Telomere
Mostrando 25-36 de 907 artigos, teses e dissertações.
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25. Similarity between the association factor of ribosomal subunits and the protein Stm1p from Saccharomyces cerevisiae
A ribosome association factor (AF) was isolated from the yeast Sacchharomyces cerevisiae. Partial amino acid sequence of AF was determined from its fragment of 25 kDa isolated by treating AF with 2-(2-nitrophenylsulfenyl)-3-methyl-3'-Bromoindolenine (BNPS-skatole). This sequence has a 86% identity to the product of the single-copy S. cerevisiae STM1 gene tha
Memórias do Instituto Oswaldo Cruz. Publicado em: 2004-11
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26. Organização genomica das sequencias subtelomericas (TAS - "Telomere associated sequences") de Leishmania (Leishmania) amazonensis e identificação de proteinas que reconhecem especificamente estas sequencias
Os telômeros são complexos de DNA e proteínas que protegem os cromossomos eucarióticos da degradação e fusão terminais, garantindo a estabilidade genômica. As seqüências teloméricas são ricas em guaninas e na maioria dos eucariotos terminam em uma protrusão 3 simples fita denominada de "3 G-overhang". As seqüências adjacentes aos telômeros co
Publicado em: 2004
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27. Charaterization of Leishmania major Friedlin Telomeric Terminus
Here we have characterized Leishmania major (Friedlin) telomeric terminus (the very end) using recombinants obtained by a vector-adaptor cloning protocol. As in L. donovani, the last nine nucleotides of L. major terminus are 5'-GGTTAGGGT-OH 3', differing from Trypanosoma cruzi and T. brucei terminus 5'GGGTTAGGG-OH 3', thus indicating that these sequences are
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-04
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28. Associações telomericas como indicadores de instabilidade cromossomica em pacientes com leucemias mieloides e sindromes mielodisplasicas
The associations between specific chromosomal abnormalities and different types of hematological neoplasias are well established. However, telomeric associations (tas), which are associations between termini regions of chromosomes (telomeres), are sporadicly observed in neoplasias, leading to the question about their role as a biological indicator of occupat
Publicado em: 1999
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29. Involvement of Replicative Polymerases, Tel1p, Mec1p, Cdc13p, and the Ku Complex in Telomere-Telomere Recombination
Telomere maintenance is required for chromosome stability, and telomeres are typically replicated by the action of the reverse transcriptase telomerase. In both tumor and yeast cells that lack telomerase, telomeres are maintained by an alternative recombination mechanism. Genetic studies have led to the identification of DNA polymerases, cell cycle checkpoin
American Society for Microbiology.
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30. Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability.
Telomeres are required for the stable maintenance of chromosomes in the yeast Saccharomyces cerevisiae. Telomeres also repress the expression of genes in their vicinity, a phenomenon known as telomere position effect. In an attempt to construct a conditional telomere, an inducible promoter was introduced adjacent to a single telomere of a chromosome such tha
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31. Telomere length regulation in mice is linked to a novel chromosome locus
Little is known about the mechanisms that regulate species-specific telomere length, particularly in mammalian species. The genetic regulation of telomere length was therefore investigated by using two inter-fertile species of mice, which differ in their telomere length. Mus musculus (telomere length >25 kb) and Mus spretus (telomere length 5–15 kb) were u
The National Academy of Sciences.
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32. Insertion of a Telomere Repeat Sequence into a Mammalian Gene Causes Chromosome Instability
Telomere repeat sequences cap the ends of eucaryotic chromosomes and help stabilize them. At interstitial sites, however, they may destabilize chromosomes, as suggested by cytogenetic studies in mammalian cells that correlate interstitial telomere sequence with sites of spontaneous and radiation-induced chromosome rearrangements. In no instance is the length
American Society for Microbiology.
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33. Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer
The Schizosaccharomyces pombe Ku70–Ku80 heterodimer is required for telomere length regulation. Lack of pku70+ results in telomere shortening and striking rearrangements of telomere-associated sequences. We found that the rearrangements of telomere-associated sequences in pku80+ mutants are Rhp51 dependent, but not Rad50 dependent. Rhp51 bound to telomere
Oxford University Press.
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34. Rap1p telomere association is not required for mitotic stability of a C3TA2 telomere in yeast
Telomeric DNA usually consists of a repetitive sequence: C1–3A/TG1–3 in yeast, and C3TA2/T2AG3 in vertebrates. In yeast, the sequence-specific DNA- binding protein Rap1p is thought to be essential for telomere function. In a tlc1h mutant, the templating region of the telomerase RNA gene is altered so that telomerase adds the vertebrate telomere sequence
Oxford University Press.
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35. Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans
Terminal restriction fragment analysis is the only method currently available for measuring telomere length in Caenorhabditis elegans. Its limitations include low sensitivity and interference by the presence of interstitial telomeric sequences in the C.elegans genome. Here we report the adaptation of single telomere length analysis (STELA) to measure the len
Oxford University Press.
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36. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these telomeres suggests that recognition of chromosome ends might contribute to the epigenetic protection of telomeres. In mammals, Ataxia Telangiectasia Mutated (ATM) is
Cold Spring Harbor Laboratory Press.