Influência da obesidade e da resistência à insulina sobre o desenvolvimento tumoral: efeito da metformina / : Obesity and insulin resistance influences in the tumor development metformin effects

AUTOR(ES)

Eveline Aparecida Isquierdo Fonseca

DATA DE PUBLICAÇÃO

2010

RESUMO

The influence of obesity and insulin resistance (induced in rats by monosodium glutamate in neonates) on tumor development (5x105 Walker-256 tumor cells) and the effect of metformin (300mg/kg, by gavage, for 15 d) on it. On the 16th week, tumor cells were subcutaneously injected and the treatment started. On the 18th week, the obesity was characterized and the tumor was evaluated. The tumor development and the cachexia were higher in obese rats. The tumor development was reduced by metformin, but not cachexia. Although metformin did not improve insulin sensitivity it did correct the dislypidemia, reduced the periepididimal and retroperitoneal adipose tissues and lipid peroxidation. In conclusion obesity increases tumor development and metformin is able to reduce it. The reduction occurred independently of the correction of insulin resistance

ASSUNTO(S)

metformin metformina insulina insulin resistance inflammation neoplasia insulin obesidade inflamação resistência à insulina neoplasias obesity

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