Bioinformatic
Mostrando 13-24 de 175 artigos, teses e dissertações.
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13. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax
The PfCLAG9 has been extensively studied because their immunogenicity. Thereby, the gene product is important for therapeutics interventions and a potential vaccine candidate. Antibodies against synthetic peptides corresponding to selected sequences of the Plasmodium falciparum antigen PfCLAG9 were found in sera of falciparum malaria patients from Rondônia,
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
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14. Immunologic cross-reactivity between Muscovy duck parvovirus and goose parvovirus on the basis of epitope prediction
Through bioinformatic prediction, between Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV), there were one epitope AA503-509 (RANEPKE) on non-structural protein and three epitopes AA426-430 (SQDLD), 540-544 (DPYRS), 685-691 (KENSKRW) on structural protein might cross-react with each other. Furthermore, the four epitops were expressed in Escherichia
Braz. J. Microbiol.. Publicado em: 2013
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15. Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas / Integrative Analysis of Transcriptional Profiles in Type 1, Type 2 and Gestational Diabetes Mellitus, Compared with Demographic, Clinical, Laboratory, Physiopathology and Therapeutic Manifestations.
O diabetes mellitus tipo 1 (DM1) tem etiologia autoimune, enquanto o diabetes mellitus tipo 2 (DM2) e o diabetes mellitus gestacional (DMG) são considerados como distúrbios metabólicos. Neste trabalho, foi realizada análise do transcriptoma das células mononucleares do sangue periférico (do inglês, peripheral mononuclear blood cells - PBMCs), obtidas
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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16. The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide
Ascorbate peroxidases (APX) are class I heme-containing enzymes that convert hydrogen peroxide into water molecules. The gene encoding APX has been characterized in 11 strains of Trypanosoma cruzi that are sensitive or resistant to benznidazole (BZ). Bioinformatic analysis revealed the presence of two complete copies of the T. cruzi APX (TcAPX) gene in the g
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-06
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17. Identification of Albizia lebbeck seed coat chitin-binding vicilins (7S globulins) with high toxicity to the larvae of the bruchid Callosobruchus maculatus
Seed coat is a specialized maternal tissue that interfaces the embryo and the external environment during embryogenesis, dormancy and germination. In addition, it is the first defensive barrier against penetration by pathogens and herbivores. Here we show that Albizia lebbeck seed coat dramatically compromises the oviposition, eclosion and development of the
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
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18. Influência dos polimofismos de nucleotídeo único (SNPs) da APOBEC3G na dinâmica populacional da infecção pelo HIV-1 / Influence of single nucleotide polymorphisms of APOBEC3G in the population dynamic in the HIV-1 infection
APOBEC3G (A3G) has been described as a cellular factor that inhibits replication of HIV-1. During reverse transcription, A3G promotes deamination of cytidine to uracil in the minus strand viral DNA, inducing hypermutation of guanines to adenines in plus strand DNA. The HIV-1 counters this effect by the activity of the viral protein Vif, which counteracts A3G
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011
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19. Uso de Data Mining na descoberta ou identificação de regras de enovelamento baseado em perfis de hidrofobicidade / Use of Data Mining in the discovery or identification of folding rules based on hydrophobicity profiles
As proteínas são moléculas complexas encontradas em células vivas. Elas possuem uma estrutura terciária (tridimensional) específica que determina sua função e é necessária para a ligação específica de substratos ou outros ligantes. A estrutura de uma proteína pode ser organizada em quatro níveis hierárquicos: estrutura primária (sequência d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/03/2011
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20. Identification of Schistosoma mansoni candidate antigens for diagnosis of schistosomiasis
The development of a more sensitive diagnostic test for schistosomiasis is needed to overcome the limitations of the use of stool examination in low endemic areas. Using parasite antigens in enzyme linked immunosorbent assay is a promising strategy, however a more rational selection of parasite antigens is necessary. In this study we performed in silico anal
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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21. Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity
Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in
Genetics and Molecular Biology. Publicado em: 19/08/2011
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22. A bioinformatics approach to detect interchromosomal trans-splicing in bovine full length cDNA databanks.
Trans-splicing is an unusual form of RNA processing mechanism where distinct pre-mRNA sequences contribute to the formation of a single mRNA. It is common in nematodes and kinetoplastids, but it is rare in superior organisms. Nevertheless, some recent studies show that trans-splicing, although rare, may be more widespread than believed (Gingeras). Consequent
PLANT & ANIMAL GENOME CONFERENCE. Publicado em: 2011
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23. Avaliação de parâmetros bioquímicos e comportamentais em peixe-zebra (Danio rerio) : uma abordagem sobre o sistema purinérgico, colinérgico e efeitos promovidos pela taurina no modelo de exposição aguda ao etanol
The zebrafish (Danio rerio) is a small teleost fish that belongs to the Cyprinidae family, which has been studied in different scientific areas. This species has evolutively conserved genes, several neurotransmitter systems characterized, and a wide behavioral repertoire, which may be modulated by distinct drugs. Thus, this thesis aims to study biochemical p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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24. Determination of HIV-1 coreceptor usage by CCR5 and CXCR4 coreceptors using bioinformatic tools / Determinação do tropismo do HIV-1 pelos correceptores CCR5 e CXCR4 pelo uso de ferramentas de bioinformática.
A sequência de 35 aminoácidos da alça V3 da gp120 do gene env do HIV-1 é o principal determinante do tropismo viral pelos correceptores CCR5 ou CXCR4, utilizados pelo HIV-1 para a entrada na célula. O desenvolvimento de estratégias antirretrovirais baseadas no uso dos correceptores representa um avanço importante para o controle da progressão da infe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/05/2010