Myeloid Proliferation
Mostrando 1-12 de 209 artigos, teses e dissertações.
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1. Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
RESUMO O envelhecimento saudável está relacionado, pelo menos em parte, com a função adequada do sistema imunológico. Isso porque já foi relatado que, com o envelhecimento, algumas mudanças desse sistema são observadas, como a diminuição da percentagem e do repertório de células T pela involução tímica, acúmulo de células T de memória por i
Einstein (São Paulo). Publicado em: 02/05/2019
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2. SÍNTESES E PROPRIEDADES DE FÁRMACOS INIBIDORES DA TIROSINA QUINASE BCR-ABL, UTILIZADOS NO TRATAMENTO DA LEUCEMIA MIELOIDE CRÔNICA
The chronic myeloid leukemia (CML) is characterized by presence of the Philadelphia chromosome (Ph), originated from the translocation between chromosomes 9 and 22. This chromosome generates an abnormal protein tyrosine kinase which is responsible for tumor cell proliferation. The emergence of tyrosine kinase inhibitors (TKIs) has transformed the treatment o
Quím. Nova. Publicado em: 2017-08
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3. Motivating medical students to learn basic science concepts using chronic myeloid leukemia as an integration theme
Objective: To report on the use of chronic myeloid leukemia as a theme of basic clinical integration for first year medical students to motivate and enable in-depth understanding of the basic sciences of the future physician. Methods: During the past thirteen years we have reviewed and updated the curriculum of the medical school of the Universidade Estadu
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-02
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4. A combination of STI571 and BCR-ABL1 siRNA with overexpressed p15INK4B induced enhanced proliferation inhibition and apoptosis in chronic myeloid leukemia
p15INK4B, a cyclin-dependent kinase inhibitor, has been recognized as a tumor suppressor. Loss of or methylation of the p15INK4B gene in chronic myeloid leukemia (CML) cells enhances myeloid progenitor formation from common myeloid progenitors. Therefore, we examined the effects of overexpressed p15INK4B on proliferation and apoptosis of CML cells. Overexpre
Braz J Med Biol Res. Publicado em: 14/10/2014
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5. Antitumor activity of C-phycocyanin from Arthronema africanum (Cyanophyceae)
Pure C-phycocyanin (C-PC) was isolated from Arthronema africanumto evaluate its potential antitumor effects in vivo and in vitro. Experimental myeloid Graffi tumor in hamsters was used as a model. The cell proliferation assay showed that C-PC treatment, at concentration of 100 µg mL-1 for 24 h, significantly inhibited the growth of Graffi tumor cells (51.4%
Braz. arch. biol. technol.. Publicado em: 29/04/2014
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6. In vitro inhibitory effects of imatinib mesylate on stromal cells and hematopoietic progenitors from bone marrow
Imatinib mesylate (IM) is used to treat chronic myeloid leukemia (CML) because it selectively inhibits tyrosine kinase, which is a hallmark of CML oncogenesis. Recent studies have shown that IM inhibits the growth of several non-malignant hematopoietic and fibroblast cells from bone marrow (BM). The aim of the present study was to evaluate the effects of IM
Braz J Med Biol Res. Publicado em: 25/09/2012
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7. Genes hSecurina e VEGF e células endoteliais circulantes como marcadores de angiogênese em portadores de leucemia mielóide crônica / hSecurin and VEGF genes and circulating endothelial cells as markers of angiogenesis in patients with chronic myeloid leukemia
INTRODUCTION: The impact of the increased expression of vascular endothelial growth factor in the course of chronic myeloid leukemia (CML) is still unknown, but there are reports that those patients have higher vascular density in bone marrow than healthy individuals, particularly in blast crisis. Another factor recently associated with increased angiogenesi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/10/2011
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8. Uncaria tomentosa: POSSÍVEL USO COMO ADJUVANTE NO TRATAMENTO DO CÂNCER CÓLON RETAL / Uncaria tomentosa: POSSIBLE USE AS AN ADJUVANT IN THE TREATMENT OF COLORECTAL CANCER
Reports of the use of cat s claw (Uncaria tomentosa) in patients with cancer, in conjunction with traditional therapies such as chemotherapy and radiotherapy, show decrease in adverse effects to these therapies (such as hair loss, weight loss, nausea, secondary infections, and skin problems). Subsequent research showed that cat s claw may help in the restora
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/09/2011
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9. The role of natural killer cells in chronic myeloid leukemia
Chronic myeloid leukemia is a neoplasia resulting from a translocation between chromosomes 9 and 22 producing the BCR-ABL hybrid known as the Philadelphia chromosome (Ph). In chronic myeloid leukemia a proliferation of malignant myeloid cells occurs in the bone marrow due to excessive tyrosine kinase activity. In order to maintain homeostasis, natural killer
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-06
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10. Caracterização da expressão e função de IRS1 e IRS2 na hematopoese normal, mielodisplásica e leucêmica / IRS1 and IRS2 function and expression in normal, myelodysplastic, and leukemia hematopoiesis
A ocorrência da leucemia aguda resulta de uma combinação de mutações e alterações em funções protéicas que conferem a capacidade de proliferação, defeito na diferenciação e apoptose celular. Síndromes mielodisplásicas (SMD) são desordens hematopoéticas resultantes de alterações na célula pluripotente, caracterizadas por hematopoese inefi
Publicado em: 2011
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11. Histopathological diagnosis of intra- and extrahepatic neonatal cholestasis
The histopathology of the liver is fundamental for the differential diagnosis between intra- and extrahepatic causes of neonatal cholestasis. However, histopathological findings may overlap and there is disagreement among authors concerning those which could discriminate between intra- and extrahepatic cholestasis. Forty-six liver biopsies (35 wedge biopsies
Publicado em: 2010
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12. Caracterização molecular e funcional de ANKHD1 na hematopoese normal e neoplasica / Molecular and functional characterization of ANKHD1 in normal and neoplastic hematopoiesis
The identification and the structural and functional characterization of genes differentially expressed between tumors and normal tissues are fundamental steps towards the understanding of the neoplastic process and the development of new anti-cancer strategies. The Ankyrin Repeat Single KH Domain containing 1 (ANKHD1) was first described in humans in a pros
Publicado em: 2009