Plga
Mostrando 13-24 de 134 artigos, teses e dissertações.
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13. Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles
The aim of this study was to develop and characterize poly-ε-caprolactone (PCL) and poly(D,L-lactic-co-glycolic)-acid (PLGA) microparticles containing coencapsulated trans-dehydrocrotonin (t-DCTN) and t-DCTN:hydroxypropyl-β-cyclodextrin inclusion complex (t-DCTN:HP-β-CD), with t-DCTN loaded at concentrations ranging from 11.25 to 45.00 mg. A preformulatio
J. Braz. Chem. Soc.. Publicado em: 2017-08
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14. Evaluation of polymeric PLGA nanoparticles conjugated to curcumin for use in aPDT
ABSTRACT Antimicrobial photodynamic therapy (aPDT) involves the association of a photosensitizing agent with a light source with the goal of causing apoptosis or microbial lysing. The use of compounds with natural active principles is gaining prominence throughout the world. Several studies from groups that are linked to the development of innovations in the
Braz. J. Pharm. Sci.. Publicado em: 20/07/2017
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15. Ameliorating the antitumor activity of lenalidomide using PLGA nanoparticles for the treatment of multiple myeloma
Abstract Lenalidomide (LND) is an anti-cancer drug and an effective derivative of thalidomide used for multiple myeloma therapy. Because of its poor solubility in water, LND is known to cause low oral bioavailability (below 33%), and as a direct consequence of this, the dosing frequency is extended thus increasing risk of toxicity. To improve its bioavailabi
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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16. A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles
ABSTRACT The development and validation of a simple and efficient method for the quantification of ferulic acid in poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan (CS) by reverse phase high performance liquid chromatography coupled to photodiode array detection was described. For the chromatographic analysis, a reverse phase C-18 co
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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17. Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats
ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= 6) that received 25 mg/kg of encapsulated usnic acid by
An. Acad. Bras. Ciênc.. Publicado em: 2017-06
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18. Efeitos de um dispositivo intravítreo de dexametasona na inflamação ocular após facoemulsificação em cães
RESUMO: O estudo examinou a eficácia de um dispositivo intravítreo de liberação de dexametasona para o controle da inflamação ocular em cães, após facoemulsificação. Um dispositivo de copolímero poli (ácido lático-co-glicólico) foi implantado via pars plana na câmera vítrea, imediatamente antes da facoemulsificação (grupo dispositivo [GD],
Cienc. Rural. Publicado em: 03/10/2016
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19. ENCAPSULATION OF EXTRACT FROM WINERY INDUSTRY RESIDUE USING THE SUPERCRITICAL ANTI-SOLVENT TECHNIQUE
Abstract Grape pomace (seed, skin and stem) is a winery byproduct with high levels of biologically active compounds, such as antioxidants and antimicrobials, that could be converted into high added-value products. Since these components are easily degraded by oxygen, light and high temperature exposure, stabilization is important, for instance, by a microenc
Braz. J. Chem. Eng.. Publicado em: 2016-09
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20. Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin
Abstract Oxaliplatin was inserted into polymeric matrices aiming to study the interaction of this drug with these polymers and its capability to diffuse to the environment. Tested polymers were: (1) polyethylene glycol (PEG), (2) poly(lactic-co-glycolic acid) (PLGA), and (3) a copolymer of them (PLGA-PEG). The latter two were synthesized by us using polycond
Polímeros. Publicado em: 07/06/2016
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21. Static compression regulates OPG expression in periodontal ligament cells via the CAMK II pathway
ABSTRACT Objective This study aimed to investigate the potential role of CAMK II pathway in the compression-regulated OPG expression in periodontal ligament cells (PDLCs). Material and Methods The PDL tissue model was developed by 3-D culturing human PDLCs in a thin sheet of poly lactic-co-glycolic acid (PLGA) scaffolds, which was subjected to static com
J. Appl. Oral Sci.. Publicado em: 2015-12
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22. Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres
Poly(glycolide-co-lactide) (PLGA) nanospheres containing magnetic materials have been extensively studied because of its biomedical applications. Therefore, it is very important to know thermal properties of these materials in addition to other physical properties. Thermal degradation activation energy (Eα) of PLGA nanospheres with maghemite entrapment (PLG
Mat. Res.. Publicado em: 24/11/2015
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23. Incorporação do hormônio do crescimento humano recombinante (rhGH) em matriz de polímero biodegradável
Resumo Objetivo Incorporar o hormônio de crescimento recombinante humano em um polímero biodegradável (PLGA).
Material e método As matrizes foram confeccionadas através da técnica de evaporação de solventes. Foi feita uma mistura do polímero (poli ácido glicólico lático) e do horm
Rev. odontol. UNESP. Publicado em: 2015-08
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24. Desenvolvimento da metodologia para síntese do poli(ácido lático-co-ácido glicólico) para utilização na produção de fontes radioativas
Resumo A Organização Mundial da Saúde (OMS) relata o câncer como uma das principais causas de morte no mundo. Uma modalidade de tratamento que vem sendo bastante utilizada no tratamento do câncer de próstata é a braquiterapia, que consiste na introdução de sementes com material radioativo no interior do orgão. Sementes de Iodo-125
Polímeros. Publicado em: 2015-06