Therapeutic Cloning
Mostrando 1-12 de 69 artigos, teses e dissertações.
-
1. Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine era
Abstract Germline mutations in BRCA1 and BRCA2 (BRCA) genes confer high risk of developing cancer, especially breast and ovarian tumors. Since the cloning of these tumor suppressor genes over two decades ago, a significant amount of research has been done. Most recently, monoallelic loss-of-function mutations in PALB2 have also been shown to increase the ris
Genet. Mol. Biol.. Publicado em: 29/04/2019
-
2. Genetic engineering of Theileria parva lactate dehydrogenase gene: a new anti-theilerial target
ABSTRACT: Theileria parva is the causative agent of East Coast Fever (ECF), a tick borne disease, which results in major economic losses in cattle. Major problems in dealing with this illness are the high cost of drugs, development of resistance, and absence of effective vaccines. Thus, exploiting new targets for cost effective and higher therapeutic value d
Pesq. Vet. Bras.. Publicado em: 2018-05
-
3. Produção e caracterização da porção Fab do anticorpo anti-digoxina utilizando a tecnologia de phage display. / Production and characterization of the Fab portion of anti-digoxin antibody by phage display technology.
Digoxin is a pharmaceutical used in the control of cardiac dysfunction. Its therapeutic window is very narrow. To counteract the toxic effect, polyclonal anti-digoxin Fab fragments are commercially available. Our goal was to obtain variants of monoclonal anti-digoxin Fab fragments by phage display technology, which allows the generation of high affinity and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/03/2012
-
4. Análise do transcriptoma da glândula produtora de veneno de Loxosceles intermedia (aranhamarrom): perfil de expressão e identificação de novas toxinas. / Effects of metalloproteinas from Brotrops leucurus venon and brown spiders venoms on endothelial cell and components of extracellular matrix.
Loxosceles genus spiders are responsible for accidents all over the world and have clinical importance in the South of Brazil. The venom of these spiders is made up of several toxins, including proteins, which are responsible for the clinical pattern called loxoscelism. To describe the transcriptional profile of the L. intermedia venom gland, we generated a
Publicado em: 2010
-
5. Cloning, expression and characterisation of an HtrA-like serine protease produced in vivo by Mycobacterium leprae
Members of the high temperature requirement A (HtrA) family of chaperone proteases have been shown to play a role in bacterial pathogenesis. In a recent report, we demonstrated that the gene ML0176, which codes for a predicted HtrA-like protease, a gene conserved in other species of mycobacteria, is transcribed by Mycobacterium leprae in human leprosy lesion
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
-
6. Stem cell grafts as therapeutic tools for central nervous system disorders
The last few years have seen a growing interest in stem cell research. The media has helped to keep attention to the subject making it as popular as therapeutic cloning. A number of studies highlighted the importance of stem cells as prospective therapy for neurodegenerative conditions. The possibility of successful treatment for such pathologies using stem
Psychology & Neuroscience. Publicado em: 2008-06
-
7. Limitações jurídicas às pesquisas em células-tronco embrionárias.
The objective of this dissertation is to examine some of the legal implications of the biotechnological revolution as well as its reflexes on the body of legal knowledge as a hole specially in what concerns embryonic stem cells for therapeutic use abiding by Brazilian Federal Statue 11.105/2005. The paper alerts to the relevance of preserving such research w
Publicado em: 2008
-
8. Human cloning and personality rights / Clonagem humana e direitos da personalidade
The scientific advancement of biotechnology, particularly the development of human cloning techniques, has made urgent and crucial the analysis of its ethical and legal implications. The present study aims to investigate emerging questions concerning both therapeutic and reproductive techniques of human cloning in the light of personality rights. In addition
Publicado em: 2006
-
9. A Influência religiosa nas proposicões legislativas no Congresso Nacional : clonagem terapêutica como estudo de caso
INTRODUCTION: Even though the Brazilian Constitution defines the nation as a laic State, a great difficulty has been observed in the transition from the confessional State, following up to the XIX Century, to the public secularity presently required. OBJECTIVE: To study the religious implications related to the Constitutional Amendment Bills (PEC) and the Le
Publicado em: 2006
-
10. Impactos do princípio da dignidade humana no direito a vida do embrião
The theme of this M.A. dissertation is the analysis of the impact of the principle of dignity of human beings regarding the right to life of embryos, in face of new scientific techniques in the field of biomedicine. Initially, the approach is on ethical aspects of bioethics and its importance to the bio-law, highlighting the need of specific and comprehensiv
Publicado em: 2006
-
11. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
The modern approach to the development of new chemical entities against complex diseases, especially the neglected endemic diseases such as tuberculosis and malaria, is based on the use of defined molecular targets. Among the advantages, this approach allows (i) the search and identification of lead compounds with defined molecular mechanisms against a defin
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-10
-
12. Embriões, células-tronco e terapias celulares: questões filosóficas e antropológicas
AS THE possibility of therapeutic cloning in humans has just been demonstrated by a Corean group of researchers, the paper argues that biotechnologies of that kind may contribute to alleviate the chronic shortage of organs and tissues for transplantation. Ever since immunosuppressant drugs have become available, transplantation surgery has made considerable
Estudos Avançados. Publicado em: 2004-08