Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae) / Estudo FitoquÃmico e BiolÃgico de Humirianthera ampla Miers (Icacinaceae)

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

23/02/2007

RESUMO

The phytochemical investigation of the roots of Humiranthera ampla (Icacinaceae) resulted in the isolation and identification of a mixture of beta-sitosterol and stigmasterol, annonalide, lupeol and the 3-beta-O-beta-D-glucopyranosyl sitosterol. The structures of these compounds were established by spectrometric analysis (IR, MS, NMR 1H and 13C) including bidimensional NRM techniques (COSY, HMQC, HMBC and NOESY) and for comparison with data described in the literature. All extracts were tested using the Ellman assay. Only ethyl acetate extract and their fractions showed acetylcholinesterase inhibition. The antioxidant capacity of the extracts were measured as method described by Owen et al, 2001. The ethanolic extract was the most active. The ethyl acetate extract showed xanthine oxidase inhibition.

ASSUNTO(S)

quimica organica quÃmica vegetal doenÃa de alzheimer icacinacea plantas - anÃlise

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