conducted for Sodium alginate and its blends by adding calcium chloride for various intervals in a pH 7.4 medium. The strength of the films increases after their treatment with CaCl2 at higher interval
Polímeros. Publicado em: 01/02/2013
-
19. Fosfatos de cálcio mesoporosos e como nanocompósitos com sílica: síntese, caracterização e ensaios de liberação controlada de fármaco / Mesoporous calcium phosphates and as silica nanocomposites: synthesis, characterization and controlled drug delivery essay
A principal aplicação dos fosfatos de cálcio é como biomateriais, para serem usados como enxerto ou implante ósseo. A obtenção de biocerâmicas mesoporosas permitiu o uso destes materiais como carreadores de fármacos, que são incorporados à estrutura porosa para serem subsequentemente liberados de forma controlada do enxerto ou implante ósseo para
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/09/2011
-
20. Obtaining and characterization of simvastatin loaded PLDLA microspheres / Obtenção e caracterização de microesferas de PLDLA carregadas com sinvastatina
Dispositivos de liberação controlada de fármacos têm sido indicados por profissionais da saúde como uma alternativa para aumentar a eficácia terapêutica de medicamentos assim como a adesão dos pacientes ao tratamento. Polímeros biorreabsorvíveis, seus copolímeros e blendas têm apresentado vantagens em relação a outros polímeros por serem: bioc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/07/2011
-
21. Alginate/hydrophobic HPMC (60M) particulate systems: new matrix for site-specific and controlled drug delivery
Este estudo teve como objetivo a obtenção de sistemas particulados para a liberação controlada de fármacos em sítios de ação específicos. Algumas partículas foram preparadas utilizando-se diferentes concentrações de alginato de sódio (Na-Alg) e outras foram formuladas por diferentes proporções de Na-Alg com estearoxílico éter de hidroxipropi
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2011-12
-
22. Preparation and application of chitosan nanoparticles and nanofibers
Encapsulation and immobilization technology is important for the food processing and bioengineering industries. Chitosan is a natural polysaccharide prepared by the N - deacetylation of chitin. It has been widely used in food and bioengineering industries, including the encapsulation of active food ingredients, in enzyme immobilization, and as a carrier for
Brazilian Journal of Chemical Engineering. Publicado em: 2011-09
-
23. Aplicação de quitosana como suporte para a imobilização de enzimas de interesse industrial
Chitosan, poly[β-(1-4)-linked-2-amino-2-deoxy-D-glucose], is the N-deacetylated product of chitin which is a major component of arthropod and crustacean shells such as lobsters, crabs, shrimps, and cuttlefishes. In addition, chitosan has many significant biological and chemical properties such as biodegradability, biocompatibility and bioactivity as well as
Química Nova. Publicado em: 2011
-
24. Hidroxiapatita mesoporosa pura e modificada organicamente com grupos nitrogenados síntese, caracterização e uso como carreadora de fármacos / Pure Mesoporous Hydroxyapatite and Modified Organically with Nitrogen-containing Groups - Synthesis, Characterization and Use as Drug Delivery Materials
Materiais mesoporosos apresentam um arranjo de poros ordenados e uma distribuição de poros muito estreita aliada a altas áreas superficiais, que são características estruturais interessantes para adsorção e liberação de moléculas bioativas. Outra característica relevante desses sólidos é a presença dos grupos hidroxilas livres nas paredes dos p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/10/2010