Sesquiterpene Lactone
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. Development and validation of a stability indicating method for quantification of the sesquiterpene lactone eremantholide C from Lychnophora trichocarpha (Brazilian arnica)
ABSTRACT Pharmacological activities as anti-inflammatory, anti-hyperuricemic, anti-gouty arthritis, antitumor and trypanocidal activities of the aerial parts from Lychnophora trichocarpha (Spreng.) Spreng. ex Sch.Bip., Asteraceae (Brazilian arnica) have already been proved. Eremantholide C is a sesquiterpene lactone and one of the active chemical constituent
Rev. bras. farmacogn.. Publicado em: 2017-08
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2. A New Furanoheliangolide Sesquiterpene Lactone from Calea pinnatifida (R. Br.) Less. (Asteraceae) and Evaluation of Its Trypanocidal and Leishmanicidal Activities
Calea pinnatifida (R. Br.) Less. is commonly known in Brazil as "cipó-cruz", "quebra-tudo" or "aruca". This species is employed in folk medicine as giardicidal, amoebicidal and to treat digestive disorders. The present paper describes the isolation and structure determination of a new furanoheliangolide sesquiterpene lactone named 11,13-dihydroxy-calaxin, i
J. Braz. Chem. Soc.. Publicado em: 2017-02
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3. Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils
Abstract The tagitinins isolated of Tithonia diversifolia (Hemsl.) A. Gray, Asteraceae, are the most studied sesquiterpene lactones due to their wide spectrum of pharmacologic activities, especially related with nuclear factor-kappa B inhibition. Nevertheless, detailed studies about the mechanism of action of its active compounds are still lacking. Neutrophi
Rev. bras. farmacogn.. Publicado em: 2015-04
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4. Topical anti-inflammatory activity of yacon leaf extracts
Smallanthus sonchifolius (Poepp.) H. Rob. , Asteraceae, known as yacon, is an herb that is traditionally used for the treatment of diabetes in folk medicine. However, recent studies have demonstrated that this plant has other interesting properties such as anti-microbial and anti-inflammatory actions. Thus, the purpose of this study was to evaluate the topic
Rev. bras. farmacogn.. Publicado em: 10/05/2013
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5. Seasonal variation of the major secondary metabolites present in the extract of Eremanthus mattogrossensis Less (Asteraceae: Vernonieae) leaves
The species Eremanthus mattogrossensis, known as "veludo do cerrado" (cerrado velvet), is native to the Brazilian Cerrado. Because the amount of metabolites present in plants may be influenced by biological and environmental factors, here we conducted an HPLC-DAD-MS/MS investigation of the metabolite concentrations found in the MeOH/H2O extract of the leaves
Quím. Nova. Publicado em: 2012
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6. Transformações microbianas da lactona sesquiterpênica tagitinina C / Microbial transformation of sesquiterpene lactone tagitinin C
A busca por moléculas de origem natural que ocupem um espaço químico diferente daquelas já existentes tornou-se uma necessidade para atender às novas demandas das indústrias farmacêuticas. A pesquisa envolvendo transformações microbianas de metabólitos secundários de origem vegetal pode ser utilizada como uma nova ferramenta na biosíntese destas
Publicado em: 2009
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7. Atribuição Inequívoca dos Sinais de RMN de 1H e de 13C do Glaucolídeo B, Síntese de seus Derivados e Síntese de 2-Fenil-6,7-exo-Isopropilidenodioxi- 8-Oxabiciclo-[3.2.1]-Oct-2-eno, Visando a Obtenção de Novos Herbicidas
Considering the increasing need of new chemical products for the rational and efficient weeds control, it was conducted a research of new compounds provided with herbicide activity, as well as the study for unequivocal determination of Glaucolide B [1], structure a sesquiterpene lactone containing a cycle of ten members. For this, the Glaucolide B was isolat
Publicado em: 2008
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8. Avaliação in vitro do mecanismo de ação citotóxica de lactonas sesquiterpênicas e outras substâncias isoladas de Vernonia scorpioides (LAM) PERS / In vitro evaluation of the cytotoxicity mechanism of sesquiterpene lactones and other substances isolated from Vernonia scorpioides (LAM) PERS
The development of new drugs is of utmost importance for the treatment of cancer. Vernonia scorpioides presents antiinflammatory and antitumoral effects. In this study, the investigation of Vernonia scorpioides afforded the hirsutinolide isolate, a mixture of sesquiterpene lactones and an unpublished polyacetylene. We report on the cytotoxic activity and the
Publicado em: 2007
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9. Composição química e atividades biológicas das folhas de Cynara scolymus L. (alcachofra) cultivada no Brasil
The present paper describes the chemical composition and biological activities of artichoke cultivated in Brazil. Our studies demonstrated that glycosyl flavonoids (cynaroside and scolymoside), are the major constituents, along with cynaropicrin, a sesquiterpene lactone, and the triterpene lupeol. Cynarin, which is the main compound described for artichoke,
Química Nova. Publicado em: 2003-05
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10. Dosagem de artemisinina em Artemisia annua L. por cromatografia líquida de alta eficiência com detecção por índice de refração
Artemisinin is a sesquiterpene lactone used in treatment of chloroquine-resistant malaria. This paper presents high-performance liquid chromatographic assay for artemisinin in leaves of A. annua using differential refractometer detector and a single step of clean-up in a silica cartridge. The average of recoveries were 95% and the limit of quantification was
Revista Brasileira de Farmacognosia. Publicado em: 2002
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11. Estudos visando a sÃntese de 7-hidroxi-6,11-ciclofarnes-3(15)-EN-2-ONA
In this work we describe alternative synthetic routes toward the preparation of a new α,β-unsaturated sesquiterpene with antibacterial activity isolated from Premma oligotricha. Baeyer-Villiger oxidation of trimethyldecalone (51a) yielded the corresponding lactone intermediate (52a) which was submitted to several sulfophenyl- and hydroxymethylation
Publicado em: 2002
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12. Terpenos de Wunderlichia crulsiana e Mikania sp. nov. / Terpenes from Wunderlichia crulsiana and Mikania sp. nov.
This work describes the chemical study of two plants which belong to the family Asteraceae: Mikania sp. nov. and Wunderlichia crulsiana. The dichlorometane extracts from leaves and stems of Mikania sp. nov. we studied and seven diterpenic acids were isolated and identified. The volatile oil from leaves and stems of this plant were also studied and twenty sub
Publicado em: 2000