RepercussÃes histolÃgicas da esquistossomose mansÃnica em fÃmur de camundongos

AUTOR(ES)

Gerardo Vasconcelos Mesquita

DATA DE PUBLICAÇÃO

2006

RESUMO

Schistosomiasis mansoni is still a worldwide problem. One of the main concerns is the number of patients who develop its hepatosplenic form, which presents portal hypertension as the main reason of morbidity. Bone mineral content (BMC) has been used as a way of evaluating the simultaneously bone involvement. It has been proved, in this disease, BMC deficit and liver function reserve changes, which interfere with calcium and magnesium ions metabolism; and thus making possible that such alterations could be found in the bone structure. The purpose of this study was to evaluate, using histomorphometry, the repercussions of schistosomiasis mansoni in the femur of infected mice. A microscopy study was performed, reporting the histology abnormalities, taking into account the changes in the bone and trabecular areas, before and after 120-day post-infection. The areas were measured by aerophotogrametry and planimetry. âtâ Student test was used for testing significant differences between means. The trabecular and bone areas were greater in the infected mice; however, this difference was only significant for the bone areas (p <0.05). One can conclude that the bone and trabecular areas measured from the femur sections of infected mice were greater than those of the control group. The likely explanation for this finding is the evident reorganization of the bone architecture of the studied slices; which is represented by the presence of osteoblastic activity with cell reorientation around the trabecular bone areas seen in all femur slices from the infected animals. This phenomenon is suggestive of a repair bone try in the bone marrow. The lack of osteoclasts in the femur slices from infected mice could mean that the bone mineral content deficiency, which can be seen, is not induced by the classic osteoporosis. In this way, it is not clear the mechanism that turns on the remodeling bone process, since the known mechanism is directly related to the presence of osteoclasts in the affected area

ASSUNTO(S)

histology camundongos histologia conteÃdo mineral Ãsseo mice schistosomiasis mansoni bone mineral content cirurgia esquistossomose mansÃnica

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