Efficient synthesis of new biheterocyclic 5-[(5-Trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl)-1-propan-1-one-3-yl]-2-methyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidines
AUTOR(ES)
Flores, Alex F. C., Rosales, Pauline F., Malavolta, Juliana L., Flores, Darlene C.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2014-08
RESUMO
Neste trabalho relatamos a ciclocondensação entre a 2-metil-7-trifluorometilpirazolo[1,5-a]pirimidino-5-propanoil hidrazida derivada da 2-metil-5-(metilpropanoato-3-il)-7-trifluorometilpirazolo[1,5-a]pyrimidina e doze versáteis 1,1,1-trifluoro-4-alcóxi-3-alquen-2-onas [F3CC(O)C(R²)=C(R¹)OMe onde R¹ = H, Me, (CH2)2CHCMe2, (CH2)2Ph, (CH2)2CO2Me, Ph, 4-MeC6H4, 4-MeOC6H4, EtO e R² = H; R¹, R² = -(CH2)4-, -(CH2)5-; R¹ = Ph e R² = Me]. A estrutura molecular dos produtos 5-[(5-trifluorometil-5-hidroxi-4,5-diidro-1H-pirazol-1-il)-1-propan-1-ona-3-il]-2-metil-7-trifluorometilpirazolo[1,5-a]pirimidinas, novos bihetererociclos contendo o espaçador propionil, foram atribuídas com base nos dados de ressonância magnética nuclear (NMR) de ¹H, 13C e 19F, e espectrometria de massas (MS).
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