Teratogenic
Mostrando 25-36 de 108 artigos, teses e dissertações.
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25. Evaluation of the teratogenic risks em gestations exposed to misoprostol: a case-control study / Avaliação de Riscos Teratogênicos em Gestações Expostas ao Misoprostol: Um estudo de caso-controle
INTRODUÇÃO: O misoprostol (Cytotec) é um análogo de prostaglandina E1, inicialmente comercializado com finalidades terapêuticas do trato gastrintestinal, de uso proscrito em gestantes pelo risco de abortamento. A realidade do aborto e o ineficiente controle de medicamentos em nosso país tornaram generalizado seu uso como método abortivo. Estudos demon
Publicado em: 2006
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26. Adriamycin-induced fetal hydronephrosis
INTRODUCTION: At the end of pregnancy, the amniotic fluid (AF) depends basically on renal function, corresponding to fetal urine. Changes in AF, especially oligohydramnios, are reported in association with fetal hydronephrosis (FH). The experimental model using adriamycin in pregnant female rats has a teratogenic effect and has been classically employed to s
International braz j urol. Publicado em: 2004-12
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27. Efeitos da ingestão do alcool durante a gestação na imunoexpressão do EGF na amelogenese e dentinogenese do 1º molar inferior de ratos
Previous studies have reported that the maternal exposure to alcohol reduces the maxilo-fadal development, including a delay in the formation and eruption of the tooth, as well as, enamel anomalies. The mechanisms of these deleterious effects are not fully clarified. The objective of this study was to analyze using polyclonal antibody of the Epidermal Growth
Publicado em: 2004
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28. Desenvolvimento de metodos analiticos para determinação de nitrato, nitrito e n-nitrosaminas em produtos carneos
Nitrosamines are N-nitroso compounds formed in certain foods by the reaction of a nitrosating agent, derived from either nitrite salts or nitrogen oxide, with a substance having an amino group. The majority of nitrosamines tested in animals are carcinogenic, mutagenic, teratogenic and act transplacentally. This work describes analytical methods for the deter
Publicado em: 2004
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29. Níveis de ocorrência de Hg total em peixes carnívoros das represas de Barra Bonita e Bariri, em função da variação de parâmetros biológicos e da presença de selênio.
The Barra Bonita and Bariri reservoirs, Medium river Tietê, São Paulo, Brazil, are used with several purposes as transport, provisioning, electric power generation, professional fishery and leisure. The region is surrounded by an industrial developed pole, receiving sewer of domestic and industrial origin, as well as the effluents of agricultural activitie
Publicado em: 2004
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30. Efeito de bloqueadores de canais de íons cálcio sobre espermatozóides e oócitos de hamsters fecundados in vivo e in vitro / Effects of calcium ion channel blockers on hamster spermatozoa and oocytes in in vivo and in vitro fertilization
Fertilization process is closely related with calcium ion. There are reports about voltage-dependent calcium ion channel blockers of anti-hypertension therapeutic use causing male infertility, but there are few reports about such effects on the oocyte. The main goal of this experiment was to check the influence of verapamil, nifedipine and diltiazem (L-type
Publicado em: 2004
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31. Estudo de variabilidade genÃtica de aspergillus flavus como base para o desenvolvimento de PCR multiplex para detecÃÃo de fungos produtores de aflatoxinas em castanha-do-brasil e bastanha de caju
Aflatoxins represent a group of similar heterocyclic and highly oxygenated substances, which are toxic to man and animals. Products of secondary metabolism in the filamentous fungi Aspergillus flavus, A. parasiticus, A. pseudotamarii and A. nomius, the species A. flavus and A. parasiticus are of greatest economic importance. The most important aflatoxins are
Publicado em: 2004
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32. Adverse pregnancy outcome in rats following exposure to a Salacia reticulata (Celastraceae) root extract
The root extract of Salacia reticulata Wight (family: Celastraceae) is used in Sri Lanka by traditional practitioners as a herbal therapy for glycemic control even during pregnancy. It is recognized that some clinically used antidiabetic drugs have harmful effects on pregnancy but the effects of the S. reticulata root extract on reproductive outcome is unkno
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-07
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33. O renascimento de um fármaco: talidomida
Thalidomide, first synthesized in 1953, was widely prescribed for morning sickness of pregnant women from 1957 to 1961, when it was found to be seriously teratogenic, having caused serious birth defect. Nowadays, a quarter of a century later, it appears that it may be a miracle drug for such diseases as leprosy, AIDS, cancer and tuberculosis.
Química Nova. Publicado em: 2001-10
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34. The genetic study of sterigmatocystin production in Aspergillus nidulans. / Estudo genético da produção de esterigmatocistina em Apergillus nidulans.
Sterigmatocystin (ST) is a polyketide produced by different species of Aspergillus as well as by other fungus genera such as Bipolaris and Chaetomium. This toxin is characterized as a bifuranoxanthone, whose molecular formula is C18H12O6 and which is frequently found as a contaminant in several food products such as oil-seed grains and cereals. It has carcin
Publicado em: 1999
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35. Medical genetics: 1. Clinical teratology in the age of genomics
Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogenesis, as well as known genetic susceptibilities to teratogen
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36. Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents.
We have tested 74 teratogenic and 28 nonteratogenic agents in a recently developed in vitro teratogen assay system. The assay identifies teratogens by their ability to inhibit attachment of ascites tumor cells to plastic surfaces coated with concanavalin A. There is a qualitative agreement between in vivo animal data and in vitro activity for 81 of the 102 a