Bioequivalence
Mostrando 37-48 de 91 artigos, teses e dissertações.
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37. Liquid chromatography-mass spectrometry method for determination of methotrexate in human plasma / Estudo de biodisponibilidade relativa entre duas formulações de metotrexato em plasma humano utilizando cromatografia liquida acoplada a espetrometria de massas em serie
A rapid, sensitive and specific method was developed for the determination and quantitation of methotrexate, in human blood plasma by liquid chromatography coupled with tandem mass spectrometry using calcium folinate as internal standard. Methotrexate was extracted from 0,2 mL human plasma by protein precipitation procedure using acetonitrile as eluent. The
Publicado em: 2007
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38. Liquid chromatography-mass spectrometry method for determination of methotrexate in human plasma / Estudo de biodisponibilidade relativa entre duas formulações de metotrexato em plasma humano utilizando cromatografia liquida acoplada a espetrometria de mass em serie
A rapid, sensitive and specific method was developed for the determination and quantitation of methotrexate, in human blood plasma by liquid chromatography coupled with tandem mass spectrometry using calcium folinate as internal standard. Methotrexate was extracted from 0,2 mL human plasma by protein precipitation procedure using acetonitrile as eluent. The
Publicado em: 2007
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39. Quantificação do 5-mononitrato de isossorbida em plasma humano por cromatografia liquida de alta eficiencia acoplada a espectrometro de massa com fotoionização em pressão atmosferica / Quantification of isosorbide 5-moninitrate in human plasma by liquid chromatography tandem mass spectrometry using atmospheric pressure photoionization
O 5-mononitrato de isossorbida (5-MNIS) é um nitrato orgânico comumente usado no tratamento da angina pectoris em razão de suas propriedades vasodilatadoras. No presente estudo, um novo método foi desenvolvido para determinar e quantificar o 5-MNIS no plasma humano por cromatografia líquida acoplada à espectrometria de massa em série (CLAE-EM-EM), usa
Publicado em: 2007
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40. A new model for the population pharmacokinetics of didanosine in healthy subjects
Didanosine (ddI) is a component of highly active antiretroviral therapy drug combinations, used especially in resource-limited settings and in zidovudine-resistant patients. The population pharmacokinetics of ddI was evaluated in 48 healthy volunteers enrolled in two bioequivalence studies. These data, along with a set of co-variates, were the subject of a n
Brazilian Journal of Medical and Biological Research. Publicado em: 27/11/2006
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41. Avaliação da bioequivalência de comprimidos contendo 10 mg de cloridrato de ciclobenzaprina / Bioequivalence avaliation of tables contain 10 mg of cyclobenzaprine hydrochloride
Cyclobenzaprine is a centrally acting muscle relaxant that has similarity with a tricyclic antidepressant. The purpose of this study was to evaluate the bioequivalence of two brands of cyclobenzaprine 10 mg tablets in healthy volunteers. The procedure of bioequivalence between test product (Miosan®) and reference product (Flexeril®) was a randomized, open
Publicado em: 2006
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42. Estudo de bioequivalencia entre duas formulações de oxcarbazepina de 600mg em voluntarios sadios de ambos os sexos / Bioequivalence study between two 600mg oxcarbazepine formulations in health volunteers of both genders
The purpose of this study was to compare the bioavailability of two oxcarbazepine formulations in 600mg pills - a test formulation produced by Cristália Produtos Químicos Farmacêuticos Ltda with the Trileptal® formulation by Novartis Pharma. Based on the low interindividual variability of this drug and the existing bibliography, the study sample size ind
Publicado em: 2006
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43. Estimation of rosuvastatin in human plasma by HLPC tandem mass spectroscopic method and its application to bioequivalence study
Um método empregando LC-MS/MS foi desenvolvido para a análise de rosuvastatina em plasma humano, usando atorvastatina como padrão interno. Rosuvastatina é um fármaco para redução de lipídeos e prescrita para o tratamento do hipercolesterolemia e de dislipidimia. A extração em fase sólida (SPE) foi usada para purificação e pré-concentração do
Journal of the Brazilian Chemical Society. Publicado em: 2005-10
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44. Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Various synthetic routes to prepare different types of bisphosphonates have been described, with distinct potency and pharmacological activity. A number of analytical techniques are currently being used to analyze
Química Nova. Publicado em: 2005-03
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45. Bioequivalence evaluation of tinidazole 500 mg tablets / Avaliação de bioequivalência de comprimidos contendo 500 mg de tinidazol
Tinidazole, 1-[2-(ethylsulphonyl)ethyl]-2-methyl-5-nitroimidazole, is a member of the 5-nitroimidazole class of antimicrobial agents with amoebicidal, giardicidal, trichomonicidal and anaerobic activity. The purpose of this study was to evaluate the bioequivalence of two brands of tinidazole 500mg tablets in healthy human volunteers. The procedure of bioequi
Publicado em: 2005
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46. Estudo de bioequivalencia de duas formulações de cefadroxil - capsula (500mg) em voluntarios sadios de ambos os sexos
The objective of this study is to compare the bioequivalence of Cefadroxil- capsule 500 mg formulated by Apotex of Brazil Ltda (test formulation) and Cefamox by LaboratoryBristol-Myers Squibb (reference formulation) in volunteers of both sexes. This study was necessary for the commercialization of medicines. The study was conducted with a randomized two-peri
Publicado em: 2005
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47. Estudo de bioequivalencia de duas formulações de cefadroxil - capsula (500mg) em voluntarios sadios de ambos os sexos
The objective of this study is to compare the bioequivalence of Cefadroxil- capsule 500 mg formulated by Apotex of Brazil Ltda (test formulation) and Cefamox by LaboratoryBristol-Myers Squibb (reference formulation) in volunteers of both sexes. This study was necessary for the commercialization of medicines. The study was conducted with a randomized two-peri
Publicado em: 2005
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48. Estudo de bioequivalencia de duas formulações de cefadroxil - capsula (500mg) em voluntarios sadios de ambos os sexos
The objective of this study is to compare the bioequivalence of Cefadroxil- capsule 500 mg formulated by Apotex of Brazil Ltda (test formulation) and Cefamox by LaboratoryBristol-Myers Squibb (reference formulation) in volunteers of both sexes. This study was necessary for the commercialization of medicines. The study was conducted with a randomized two-peri
Publicado em: 2005