Algumas propriedades de virulência de Escherichia coli isoladas de pacientes com doença inflamatória intestinal. / Some virulence properties of Escherichia coli isolated from patients with inflammatory bowel disease.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Escherichia coli are increased in inflammatory bowel disease (IBD) patients, but the reason for this elevation is unknown. Amongst their properties is the interaction with cultured epithelial cells. Rectal biopsies from 27 ulcerative colitis (UC), 8 Crohns disease (CD) and 19 control patients were cultured for E. coli, given 131 isolates. Enteroagregative E. coli (EAEC) strains, as detected in 3h adherence assays to HEp-2 cells, were found in 71.4% of 35 IBD patients and in 26.3% of controls (P<0.02). Two highly invasive strains were detected among UC patients, three of whom had also strains with both plasmid of aggregative adhesion (pAA) and aggregative adherence fimbriae R (aggR) and another four E. coli attaching and effacing (eae). No strains had invasion-associated locus (ial) and invasion plasmid antigen H (ipaH), and those from CD were also negative for other markers. According to these results, EAEC are the dominant E. coli group found in the colonic mucosa of IBD patients, but only those found in UC patients seem to harbor traditional virulence markers.

ASSUNTO(S)

disease escherichia coli bowel escherichia coli virulence inflamação inflammatory doença intestinal virulência

ACESSO AO ARTIGO

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