Therapeutics
Mostrando 13-24 de 578 artigos, teses e dissertações.
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13. Dramatic clinical response to dabrafenib plus trametinib in anaplastic thyroid carcinoma and the challenges faced during the COVID-19 pandemic
SUMMARY Anaplastic thyroid carcinoma is the rarest tumor of the thyroid gland, representing less than 2% of clinically recognized thyroid cancers. Typically, it has an extremely rapid onset, fatal outcomes in most cases, and a median overall survival of 3 to 10 months despite aggressive multidisciplinary management. The presence of targetable mutations in an
Arch. Endocrinol. Metab.. Publicado em: 2021-04
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14. Psychedelic drugs as new tools in psychiatric therapeutics
Resumo Introdução A prevalência de doenças da orelha média e seus fatores de risco já foram objeto de múltiplos estudos. A alta prevalência dessas doenças foi descrita entre os nativos da América do Norte, principalmente a otite média crônica. Tais estudos não foram feitos na América do Sul. Objetivo Descrever a prevalência de doenças da or
Braz. J. Psychiatry. Publicado em: 2021-04
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15. Update on human papilloma virus - part I: epidemiology, pathogenesis, and clinical spectrum,,
Abstract Infection with human papilloma virus (HPV) is related to a great number of cutaneous and mucosal manifestations. The spectrum of HPV ranges from inapparent infections, through various clinical benign presentations including cutaneous and mucosal disease, to malignant and premalignant conditions. New HPV types are currently described in the literatur
An. Bras. Dermatol.. Publicado em: 2021-02
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16. Complex Re-do robotic pyeloplasty using cryopreserved placental tissue: an adjunct for success
ABSTRACT Introduction and Objectives: Management of recurrent ureteropelvic junction obstruction (UPJO) following pyeloplasty presents a challenging clinical problem. Failure of initial pyeloplasty is, in part, secondary to ureteral devascularization and subsequent fibrosis. In this video, we present a case of an anastomotic augmentation with cryopreserved
Int. braz j urol.. Publicado em: 2021-02
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17. The Use of Exergames in the Neurorehabilitation of People with Parkinson Disease: The Impact on Daily Life
Abstract Introduction Parkinson disease (PD) is a progressive degeneration characterized by motor disorders, such as tremor, bradykinesia, stiffness and postural instability. Objective To evaluate the independence, confidence and balance in the development of daily activities in patients with PD before and after rehabilitation. Methods A descriptive, retr
Int. Arch. Otorhinolaryngol.. Publicado em: 2021-01
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18. Study of ongoing registered clinical trials on COVID-19: a narrative review
ABSTRACT BACKGROUND: The dangerous SARS-CoV-2 virus first emerged in China in December 2019 and has rapidly spread worldwide. Currently, it has affected more than 2,850,000 people. No vaccine or drug is available yet, and therefore researchers and scientists are striving to identify potential drugs or vaccines for combating this virus. We were unable to fi
Sao Paulo Med. J.. Publicado em: 2020-10
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19. An Approach to Technology Development and Current Medical Practice
Abstract Background An approach to technology development and the current medical practice. Objective To consider the many stages of medical-applied technological developments and its main consequences related to the current medical practice and speculate on future developments. Methods Assessment of historical publications and individual and metanalys
Int. J. Cardiovasc. Sci.. Publicado em: 2020-10
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20. Diabetes Mellitus, Insulin Use, and Infective Endocarditis
Abstract Background: Recently, a new HF entity, with LVEF between 40-49%, was presented to comprehend and seek better therapy for HF with preserved LVEF (HFpEF) and borderline, in the means that HF with reduced LVEF (HFrEF) already has well-defined therapy in the literature. Objective: To compare the clinical-therapeutic profile of patients with HF with mi
Int. J. Cardiovasc. Sci.. Publicado em: 2020-02
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21. Decompensated Heart Failure with Mid-Range Ejection Fraction: Epidemiology and In-Hospital Mortality Risk Factors
Abstract Background: Recently, a new HF entity, with LVEF between 40-49%, was presented to comprehend and seek better therapy for HF with preserved LVEF (HFpEF) and borderline, in the means that HF with reduced LVEF (HFrEF) already has well-defined therapy in the literature. Objective: To compare the clinical-therapeutic profile of patients with HF with mi
Int. J. Cardiovasc. Sci.. Publicado em: 2020-02
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22. Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy
Abstract Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration compromised the field of its advancement. Single chai
Genet. Mol. Biol.. Publicado em: 17/01/2020
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23. In Silico Target Identification and Validation for Antioxidant and Anti-inflammatory Activity of Selective Phytochemicals.
Abstract Phytochemicals present in plant extract include a number of biological active compounds which have shown promising antioxidant and anti-inflammatory activities in many animal studies. Present knowledge about the biochemical interactions of these compounds present in phytochemical extracts and target enzymes or proteins responsible for antioxidant an
Braz. arch. biol. technol.. Publicado em: 20/12/2019
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24. Inflexões epistemológicas: a Etnopsiquiatria
Resumo A Etnopsiquiatria, fundada por Geroges Devereux, surge enquanto possibilidade de refletir o encontro intercultural e seus desdobramentos quanto à compreensão do adoecimento psíquico e à coerência entre terapêuticas e etiologias deste adoecimento. A síntese teórica que levou à criação da disciplina emerge de inflexões baseadas principalment
Fractal, Rev. Psicol.. Publicado em: 20/12/2019