Controlled Drug Delivery
Mostrando 37-48 de 97 artigos, teses e dissertações.
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37. Rapid manufacturing of polyethylene parts with controlled pore size gradients using selective laser sintering
In this study HDPE specimens were fabricated by selective laser sintering using different particle sizes to obtain controlled variations in the porosity. Electron microscopy, density measurements and mechanical analyses were conducted for the characterization of the specimens. Parts with controlled pore gradients were also manufactured and characterized. The
Materials Research. Publicado em: 2007-06
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38. Dipropionato de beclometasona em formulação lipossomal como po inalavel para o tratamento de doenças pulmonares
The liposomal drug encapsulation for medical applications is in many instances the most efficient way to ensure good storage, transport, targeting, and controlled release of the drug, thus reducing toxicity. Liposomes have been extensively studied as vehicles for efficient drug delivery. The objective of the present work is to develop a formulation of the co
Publicado em: 2007
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39. Estudo de metalofármacos antiinflamatórios de cobre e dos materiais híbridos resultantes de suas imobilizações no hidróxido duplo lamelar hidrotalcita: síntese, caracterização e avaliação da atividade farmacológica / Studies of Anti-inflammatory Copper-based Drugs and Corresponding Hybrid Materials from their Immobilization on the Layered Double Hydroxide Hydrotalcite: Synthesis, Characterization and Evaluation of Pharmacological Activities
Non-steroidal anti-inflammatory drugs are widely consumed to treat inflammatory diseases and pain but their clinical use are limited due to serious side-effects on the gastrointestinal tract. The bioactivity of metal complexes exhibits great interest in metal-based drug research. Cu(II)-NSAID compounds show good anti-inflammatory property and decreased side-
Publicado em: 2007
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40. Solubility of dense CO2 in two biocompatible acrylate copolymers
Biocompatible polymers and copolymers are frequently being used as part of controlled delivery systems. These systems can be prepared using a "clean and environment friendly" technology like supercritical fluids. One great advantage of this process is that compressed carbon dioxide has excellent plasticizing properties and can swell most biocompatible polyme
Brazilian Journal of Chemical Engineering. Publicado em: 2006-06
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41. Materiais mesoporosos ordenados aplicados como sistemas para liberação controlada de drogas / Ordered mesoporous materials applied as drug delivery systems
In the last decade, progress in the development of nanosized hybrid therapeutics and drug delivery systems has been remarkable. Mesoporous materials such as SBA-15 and MCM-41 have been considered very promising materials for hosting and further delivery of biological agents within silica samples and for controlling their release kinetics from the matrix due
Publicado em: 2006
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42. Desenvolvimento de formas lipossomais contendo levana
The present study proposes the manufacture of liposomes containing levan as an antitumor and immunomodulator for the cancer therapy. Levan-loaded liposomes (Lev-LIPO) were prepared according to the thin film formed method. Physicochemical characterization was performed immediately after their preparation. Additionally, both accelerated and long-term stabilit
Publicado em: 2006
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43. Preparo, caracterização e perfil de liberação in vitro de microesferas de sílica processadas por spray drying
In this study, the release rate of cyanocobalamin from different sol-gel spray-dried silica microspheres formulations was investigated. The drug was incorporated into a sol phase of a silica precursor, tetraethyl orthosilicate (TEOS), before spray drying with a Büchi laboratory scale equipment. The effects of the sol phase pH, the drug loading, the water/al
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/12/2005
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44. Desenvolvimento e avaliação farmacologica de formulações de liberação controlada com anestesicos locais amino-amidas ciclicos : bupivacaina, mepivacaina e ropivacaina / Development and pharmacological evaluation of drug-delivery systems for cyclic amino-amide local anesthetics: bupivacaine, mepivacaine and ropivacaine
Local anesthetics (LA) are among the different classes of pharmacological compounds used to attenuate or to eliminate pain. These drugs, which are able to reversibly block the excitation/transmission of the nerve impulse in axons have a relatively short action and a significant toxicity to the Central Nervous and Cardiovascular systems. In order to prolong t
Publicado em: 2005
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45. Mutual diffusion coefficient models for polymer-solvent systems based on the Chapman-Enskog theory
There are numerous examples of the importance of small molecule migration in polymeric materials, such as in drying polymeric packing, controlled drug delivery, formation of films, and membrane separation, etc. The Chapman-Enskog kinetic theory of hard-sphere fluids with the Weeks-Chandler-Andersen effective hard-sphere diameter (Enskog-WCA) has been the mos
Brazilian Journal of Chemical Engineering. Publicado em: 2004-12
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46. Sulfated fucan as support for antibiotic immobilization
Xylofucoglucuronan from Spatoglossum schröederi algae was tested as a support for antibiotic immobilization. The polysaccharide (20 mg in 6 ml) was first activated using carbodiimide, 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide methiodide (20 mg in 2 ml), under stirring for 1 h at 25ºC and pH from 4.5 to 5.0. After adjusting the pH to 8.0, either gentam
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03
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47. Atividade antitumoral e toxicidade de nanocÃpsulas contendo o Ãcido fumarprotocetrÃrico isolado dec(lÃquen)
The potential of controlled release in optyimizing drug targeting has offered a tremendous advancement in the manipulation of novel dosage forms such as nanoparticles, wich are solid colloidal polymeric carriers in size range of 1-1,000 nm. Oil-in-water microemulsions as a drug delivery system include improvement of drug solubilization. The fumarprotocetrari
Publicado em: 2004
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48. Estudo do processo de produção de particulas lipidicas solidas e lipossomas : estudo de variaveis e encapsulação de medicamentos de primeiro tratamento da tuberculose
This work presents scale up studies for the production of so1id lipid particles (respirable powders) and liposomes, which are useful as vehic1es for contro1led delivery of rugs. The lipid particles were produced by spray drying, and the liposomes were prepared by hydration of the particles under high shear mixing. It was used a hydrogenated phospholipid, Epi
Publicado em: 2003