Telomere
Mostrando 13-24 de 907 artigos, teses e dissertações.
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13. Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease
Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of
Rev. Bras. Psiquiatr.. Publicado em: 17/10/2016
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14. Cytogenetics and sperm ultrastructure of Atelopus spumarius (Anura, Bufonidae) from the Brazilian Amazon
The current taxonomy of most Atelopus species is based on morphological and color data only. Recent studies suggest that A. spumarius may represent a species complex assigned under the same name. Karyotypic data and description of sperm ultrastructure for 13 specimens of A. spumarius are presented here for the first time. A chromosomal analysis revealed 2n =
Genet. Mol. Biol.. Publicado em: 03/09/2013
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15. Diversidade genética de isolados do fungo Sporisorium scitamineum analisada através de fingerprinting da região telomérica / Genetic diversity of isolates of the fungus Sporisorium scitamineum analyzed by fingerprinting the telomeric region
The genetic diversity of Sporisorium scitamineum, the sugarcane smut agent, was characterized in a 14 isolates collection. The isolates were obtained from various sugarcane growing areas and RFLP of the telomeric region was used as molecular marker, compared with AFLP. Teliospores were collected from the whip of infected plants. Teliospores are diploids and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/09/2012
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16. Testosterone therapy delays cardiomyocyte aging via an androgen receptor-independent pathway
The testicular feminized (Tfm) mouse carries a nonfunctional androgen receptor (AR) and reduced circulating testosterone levels. We used Tfm and castrated mice to determine whether testosterone modulates markers of aging in cardiomyocytes via its classic AR-dependent pathway or conversion to estradiol. Male littermates and Tfm mice were divided into 6 experi
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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17. Chromosomal localization of the 18S-28S and 5S rRNA genes and (TTAGGG)n sequences of butterfly lizards (Leiolepis belliana belliana and Leiolepis boehmei, Agamidae, Squamata)
Chromosomal mapping of the butterfly lizards Leiolepis belliana belliana and L. boehmei was done using the 18S-28S and 5S rRNA genes and telomeric (TTAGGG)n sequences. The karyotype of L. b. belliana was 2n = 36, whereas that of L. boehmei was 2n = 34. The 18S-28S rRNA genes were located at the secondary constriction of the long arm of chromosome 1, while th
Genetics and Molecular Biology. Publicado em: 26/08/2011
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18. Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population
Alpha-thalassemia is the most common inherited disorder of hemoglobin synthesis. Genomic deletions involving the alpha-globin gene cluster on chromosome 16p13.3 are the most frequent molecular causes of the disease. Although common deletions can be detected by a single multiplex gap-PCR, the rare and novel deletions depend on more laborious techniques for th
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-01
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19. Telomere length measurements on Human T-cell leukemia virus type I (HTLV-I) infected cells using fluorescence in situ hybridization and flow cytometry (Flow-FISH) / Avaliação do comprimento dos telômeros em células infectadas pelo vírus HTLV-I utilizando a técnica hibridização in situ fluorescente e citometria de fluxo (Flow-FISH)
INTRODUCTION: Adult T-cell Leukemia/Lymphoma (ATL) is a chronic lymphproliferative disease with clonal transformation predominantly of the TCD4+ lymphocytes, caused by the Human T lymphotropic virus type-I (HTLV-I). ATL develops itself in 3-5% of HTLV-I carriers after a long period of clinical latency accompanied by clonal expansion of the infected lymphocyt
Publicado em: 2008
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20. Cytogenetic markers as diagnoses in the identification of the hybrid between Piauçu (Leporinus macrocephalus) and Piapara (Leporinus elongatus)
The genetic monitoring of interspecific hybrids involves the application of methodologies able to provide an easy and indubitable genetic characterization of both parental and hybrid individuals. In the present work, cytogenetic techniques were used to identify a hybrid lineage of "Piaupara" in order to caracterize them in relation to the parental species, L
Genetics and Molecular Biology. Publicado em: 2008
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21. Karyotypic differentiation through chromosome fusion and number reduction in Imparfinis hollandi (Ostariophysi, Heptapteridae)
The Neotropical Heptapteridae fish Imparfinis hollandi, endemic to the Iguaçu River Basin (Brazil), was cytogenetically analyzed and the diploid chromosome number of 2n = 42 chromosomes was determined (22m + 10sm + 10st), the lowest diploid number in this genus and family. Like other Heptapteridae species, only one NOR-bearing chromosome pair was detected b
Genetics and Molecular Biology. Publicado em: 2008
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22. Estudo dos telômeros em tecido hipocampal de camundongos submetidos a um estresse psicossocial prolongado / Study on telomere biology of hippocampal tissue of mice submitted to a long term psychosocial stress
O estresse é muito presente na vida das pessoas, e grande parte deste é de origem social. O estresse contínuo induz a uma série de efeitos nocivos no organismo. Estes efeitos também podem ser observados no cérebro, principalmente no hipocampo, onde promove alterações na sua morfologia e função. Recentemente, demonstrou-se uma redução do tamanho d
Publicado em: 2008
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23. DNA repetitivo e seu papel na estrutura cromossômica terminal em Rhynchosciara americana (Diptera: Sciaridae) / The role of repetitive DNA in the chromosome termini of Rhynchosciara americana (Diptera: Sciaridae)
The chromosomal localization of ribosomal DNA (rDNA) was studied in polytene and diploid tissues of four sciarid species, Trichosia pubescens, Rhynchosciara americana, R. milleri and Schwenkfeldina sp. While hybridization to mitotic chromosomes showed the existence of a single rDNA locus, ribosomal probes hybridized to more than one polytene chromosome regio
Publicado em: 2008
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24. Averiguação da localização sub-telomérica dos genes do antígeno B de Echinococcus
A forma larval de Echinococcus granulosus (metacestóide) é o agente causador da hidatidose cística, zoonose endêmica no Rio Grande do Sul. Essa parasitose caracteriza-se pelo crescimento de uma massa cística preenchida de líquido hidático que causa compressão em órgãos e tecidos vizinhos. O antígeno B (AgB) é um dos maiores componentes do líquid
Publicado em: 2007