Post Transcriptional Regulation
Mostrando 1-12 de 317 artigos, teses e dissertações.
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1. In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis
Abstract Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation of targets by cleavage or degradation of the mRNA. Fungi of the Paracoccidioides complex are the etiological agents of the main systemic mycosis of Latin America. These fungi present a plasticity to adapt and survive in
Genet. Mol. Biol.. Publicado em: 14/02/2019
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2. MicroRNAs: new biomarkers and promising therapeutic targets for diabetic kidney disease
Resumo A doença renal do diabetes (DRD) é uma complicação crônica do diabetes mellitus associada à elevada morbidade e mortalidade, considerada um problema de saúde mundial. Dentre os fatores associados ao desenvolvimento e à progressão da DRD, destacam-se os microRNAs, que consistem em pequenas moléculas de RNA que regulam a expressão gênica por
J. Bras. Nefrol.. Publicado em: 07/02/2019
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3. RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae
Abstract RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein compl
Genet. Mol. Biol.. Publicado em: 2017-03
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4. O papel dos microRNAs de células T na susceptibilidade/resistência a artrite reumatóide experimental / The role of T lymphocytes microRNAs in the resistance/susceptibility to the experimental arthritis.
MicroRNAs (miRNAs) are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. During the last several years, evidence has emerged to show their critical role for the regulation and development of immune system. Although the function of most mammalian miRNAs has yet to be determined, t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/03/2012
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5. The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis
Trypanosomes are parasitic protozoa in which gene expression is primarily controlled through the regulation of mRNA stability and translation. This post-transcriptional control is mediated by various families of RNA-binding proteins, including those with zinc finger CCCH motifs. CCCH zinc finger proteins have been shown to be essential to differentiation eve
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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6. The miR-17-92 cluster regulates FOG-2 expression and inhibits proliferation of mouse embryonic cardiomyocytes
MicroRNAs (miRNAs) have gradually been recognized as regulators of embryonic development; however, relatively few miRNAs have been identified that regulate cardiac development. A series of recent papers have established an essential role for the miRNA-17-92 (miR-17-92) cluster of miRNAs in the development of the heart. Previous research has shown that the Fr
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
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7. Influência do Gene pacC na Regulação de Manosiltransferases no Dermatófito Trichophyton rubrum em Função de Variações Nutricionais e pH Ambiente. / Influence of Gene pacC in Mannosiltransferase Regulation of the Dermathophyte Trichophyton rubrum in Function to Changes by pH and Nutrient Sources.
Gene expression regulation is essential for fungi to adapt to environmental adversities, such as changes in the extracellular pH, nutrient starvation, ionic strength, and temperature. The adaptive response to ambient pH is well characterized in model fungi such as Aspergillus nidulans, and involves the signal transduction pathway consisting of the products o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/12/2011
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8. Avaliação da expressão e localização da conexina 43 na injúria isquêmica renal aguda / Evaluation of Connexin 43 expression and localization in renal acute ischemic injury
The cells require contact with other cells and the extracellular matrix for tissue formation. Gap junctions are narrow channels connecting the cytoplasm of two adjacent cells, promoting the passage of inorganic ions, amino acids, nucleotides and other metabolites. These junctions are composed of two conexons or hemichannels, crossing the cell plasma membrane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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9. Non genomic actions of triiodothyronine (T3) on the expression polyadenylation and distribution of TSH granules in thyrotrophs of hypothyroid rats / Ações não genômicas da triiodotironina (T3) sobre a expressão, poliadenilação e distribuição dos grânulos de TSH nos tireotrofos de ratos hipotireiodeos
The thyroid-stimulating hormone (TSH) is the main regulator of the synthesis and secretion of thyroid hormones (TH), which exert a negative feedback mechanism in the pituitary by reducing the synthesis of β and α (CGA - Glycoprotein hormones alpha chain) chains through mechanisms that involve changes in the tra
Publicado em: 2010
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10. Proteínas quinases envolvidas na regulação do estresse em Trypanosoma. / Protein kinases involved in stress regulation in Trypanosoma.
Protozoa of the genus Trypanosoma have a complex life cycle alternating between vertebrate and invertebrate hosts. The adaptation to different environmental conditions requires rapid changes in gene expression to fill up the morphological and metabolic requirements for survival. Very little is known about the mechanisms that control these changes and the sig
Publicado em: 2010
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11. Dengue virus-induced regulation of the host cell translational machinery
Dengue virus (DV)-induced changes in the host cell protein synthesis machinery are not well understood. We investigated the transcriptional changes related to initiation of protein synthesis. The human hepatoma cell line, HepG2, was infected with DV serotype 2 for 1 h at a multiplicity of infection of one. RNA was extracted after 6, 24 and 48 h. Microarray r
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-11
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12. Expressão gênica e protéica de rodopsina em células pigmentares e mecanismos de sinalização intracelular da sua modulação por endotelinas / Modulation of rhodopsin expression and signaling mechanisms evoked by endothelins in in pigment cell lines
Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of vasoconstrictor peptides, which can regulate pigment migration and/or production in vertebrate pigment cells (chromatophores). In teleostean fish, ETs/SRTXs induce pigment migration. In human melanocytes, ETs promote melanogenesis and mitogenesis. ETs also regulate the transcription of several
Publicado em: 2009