Anticoagulant Activity
Mostrando 13-24 de 166 artigos, teses e dissertações.
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13. Anticoagulant activity in salivary gland homogenates of Thyrsopelma guianense (Diptera: Simuliidae), the primary vector of onchocerciasis in the Brazilian Amazon
In this study, anticoagulant activity was detected in salivary gland homogenates (SGHs) of Thyrsopelma guianense (Diptera: Simuliidae). The SGH yielded 1.07 μg ± 0.03 (n = 15) of total soluble protein per pair of glands. In addition, following SDS-PAGE (12.5% gel) and silver nitrate staining, 12 polypeptides with molecular weights ranging from 14-69 kDa we
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-03
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14. Preparação e caracterização de nanoparticulas com heparina e sua avaliação em modelo animal de trombose venosa / Preparation and characterization of heparin-loaded nanoparticles and its evaluation in animal model of venous thrombosis
Heparin is an anticoagulant widely used in the treatment and prophylaxis of deep vein thrombosis (DVT). Some limitations of its use is the cost and route of administration, intravenous or subcutaneous, sometimes in repeated doses in 24 hours. Thus, the development of a product that can be administered subcutaneously in a smaller number of applications or ora
Publicado em: 2010
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15. Effect of collection, transport, processing and storage of blood specimens on the activity of lysomal enzimes in plasma and leukocytes
This study was designed to evaluate the effect of different conditions of collection, transport and storage on the quality of blood samples from normal individuals in terms of the activity of the enzymes ß- glucuronidase, total hexosaminidase, hexosaminidase A, arylsulfatase A and ß-galactosidase. The enzyme activities were not affected by the different ma
Publicado em: 2010
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16. External morphology of Cotesia flavipes (Hymenoptera: Braconidae) during larval development
Cotesia flavipes (Cameron, 1891) (Hymenoptera) is a gregarious endoparasitoid used in applied biological control against Diatraea saccharalis (Fabricius, 1794) (Lepidoptera). In this study, we characterize the larval external morphology and the number of instars of C. flavipes. Parasitized larvae of D. saccharalis were sampled from the 1st to the 10th day af
Zoologia (Curitiba). Publicado em: 2010
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17. Efeito da salinidade da água do mar no rendimento, composição e atividades biológicas de frações polissacarídicas da Chlorophyta Caulerpa cupressoides var. flabellata
Polissacarídeos sulfatados de algas marinhas têm sido descritos por apresentarem diversas atividades farmacológicas. No entanto, nada se sabe a respeito da influência da salinidade da água do mar na estrutura de polissacarídeos sulfatados de algas verdes e nas atividades farmacológicas por eles desempenhadas. Por isso, objetivo principal deste trabalh
Publicado em: 2010
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18. Atividades biológicas de polissacarídeos sulfatados extraídos da alga vermelha gracilaria caudata
In recent years, sulfated polysaccharides (SP) from marine algae have emerged as an important class of natural biopolymers with potential pharmacology applications. Among these, SP isolated from the cell walls of red algae have been study due to their anticoagulant,antithrombotic and anti-inflammatory activities. In the present study, three sulfated polysacc
Publicado em: 2008
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19. Potencial terapêutico de um heparinóide isolado do invertebrado marinho Litopenaeus vannamei
The occurrence of bioactive compounds in marine organisms comes awaking the interest of the pharmaceutical industry. Heparin, a sulfated polysaccharide which presence was already identified in several marine invertebrates, is very attractive due its remarkable functional versatility. Besides to intervene in blood coagulation, this molecule has a great anti-i
Publicado em: 2008
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20. Caracterização parcial e atividades farmacológicas do extrato rico em polissacarídeos sulfatados da angiosperma marinha Halodule wrightii
Sulfated polysaccharides (PS) are biomolecules with a great biotechnological potential. There are few data about PS from high plants. In addition, pharmacological activities of PS from plants have not been carrying out. The aim of this work was extract PS from the angiosperm Halodule wrightii and study their anticoagulant and antioxidant activities. Histolog
Publicado em: 2008
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21. Efeito antitrombótico de uma fucana não anticoagulante extraída da alga Spatoglossum Schröederi
Fucan is a term used to denominate a family of sulfated L-fucose-rich polysaccharides. The brown alga Spatoglossum schröederi (Dictyotaceae) has three heterofucans namely fucan A, B and C. The 21 kDa fucan A is composed of a core of β (1-3) glucuronic acid-containing oligosaccharide of 4.5 kDa with branches at C4 of fucose chains α (1-3) linked. T
Publicado em: 2008
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22. Anticoagulant Activity of Sulfated galactans from red seaweeds of the genus Halymenia C. Agardh (Gigartinales, Rhodophyta) and its Effect Immunostimulant in marine shrimp Litopenaeus vannamei (Boone, 1931). / Atividade Anticoagulante de Galactanas Sulfatadas de Algas Marinhas Vermelhas do GÃnero Halymenia C. Agardh (Gigartinales, Rhodophyta) e seu Efeito Imunoestimulante no CamarÃo Marinho Litopenaeus vannamei (Boone, 1931)
Muitos compostos tÃm sido descritos como anticoagulantese imunoestimulantes, dentre essas os polissacarÃdeos sulfatados (PS) de algas marinhas que tambÃm sÃo conhecidos por apresentar outras atividades biolÃgicas, tais como antitrombÃtica e antiviral. A descoberta de novas drogas anticoagulantes à importante para prevenir os efeitos adversos do uso da
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/11/2006
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23. Efeitos de galactanas sulfatadas das algas marinhas Botryocladia occidentalis, Champia feldmannnii e Solieria filiformis no processo inflamatório agudo e na nocicepção. / Effects of sulfated galactans from marine algae Botryocladia occidentalis, Champa and Soli feldmannnii filiformis in acute inflammation and nociception.
The sulfated polysaccharides (SPL) constitutes a class of carbohydrates rich in polyanions and that presents a diversity of important biological activities. The antithrombotic and the anticoagulant activities are the most studied. It was demonstrated by the sulfated polysaccharides (SPL) the anti-inflammatory activity both in vitro and in vivo. However, the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/07/2006
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24. In vivo antithrombotic properties of a heparin from the oocyte test cells of the sea squirt Styela plicata(Chordata-Tunicata)
In the ascidian Styela plicata, the oocytes are surrounded by two types of accessory cells named follicle cells and test cells. A heparin-like substance with an anticoagulant activity equivalent to 10% of mammalian heparin and about 5% as potent as the mammalian counterpart for the inhibition of thrombin by antithrombin was isolated from the oocyte test cell
Brazilian Journal of Medical and Biological Research. Publicado em: 25/09/2006