Peg Phosphate
Mostrando 1-12 de 43 artigos, teses e dissertações.
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1. Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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2. Purification of C-phycocyanin from Spirulina platensis in aqueous two-phase systems using an experimental design
C-phycocyanin from Spirulina platensis was purified in aqueous two-phase systems (ATPS) of polyethylene glycol (PEG)/potassium phosphate, varying the molar mass of the PEG. Results using a full factorial design showed that an increase in the concentration of salt and decrease in the concentration of PEG caused an increment in the purification factor for all
Braz. arch. biol. technol.. Publicado em: 2015-02
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3. Extraction of lipase from Burkholderia cepacia by PEG/Phosphate ATPS and its biochemical characterization
This work aimed to study the partitioning of a lipase produced by Burkholderia cepacia in PEG/Phosphate aqueous two phase system (ATPS) and its characterization. Lipase was produced by B. cepacia strains in a fermenter. Enzyme partitioning occurred at pH 6.0 and 8.0, using PEG 1500 and 6000 on two tie lines. Metal ions, pH and temperature effects on enzyme a
Brazilian Archives of Biology and Technology. Publicado em: 2012-02
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4. Partition of proteases from Lentinus citrinus DPUA 1535 by the Peg/Phosphate Aqueous Two-Phase System
A full two-level factorial design was employed to study the influence of PEG molar mass (MM PEG), PEG concentration (C PEG) and phosphate concentration (C PHOSPH) on proteases partition by Lentinus citrinus DPUA 1535 in a PEG/phosphate aqueous two-phase system (ATPS). For all ATPS studied, proteases partitioned for the top phase and the best proteases extrac
Quím. Nova. Publicado em: 2012
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5. The effect of pH on bromelain partition from Ananas comosus by PEG4000/phosphate ATPS
In this work, the thermodynamic equilibrium and applying of PEG4000/Phosphate ATPS on the purification of bromelain extracted from pineapple was studied. A rigorous study of the equilibrium curves and tie-line length from PEG4000/phosphate ATPS were done for the pH 6-11 at 25ºC. Results showed that there was augment in the PEG and salt contents with the hig
Brazilian Archives of Biology and Technology. Publicado em: 2011-02
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6. Partição da lectina de Canavalia grandiflora Benth em sistemas de duas fases aquosas e aplicação em processo cicatricial / Partition of the lectin from Canavalia grandiflora Benth in aqueous two-phase systems and application healing
The purification process is a limiting step of biomolecules for use in processes in biotechnology, especially lectins, due to the cost of up to 90%, and the large number of steps to obtain the pure molecule, resulting in a low yield. Thus, the aqueous two-phase system (ATPS) was proposed as an alternative for the purification of lectin from Canavalia grandif
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2010
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7. Análise da viabilidade econômica da purificação da bromelina das folhas de curauá em sistema bifásico aquoso PEG/Fosfato / Economic viability of bromelain purification from curaua using an aqueous two phase system PEG/phosphate
O curauá (Ananas Erectifolius L.B. Smith), espécie vegetal de porte herbáceo, é uma monocotiledônea pertencente à família Bromeliaceae, nativa da região norte do Brasil, especialmente da Amazônia, de onde pode ser extraída a bromelina. Essa faz parte de um grupo de enzimas proteolíticas, usadas na indústria alimentícia e como medicamento, pois o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/06/2010
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8. Partition of glucose oxidase from Aspergillus niger in aqueous two-phase systems based on salt and polyethylene glycol
The aim of this work was to study the isolation of glucose oxidase (GOx) from Aspergillus niger in aqueous two phase system consisting of PEG 7500 (150g l-1), potassium phosphate (175 g l-1, K2HPO4 +KH2PO4) and glucose (10 gl-1), the enzyme was partitioned in polymer phase. By sequential extraction GOx (69.2%) was recovered in polymer phase by 11.8 fold puri
Brazilian Archives of Biology and Technology. Publicado em: 2010-10
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9. Production and extraction of clavulanic acid from Streptomyces spp. by extractive fermentation using aqueous two-phase system / Produção e extração de ácido clavulânico de Streptomyces spp. por fermentação extrativa utilizando sistemas de duas fases aquosas
Clavulanic acid (CA) is a potent inhibitor of β-lactamases used in the medical field. Alternative methods, economic and simple purification are of great interest. This PhD project aims to produce and extract clavulanic acid of Streptomyces spp. By extractive fermentation using aqueous two-phase system (ATPS) - Polyethylene glycol (PEG)/phosphate salts.
Publicado em: 2010
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10. Study of pre-formulation, pharmaceutical development and characterization of solid dosage forms of olanzapine / Estudo de pré-formulação, desenvolvimento farmacotécnico e caracterização de formas farmacêuticas sólidas da olanzapina
Among manufacturing processes available, direct compression is indicated for OLZ because this drug is moisture sensitive. Before drug developement, preformulation investigations involving physical and chemical properties of drug and excipient combined and separated must be performed. Thus, drug solubility profile, thermal analysis techniques, mainly DSC and
Publicado em: 2010
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11. Caracterização e purificação da enzima bromelina derivada do curaua (Ananas erectifolius) em sistema bifasico aquoso PEG/fosfato / Purification and characterization of enzyme bromelain from curaua (Ananas erectifoliius) in an aqueous phase system with PEG/phosphate
O curauá (Ananas erectifolius) é uma planta fibrosa proveniente da Amazônia brasileira, pertencente à família Bromeliaceae e ao gênero Ananas. A bromelina é uma protease de origem vegetal, obtida de diversas espécies da família Bromeliaceae. A bromelina tem utilização bastante difundida em processos industriais nas áreas alimentícia e farmacêut
Publicado em: 2009
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12. Study of Fluidized Bed Hot Melt Granulation using solid Dispersion of Indomethacin / Estudo da granulação por solidificação de materiais fundidos em leito fluidizado utilizando dispersão sólida de indometacina
Recently, there is a renewed interest in the fluidized bed hot melt granulation for the preparation of solid dosage forms in the pharmaceutical industry and academy. The several advantages of this technique have attracted may researchers, but the main advantage are undoubtedly the solvent free operation and the short processing times. The aim of this work wa
Publicado em: 2009