Therapeutics
Mostrando 25-36 de 578 artigos, teses e dissertações.
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25. The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43
Abstract Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST
Acta Cir. Bras.. Publicado em: 13/12/2019
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26. Decompensated Heart Failure with Mid-Range Ejection Fraction: Epidemiology and In-Hospital Mortality Risk Factors
Abstract Background: Recently, a new HF entity, with LVEF between 40-49%, was presented to comprehend and seek better therapy for HF with preserved LVEF (HFpEF) and borderline, in the means that HF with reduced LVEF (HFrEF) already has well-defined therapy in the literature. Objective: To compare the clinical-therapeutic profile of patients with HF with mi
Int. J. Cardiovasc. Sci.. Publicado em: 24/10/2019
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27. Oficinas terapêuticas para cuidadores de idosos com demência – atuação da enfermagem no programa interdisciplinar de geriatria e gerontologia da UFF*
Resumo A demência provoca dependência e sofrimento para os idosos, cuidadores e familiares. Pensando nas necessidades desses cuidadores foi desenvolvido no “EPIGG/UFF” um grupo de suporte e orientação aos cuidadores de idosos com demência, que, através de oficinas, busca retirar dúvidas e informar sobre o cuidado. Assim, objetiva-se descrever algu
Rev. bras. geriatr. gerontol.. Publicado em: 24/10/2019
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28. The potential of plant and fungal proteins in the control of gastrointestinal nematodes from animals
Resumo A infecção por nematoides gastrintestinais é uma importante causa de grandes perdas econômicas na pecuária. O controle de nematoides com compostos químicos sintéticos é considerado insustentável devido ao aumento da resistência anti-helmíntica. Alternativas de controle, como o uso de produtos naturais, estão se tornando relevantes do ponto
Rev. Bras. Parasitol. Vet.. Publicado em: 04/07/2019
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29. Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide to
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 03/06/2019
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30. EVALUATION OF NEUROPATHIC PAIN SCALE KNOWLEDGE
RESUMO Objetivo: A dor neuropática (DN) é definida como “aquela decorrente de lesão ou doença que afeta diretamente o sistema somatossensitivo”, diferindo de outros tipos de dor em termos de sintomas, mecanismos e terapêutica, sendo o diagnóstico precoce pré-requisito para um manejo apropriado. As escalas de avaliação de dor são de grande util
Coluna/Columna. Publicado em: 01/06/2019
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31. Clinical Trials in Mitochondrial Disease: An Update on EPI-743 and RP103
Abstract Mitochondrial dysfunction results in the production of an abnormally high amount of reactive oxygen and nitrogen species, which results in redox imbalance and glutathione deficiency. Therapeutics such as EPI-743 (?-tocotrienol quinone) and RP103 (cysteamine bitartrate) have the theoretical potential to improve redox imbalance by increasing intracell
J. inborn errors metab. screen.. Publicado em: 16/05/2019
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32. Evaluation of the transcriptional immune biomarkers in peripheral blood from Warao indigenous associate with the infection by Mycobacterium tuberculosis
Abstract INTRODUCTION: Biomarkers are critical tools for finding new approaches for controlling the spread of tuberculosis (TB), including for predicting the development of TB therapeutics, vaccines, and diagnostic tools. METHODS: Expression of immune biomarkers was analyzed in peripheral blood cells stimulated and non-stimulated with M. tuberculosis ant
Rev. Soc. Bras. Med. Trop.. Publicado em: 16/05/2019
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33. ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients
Abstract INTRODUCTION: Candidiasis is the most frequent opportunistic mycosis in humans and can cause mortality, particularly in immunodeficient patients. One major concern is the increasing number of infections caused by drug-resistant Candidas trains, as these cannot be efficiently treated with standard therapeutics. The most common mechanism of fluconazo
Rev. Soc. Bras. Med. Trop.. Publicado em: 07/03/2019
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34. Doença do Enxerto-versus-hospedeiro ocular: Revisão
Resumo Doença do Enxerto-versus-hospedeiro (do inglês Graft-versus-Host Disease - GVHD) é uma complicação importante e com altas taxas de morbidade e mortalidade nos pacientes submetidos ao transplante alogênico de células-tronco hematopoiéticas. O acometimento ocular, denominado GVHD ocular, pode acometer todas as estruturas dos olhos, porém a unid
Rev. bras.oftalmol.. Publicado em: 2019-02
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35. Medication-related inpatient falls: a critical review
Abstract Falls are the second leading cause of accidental and unintentional injury deaths worldwide. Inpatient falls in hospital settings are likely to prolong the length of stay of patients in nearly 6.3 days, leading to increased hospitalization costs. The causes of fall incidents in healthcare facilities are multifactorial in nature and certain medication
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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36. Physical characterization of multiparticulate systems
ABSTRACT The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the ran
Braz. J. Pharm. Sci.. Publicado em: 07/05/2018