Bioinformatic
Mostrando 25-36 de 175 artigos, teses e dissertações.
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25. Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients
The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being recognized in Brazilian and French patients, respectively. The GPGR (P) motif was predominant in French but not in Brazilian patients (53.5% vs
Brazilian Journal of Microbiology. Publicado em: 2010-10
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26. Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene
Myocardial ischemic preconditioning up-regulated protein 1 (Mipu1), a novel zinc finger protein, was originally cloned using bioinformatic analysis and 5' RACE technology of rat heart after a transient myocardial ischemia/reperfusion procedure in our laboratory. In order to investigate the functions of Mipu1, the recombinant prokaryotic expression vector pQE
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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27. Expression, purification and characterization of surface proteins from Leptospira interrogans. / Expressão, purificação e caracterização de proteínas de superfície de Leptospira interrogans.
The whole-genome sequences of L. interrogans serovar Copenhageni and the bioinformatic tools allow us to choose fifteen genes encoding for conserved hypothetical proteins predicted to be exported to the membrane. The chosen genes were amplified by PCR from six predominant pathogenic serovars, the DNA cloned in an E. coli vector, the recombinant proteins expr
Publicado em: 2009
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28. D-MaPs - DNA-microarray projects: web-based software for multi-platform microarray analysis
The web application D-Maps provides a user-friendly interface to researchers performing studies based on microarrays. The program was developed to manage and process one- or two-color microarray data obtained from several platforms (currently, GeneTAC, ScanArray, CodeLink, NimbleGen and Affymetrix). Despite the availability of many algorithms and many softwa
Genetics and Molecular Biology. Publicado em: 2009
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29. AnÃlise computacional de genes associados ao metabolismo de fixaÃÃo de nitrogÃnio no feijÃo-caupi (Vigna unguiculata) e cana-de-aÃÃcar (Saccharum spp.)
The biological nitrogen fixation has been one of the main targets in what refers to plantsâ mineral nutrition, being explored in agriculture as an environmentally benign nitrogen source besides the fact that it can reduces the use of chemical fertilizers, which increases the cost of the production and causes damages to the environment. In this context, the
Publicado em: 2009
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30. Interaction of the nuclear receptors with its ligands: Structural studies of the thyroid hormone receptor, mineralocorticoid receptor and peroxisome proliferator-activated receptor / Interações dos receptores nucleares com seus ligantes: Estudos estruturais do receptor de hormônio tireoidiano, do receptor de mineralocorticóide e do receptor ativado por proliferadores peroxissomais
Nuclear receptors are a superfamily of hormone-regulated transcriptional factors. This superfamily includes, for example, the receptor for thyroid hormone, estrogen, androgen, gluco and mineralocorticoid. In this work, we used structural biology and bioinformatic tools to study the interactions between some members of the nuclear receptor superfamily and its
Publicado em: 2009
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31. Identificação e caracterização funcional dos elementos cis-regulatorios da miostatina / Identification and functional characterization of the cis-regulatory elements of myostatin
The Myostatin protein (also known as GDF8) is a member of the transforming growth factor-β (TGF-β) superfamily and is expressed almost exclusively in skeletal muscle, both in the embryo and in the adult, where the protein circulates in the blood flow. It was initially identified in 1997 by MCPHERRON et al., and since then many studies have been dem
Publicado em: 2009
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32. Produção, caracterização funcional e imunogênica de uma proteína dermonecrótica recombinante 9recLiD1) da aranha Loxosceles intermédia
In the present study the recombinant form (rLiD1) of a dermonecrotic protein from the Brazilian Loxosceles intermedia spider venom was expressed in Escherichia coli and purified by reversed-phase HPLC. Twenty five mg of rLiD1 was produced from liter of bacterial culture. The molecular weight of rLiD1 was verified by mass spectrometry (32,758 Da). rLiD1 displ
Publicado em: 2008
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33. VISTREE: uma linguagem visual para análise de padrões arborescentes e para especificação de restrições em um ambiente de mineração de árvores
The frequent pattern mining in data represented by more complex structures like trees and graphs are growing lately. Among the reasons for this improvement is the fact that the tree and graph patterns has more information than sequential patterns, besides there is the possibility of usage of this type of mining in several areas like XML Mining,Web Mining and
Publicado em: 2008
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34. Re-mapping the molecular features of the human immunodeficiency virus type 1 and human T-cell lymphotropic virus type 1 Brazilian sequences using a bioinformatics unit established in Salvador, Bahia, Brazil, to give support to the viral epidemiology studies
The analysis of genetic data for human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type 1 (HTLV-1) is essential to improve treatment and public health strategies as well as to select strains for vaccine programs. However, the analysis of large quantities of genetic data requires collaborative efforts in bioinformatics, computer
Memórias do Instituto Oswaldo Cruz. Publicado em: 23/02/2007
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35. Mineração de regras para classificação de oncogenes medidos por microarray utilizando algoritmos genéticos
Artificial Intelligence techniques are increasing their role in the solution of biological problems. The present study use a Genetic Algorithm (GA) in the search for high level IF-THEN rules. This GA was applied to miner classification rules from a gene expression database named NCI60. This database was developed using cancer cells measured by microarray. Th
Publicado em: 2007
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36. MineraÃÃo de regras para classificaÃÃo de oncogenes medidos por microarray utilizando algoritmos genÃticos
TÃcnicas de InteligÃncia Artificial (IA) tÃm se tornado cada vez mais importantes na soluÃÃo de problemas biolÃgicos. Nesta dissertaÃÃo, utilizamos um Algoritmo GenÃtico (AG) na busca de regras de alto nÃvel do tipo IF-THEN. Este AG foi aplicado na mineraÃÃo de regras de classificaÃÃo em uma base de dados de expressÃo gÃnica de cÃlulas cance
Publicado em: 2007