Notch Signaling
Mostrando 1-12 de 237 artigos, teses e dissertações.
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1. MicroRNA-124a Protects the Myocardium Against Ischemia Reperfusion Injury Through Regulation of the Notch Signaling Pathway
Abstract Introduction: This study’s objective is to investigate the effect of downregulation of micro ribonucleic acid (miR)-124a on myocardial injury after ischemia reperfusion (I/R) in rats. Methods: Sprague Dawley (SD) rats (n=20) were divided into four groups - sham, I/R, I/R+miR-124a antagomir (I/R+ant-miR-124a), and I/R+ant-normal control (NC). The
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Downregulation of Notch4 - a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma
Resumo Introdução: O carcinoma verrucoso de cavidade oral é uma forma especial de carcinoma de células escamosas bem diferenciada que tem características clínicas, morfológicas e citocinéticas específicas que diferem de outros tipos de cânceres orais. Por essa razão, o diagnóstico requer grande experiência em histopatologia. Portanto, é certam
Braz. j. otorhinolaryngol.. Publicado em: 2019-02
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3. MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts
Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression leve
Braz J Med Biol Res. Publicado em: 18/10/2018
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4. Effect of CRABP2 on the proliferation and odontoblastic differentiation of hDPSCs
Abstract: Cellular retinoic acid-binding protein 2 (CRABP2) has been detected in several organs during embryonic development. Recent studies have demonstrated that CRABP2 plays important roles in the retinoic acid, β-catenin and Notch signaling pathways, as well as in the interaction between epithelial and mesenchymal cells, which are important for human de
Braz. oral res.. Publicado em: 18/12/2017
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5. Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice
Asthma is a chronic allergic disease characterized by airway inflammation, airway hyper-responsiveness (AHR), and mucus hypersecretion. T-lymphocytes are involved in the pathogenesis of asthma, mediating airway inflammatory reactions by secreting cytokines. The phosphoinositide 3-kinase (PI3K) and Notch signaling pathways are associated with T cell signaling
Braz J Med Biol Res. Publicado em: 20/07/2017
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6. Expression analysis of Notch signaling pathway molecules in SHED cultured in keratinocyte growth medium
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM).
Methods: RNA was extracted from SHED harvested on day 1, 3 and 7. RNA was reve
Braz. J. Oral Sci.. Publicado em: 2015-06
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7. Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion
Notch signaling plays a vital role in tumorigenicity and tumor progression by regulating proliferation, invasion, and the tumor microenvironment. Previous research by our group indicated that Notch ligand Delta-like 1 (Dll1) is involved in angiogenesis in melanoma, and we noticed that it took a longer time to trypsinize Dll1-expressing B16 melanoma cells tha
Braz J Med Biol Res. Publicado em: 28/03/2014
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8. Role of Notch signaling in the mammalian heart
Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical in mammalian cardiogenesis, as mutations in this signaling pathway are linked to human congenital heart d
Braz J Med Biol Res. Publicado em: 12/12/2013
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9. Avaliação da expressão de receptores e ligantes Notch nas populações de linfócitos T em desenvolvimento, linfócitos T reguladores naturais e células dendríticas no timo humano / Evaluation of the expression of Notch receptors and ligands in developing lymphocytes, natural regulatory T cells and dendritic cells in human thymus
The thymus is a primary lymphoid organ responsible of maturing T lymphocytes, where specialized structures and cells are observed. The intrathymic signaling during lymphocytes maturation is unclear. Among them, Notch signaling pathway, which comprises in receptors (Notch1-4) and ligands (DLL1, 2 and 3, Jaaged1 and 2), may regulate this process. In this work
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/09/2012
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10. O papel da sinalização Notch na diferenciação do epitélio pulmonar. / The role of Notch signaling in lung epithelial differentiation.
O epitélio pulmonar é formado por uma grande diversidade celular, que incluí: células secretoras, ciliadas, basais e neuroendócrinas (NE). A distribuição balanceada destes tipos celulares é crucial para a função pulmonar e pode ser dramaticamente alterada em doenças como a asma. Neste trabalho, estudamos o papel de Notch no pulmão em desenvolvime
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/01/2012
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11. Estudos estruturais e funcionais das proteínas cinases humanas Nek1 e Nek6 / Structural and functional studies of Nek1 Nek6 protein kinases
NIMA was identified and functionally characterized in Aspergillus nidulans as a critical Ser/Thr kinase for cell cycle progression. The mammalian Neks (NIMA-related kinases) represent an evolutionarily conserved family of 11 serine/threonine kinases that share 40-45% identity with NIMA N-terminal domain. Neks are associated to cell cyclerelated functions and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/03/2011
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12. Importância da Via de Sinalização Notch no Transplante / Importance of the Notch Signaling Pathway in Transplantation
Novas descobertas indicam que Notch e seus ligantes nas celulas apresentadoras de antigeno (APCs) sao importantes mediadores do processo de diferenciacao dos linfocitos T. No transplante, certos subtipos de linfocitos T foram observados como predominantes na rejeicao (Th1/linfocitos T citotoxicos), enquanto outros estao presentes na tolerancia (Th2/ Tregs).
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011